Circular RNAs As Genome Destabilisers In Human Disease
Funder
National Health and Medical Research Council
Funding Amount
$2,163,220.00
Summary
Mutation of genes are hallmarks of both cancer and neurological disorders. My research group has identified roles for circular RNAs in both these processes. Now, we must close the loop by investigating the mechanism of these processes. This will inform not only why these genes are commonly mutated, but by exploiting the highly stable circular RNAs they may provide early prognostic/diagnostic biomarkers and even represent novel therapeutic targets for cancer and Huntington’s disease.
Where Gesture Meets Grammar: Crosslinguistic Multimodal Communication. This project aims to investigate both differences and universal tendencies in the interplay of speech and gesture across four languages of importance for Australia. The crucial role of gestures is often overlooked in the analysis of communication. In this project, specialists from linguistics, gesture and cultural studies, psychology and cognitive science collaborate using an innovative approach to generate new knowledge abou ....Where Gesture Meets Grammar: Crosslinguistic Multimodal Communication. This project aims to investigate both differences and universal tendencies in the interplay of speech and gesture across four languages of importance for Australia. The crucial role of gestures is often overlooked in the analysis of communication. In this project, specialists from linguistics, gesture and cultural studies, psychology and cognitive science collaborate using an innovative approach to generate new knowledge about how speech and gesture interact to communicate meaning. The project can provide significant benefits for our understanding of language and cognition, cross-cultural communication in multilingual Australia, and the documentation of endangered languages.Read moreRead less
Macroecology of reptiles and frogs over latitudinal and temporal gradients. This project aims to address major macroecological concepts in reptile and frog communities through time, focusing on environmental and climatic gradients in species diversity and body-size variation. This project expects to generate a unique macroecological dataset by integrating data from Quaternary fossil sites spanning a 3000km latitudinal gradient with current ecological data. Expected outcomes include the first com ....Macroecology of reptiles and frogs over latitudinal and temporal gradients. This project aims to address major macroecological concepts in reptile and frog communities through time, focusing on environmental and climatic gradients in species diversity and body-size variation. This project expects to generate a unique macroecological dataset by integrating data from Quaternary fossil sites spanning a 3000km latitudinal gradient with current ecological data. Expected outcomes include the first comprehensive ecological assessment of Australian reptile and frog communities through Pleistocene climate oscillations, with predictions into the future. This research will benefit Australian society by providing evidence-based knowledge of faunal community composition through time in association with changing climates.Read moreRead less
Mid-Career Industry Fellowships - Grant ID: IM230100544
Funder
Australian Research Council
Funding Amount
$862,952.00
Summary
Unlocking the archive: reuniting Indigenous languages and their communities. Australia is experiencing a crisis in the loss of Indigenous languages. Drawing on both international best practice and local knowledge, this project aims to develop innovative and enduring resources for community-driven language maintenance and revitalisation. By collaborating with and building the capacity of Indigenous language workers and organisations, the following transformative outcomes are anticipated: (1) tool ....Unlocking the archive: reuniting Indigenous languages and their communities. Australia is experiencing a crisis in the loss of Indigenous languages. Drawing on both international best practice and local knowledge, this project aims to develop innovative and enduring resources for community-driven language maintenance and revitalisation. By collaborating with and building the capacity of Indigenous language workers and organisations, the following transformative outcomes are anticipated: (1) tools to unlock linguistic terminology and methods; (2) resources for language revitalisation; (3) an evaluation of existing strategies for language revitalisation; (4) new understanding of Indigenous people's perceptions of language change and how this informs their language goals.Read moreRead less
Improving stream management using ecological modelling and DNA barcodes. Rivers and streams provide invaluable ecosystem services, yet are commonly degraded by human activities: a problem likely to be exacerbated by thermal and flow regimes being altered by climate change. Stream biodiversity is both a value and an indicator of ecological health: effective stream management requires prediction of biodiversity responses to natural environmental and human-impact gradients. By compiling a dataset o ....Improving stream management using ecological modelling and DNA barcodes. Rivers and streams provide invaluable ecosystem services, yet are commonly degraded by human activities: a problem likely to be exacerbated by thermal and flow regimes being altered by climate change. Stream biodiversity is both a value and an indicator of ecological health: effective stream management requires prediction of biodiversity responses to natural environmental and human-impact gradients. By compiling a dataset of macroinvertebrate species using new DNA metabarcoding, modelling their distributions, and ranking biodiversity by reach, we will develop molecular and quantitative spatial tools to provide data-driven, landscape-scale decision support for protecting and restoring streams: an urgent need for stream managers globally.Read moreRead less
Dawn of the age of mammals in Australia: foundations for an island biota. This project aims to fill a profound gap in knowledge about the origins of the modern fauna on the island continent Australia. It will augment Australia’s national natural heritage, enhance international research collaboration, and provide critical baseline data for complementary research in biology, geology, geography and climatology. End users of this project include primary, secondary, tertiary and public education sect ....Dawn of the age of mammals in Australia: foundations for an island biota. This project aims to fill a profound gap in knowledge about the origins of the modern fauna on the island continent Australia. It will augment Australia’s national natural heritage, enhance international research collaboration, and provide critical baseline data for complementary research in biology, geology, geography and climatology. End users of this project include primary, secondary, tertiary and public education sectors and environment and heritage protection agencies.Read moreRead less