Characterisation Of Two Novel Markers Of Osteosarcoma Metastasis As Potential Therapeutic Targets
Funder
National Health and Medical Research Council
Funding Amount
$624,500.00
Summary
Osteosarcoma (OS) is the most common bone tumour in children and adolescents. In spite of aggressive chemotherapy, OS tumours that metastasise to the lungs result in dismal long-term survivals of only 10-20%. For these patients, new treatment options are desperately needed. In this proposal we show compelling data identifying two new markers of OS metastasis. This research aims to validate the suitability of these novel markers as therapeutic targets to prevent OS metastasis.
Whistling While They Work: Enhancing the Theory and Practice of Internal Witness Management in Public Sector Organisations. The protection of whistleblowers and other internal witnesses to corruption, misconduct and maladministration is a great unsolved problem in public sector governance. Involving 11 integrity institutions, this first national study of internal witness management will describe and compare organisational experience under varying public interest disclosure regimes across the Au ....Whistling While They Work: Enhancing the Theory and Practice of Internal Witness Management in Public Sector Organisations. The protection of whistleblowers and other internal witnesses to corruption, misconduct and maladministration is a great unsolved problem in public sector governance. Involving 11 integrity institutions, this first national study of internal witness management will describe and compare organisational experience under varying public interest disclosure regimes across the Australian public sector. By identifying and promoting current best practice in workplace responses to public interest whistleblowing, the project will use the experience and perceptions of internal witnesses and first- and second-level managers to identify more routine strategies for preventing, reducing and addressing reprisals and other whistleblowing-related conflicts.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE150100652
Funder
Australian Research Council
Funding Amount
$345,000.00
Summary
Regulation of organ size and stem cell hierarchy in the developing kidney. Transient stem/progenitor cell populations play essential roles in establishing organ systems. The balance between self-renewal and differentiation in the nephron progenitor population plays a major, but poorly understood, role in regulating kidney development. Factors produced by undifferentiated progenitors promote organ expansion, whereas differentiation of these cells builds functional capacity. What is not clear is h ....Regulation of organ size and stem cell hierarchy in the developing kidney. Transient stem/progenitor cell populations play essential roles in establishing organ systems. The balance between self-renewal and differentiation in the nephron progenitor population plays a major, but poorly understood, role in regulating kidney development. Factors produced by undifferentiated progenitors promote organ expansion, whereas differentiation of these cells builds functional capacity. What is not clear is how the balance between self-renewal and differentiation is regulated in these cells, nor how the control of this fate decision impacts on optimal organ development. This project aims to dissect the molecular identity, regulation, and influence of this stem cell population on kidney development.Read moreRead less
Genetic variation of single cell transcriptional heterogeneity in HiPSCs. This project aims to investigate whether induced pluripotent stem cells (iPSC) can be used to study the functions of genetic variants associated with human phenotypes and cell fate decisions. The project will utilise technology to produce single cell RNA sequence data for 100,000s of cells. By sequencing individual cells, the genetic control of cellular heterogeneity both within and between cells can be identified, and in ....Genetic variation of single cell transcriptional heterogeneity in HiPSCs. This project aims to investigate whether induced pluripotent stem cells (iPSC) can be used to study the functions of genetic variants associated with human phenotypes and cell fate decisions. The project will utilise technology to produce single cell RNA sequence data for 100,000s of cells. By sequencing individual cells, the genetic control of cellular heterogeneity both within and between cells can be identified, and in doing so, will provide significant benefit by revealing the potential for iPSC to be used for functional translation of human genomics.Read moreRead less
Preventing Early Internalising Problems In The Preschool Setting: Randomised Controlled Trial
Funder
National Health and Medical Research Council
Funding Amount
$893,870.00
Summary
Internalising mental health problems reflect inner emotional distress and encompass all symptoms of anxiety and depression. Affecting 1 in 7 Australian school-age children, many internalising problems persist into adulthood, impacting on personal wellbeing, family relations and workforce capabilities. This randomised prevention trial in the preschool-setting, screens for children at-risk and tests if a parenting program can reduce internalising problems across the population by school-entry.
Genomics of temperature response in plants. Climate change is predicted to have negative impacts on Australian agriculture. This project will use genomic tools to uncover biological mechanisms for plant response to temperature that will help design crop varieties that are more tolerant to higher temperatures.
The role of X-chromosome inactivation in quantitative trait variation. This project aims to develop methods and software that can be applied to genetic and genomic studies in animal breeding, wildlife protection, and humans. X-chromosome inactivation (XCI) is an important biological phenomenon but its effect on quantitative trait variation remains largely unknown. This project aims to develop novel statistical methods to estimate the X-linked genetic variance and the proportion that escapes XCI, ....The role of X-chromosome inactivation in quantitative trait variation. This project aims to develop methods and software that can be applied to genetic and genomic studies in animal breeding, wildlife protection, and humans. X-chromosome inactivation (XCI) is an important biological phenomenon but its effect on quantitative trait variation remains largely unknown. This project aims to develop novel statistical methods to estimate the X-linked genetic variance and the proportion that escapes XCI, and identify trait-associated genetic variants affected and not affected by XCI. The methods would then be applied to large datasets from genome-wide association studies for a large number of traits. Project outcomes may enable us to better understand the role of XCI in quantitative trait variation and gene expression in humans and animals.Read moreRead less
Functional analysis of alternative splicing in plants. Higher temperatures affect flowering and seed set in plants. How plants sense and respond to temperature is currently unclear. Here we study alternative splicing, one of the processes affected by temperature. These studies will advance our knowledge and help develop crops that can withstand negative effects of climate change.
Understanding and Managing the Occupational Health Impacts on Investigators of Internet Child Exploitation. Through developing best practice models for managing vicarious trauma in investigators of Internet child exploitation, the project will result in enhanced job satisfaction and less burnout of workers, and reduced health costs for policing organisations. Thus the project addresses a serious occupational health issue and contributes to the goal of promoting and maintaining good health. Furth ....Understanding and Managing the Occupational Health Impacts on Investigators of Internet Child Exploitation. Through developing best practice models for managing vicarious trauma in investigators of Internet child exploitation, the project will result in enhanced job satisfaction and less burnout of workers, and reduced health costs for policing organisations. Thus the project addresses a serious occupational health issue and contributes to the goal of promoting and maintaining good health. Further, by better managing the occupational health of investigators, the project will enhance the capacity of police organisations to deliver on their mission of investigating and preventing Internet child exploitation. This in turn contributes to the reduced consumption of Internet child exploitation and the associated traumatisation of abused victims. Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE110100068
Funder
Australian Research Council
Funding Amount
$240,000.00
Summary
Mass spectrometry platform for high throughput genotyping, epigenetic analysis and validation of genome wide sequencing studies. This facility will provide a platform for Australian researchers to quantitatively measure genetic information in a rapid, accurate and cost-efficient manner. This technology will enhance Australia's ability to perform basic research into the genetic and epigenetic mechanisms of cellular function.