3D analysis of facial features for proof of identity across Australia's ethnically diverse population. The forensic sciences concerned with establishing Human identity play a vital role in safeguarding Australia. Certainty in Human identification is required by police and intelligence agencies because knowing the identity of perpetrators (or potential perpetrators) of crime allows effective preventative intervention. This is particularly important during surveillance operations and in the contex ....3D analysis of facial features for proof of identity across Australia's ethnically diverse population. The forensic sciences concerned with establishing Human identity play a vital role in safeguarding Australia. Certainty in Human identification is required by police and intelligence agencies because knowing the identity of perpetrators (or potential perpetrators) of crime allows effective preventative intervention. This is particularly important during surveillance operations and in the context of border protection. When crime has already been committed, the identification of victims and perpetrators is important for the exoneration of the innocent and successful prosecution of the guilty. The full utilisation of 3D morphometric analysis of faces will provide criteria robust enough for legal proof of identity. Read moreRead less
Understanding the nature and characteristics of youth violence in Australia. This study addresses the important problem of violence in Australian youth and the need for early intervention/prevention to limit further reoccurrences and escalation of violence across the life span and its associated economic and health costs. For the first time we will have specific access to Australian data on violent offending patterns and risk in adolescents for use in service planning rather than attempting to a ....Understanding the nature and characteristics of youth violence in Australia. This study addresses the important problem of violence in Australian youth and the need for early intervention/prevention to limit further reoccurrences and escalation of violence across the life span and its associated economic and health costs. For the first time we will have specific access to Australian data on violent offending patterns and risk in adolescents for use in service planning rather than attempting to apply findings from North America and Europe to our unique population. Work in this field will help improve the characterisation and identification of at-risk individuals and should ultimately improve our ability to direct treatment interventions to the most needy and most high risk groups.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE120102575
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
Exploring new territory in climatic adaptation research: integrating molecular genetics with species' thermal tolerance limits. Predicting species' responses to environmental change requires mechanistic links between whole-organism physiological stress responses and underlying cellular mechanics. This project integrates cutting-edge methods in molecular and evolutionary genetics to probe species' responses to environmental change in the context of a warming environment.
Metabolic control of gene expression networks and microbiome interactions. The proposal aims to advance our understanding of how metabolism (and resulting metabolites) regulate the expression of genes, and investigate how these processes dictate the interaction of microbiota with the immune system. The project is expected to generate transformative knowledge of gene regulation, a fundamental process for cellular function, and decipher how the microbiome yeast Candida albicans interacts with immu ....Metabolic control of gene expression networks and microbiome interactions. The proposal aims to advance our understanding of how metabolism (and resulting metabolites) regulate the expression of genes, and investigate how these processes dictate the interaction of microbiota with the immune system. The project is expected to generate transformative knowledge of gene regulation, a fundamental process for cellular function, and decipher how the microbiome yeast Candida albicans interacts with immune cells and bacteria. By utilising a powerful combination of molecular and systems biology with molecular genetics and imaging, the project outcomes should foster interdisciplinary collaborations and build capacity for fundamental and applied research to benefit academia and industry, locally and globally.Read moreRead less
Whistling While They Work: Enhancing the Theory and Practice of Internal Witness Management in Public Sector Organisations. The protection of whistleblowers and other internal witnesses to corruption, misconduct and maladministration is a great unsolved problem in public sector governance. Involving 11 integrity institutions, this first national study of internal witness management will describe and compare organisational experience under varying public interest disclosure regimes across the Au ....Whistling While They Work: Enhancing the Theory and Practice of Internal Witness Management in Public Sector Organisations. The protection of whistleblowers and other internal witnesses to corruption, misconduct and maladministration is a great unsolved problem in public sector governance. Involving 11 integrity institutions, this first national study of internal witness management will describe and compare organisational experience under varying public interest disclosure regimes across the Australian public sector. By identifying and promoting current best practice in workplace responses to public interest whistleblowing, the project will use the experience and perceptions of internal witnesses and first- and second-level managers to identify more routine strategies for preventing, reducing and addressing reprisals and other whistleblowing-related conflicts.Read moreRead less
Closed Circuit Television Surveillance, Security Networks and Australian Public Space. This project will make a significant contribution to our understandings of how visual surveillance systems impact upon the way public spaces are experienced and utilised. By examining the social impacts of surveillance this study will facilitate the development of security measures that facilitate greater inclusiveness and community cooperation. It will also assist the development of security measures cognizan ....Closed Circuit Television Surveillance, Security Networks and Australian Public Space. This project will make a significant contribution to our understandings of how visual surveillance systems impact upon the way public spaces are experienced and utilised. By examining the social impacts of surveillance this study will facilitate the development of security measures that facilitate greater inclusiveness and community cooperation. It will also assist the development of security measures cognizant of local variation and potential social consequences. Read moreRead less
International student safety from crime. International education currently generates $15.5 billion per annum in exports and involves 520,000 students in Australia. Safety from crime is a fundamental requirement of international students and source governments are insisting Australia needs to improve student safety. These demands must be met if Australia is to sustain its level of involvement in the industry. The project will assist this effort by helping develop solutions to student crime proble ....International student safety from crime. International education currently generates $15.5 billion per annum in exports and involves 520,000 students in Australia. Safety from crime is a fundamental requirement of international students and source governments are insisting Australia needs to improve student safety. These demands must be met if Australia is to sustain its level of involvement in the industry. The project will assist this effort by helping develop solutions to student crime problems that are tailored to Australia's unique circumstances. The project will help enrich Australia's international reputation and improve the safety of international students and Australian communities.Read moreRead less
The transcriptome dynamics that refine eukaryotic gene expression. This project aims to understand the fundamental mechanisms of gene expression control, by exploring how cells respond to acute perturbation with changes to RNA expression and processing. Unlike the static information encoded within the genome, the information encoded in its intermediary RNA, is transient, plastic and responsive to environmental and developmental cues. This project will use new technologies encompassing RNA-bioche ....The transcriptome dynamics that refine eukaryotic gene expression. This project aims to understand the fundamental mechanisms of gene expression control, by exploring how cells respond to acute perturbation with changes to RNA expression and processing. Unlike the static information encoded within the genome, the information encoded in its intermediary RNA, is transient, plastic and responsive to environmental and developmental cues. This project will use new technologies encompassing RNA-biochemistry, Next Generation Sequencing, and bioinformatics to answer long-standing questions in RNA processing. The project expects to significantly enhance our understanding of the mechanisms underpinning gene-expression control, benefitting Australia by positioning it as a world leader in the field of RNA Biology.Read moreRead less
Uncovering microRNA decay regulation in mammalian cells. MicroRNAs (miRNAs) constitute a novel mechanism used by cells to regulate gene expression, however, very little is known about the mechanisms affecting miRNA accumulation. Characterisation of the kinetics of miRNA turnover is of paramount importance to establish the reliability of miRNAs as novel biomarkers. This project aims to characterise miRNA stability in mammalian cells, investigate mechanisms of turnover and establish their importan ....Uncovering microRNA decay regulation in mammalian cells. MicroRNAs (miRNAs) constitute a novel mechanism used by cells to regulate gene expression, however, very little is known about the mechanisms affecting miRNA accumulation. Characterisation of the kinetics of miRNA turnover is of paramount importance to establish the reliability of miRNAs as novel biomarkers. This project aims to characterise miRNA stability in mammalian cells, investigate mechanisms of turnover and establish their importance on the regulatory function of miRNAs. Such information is critical in the future development of targeted therapeutics.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE150100652
Funder
Australian Research Council
Funding Amount
$345,000.00
Summary
Regulation of organ size and stem cell hierarchy in the developing kidney. Transient stem/progenitor cell populations play essential roles in establishing organ systems. The balance between self-renewal and differentiation in the nephron progenitor population plays a major, but poorly understood, role in regulating kidney development. Factors produced by undifferentiated progenitors promote organ expansion, whereas differentiation of these cells builds functional capacity. What is not clear is h ....Regulation of organ size and stem cell hierarchy in the developing kidney. Transient stem/progenitor cell populations play essential roles in establishing organ systems. The balance between self-renewal and differentiation in the nephron progenitor population plays a major, but poorly understood, role in regulating kidney development. Factors produced by undifferentiated progenitors promote organ expansion, whereas differentiation of these cells builds functional capacity. What is not clear is how the balance between self-renewal and differentiation is regulated in these cells, nor how the control of this fate decision impacts on optimal organ development. This project aims to dissect the molecular identity, regulation, and influence of this stem cell population on kidney development.Read moreRead less