3D analysis of facial features for proof of identity across Australia's ethnically diverse population. The forensic sciences concerned with establishing Human identity play a vital role in safeguarding Australia. Certainty in Human identification is required by police and intelligence agencies because knowing the identity of perpetrators (or potential perpetrators) of crime allows effective preventative intervention. This is particularly important during surveillance operations and in the contex ....3D analysis of facial features for proof of identity across Australia's ethnically diverse population. The forensic sciences concerned with establishing Human identity play a vital role in safeguarding Australia. Certainty in Human identification is required by police and intelligence agencies because knowing the identity of perpetrators (or potential perpetrators) of crime allows effective preventative intervention. This is particularly important during surveillance operations and in the context of border protection. When crime has already been committed, the identification of victims and perpetrators is important for the exoneration of the innocent and successful prosecution of the guilty. The full utilisation of 3D morphometric analysis of faces will provide criteria robust enough for legal proof of identity. Read moreRead less
Understanding the nature and characteristics of youth violence in Australia. This study addresses the important problem of violence in Australian youth and the need for early intervention/prevention to limit further reoccurrences and escalation of violence across the life span and its associated economic and health costs. For the first time we will have specific access to Australian data on violent offending patterns and risk in adolescents for use in service planning rather than attempting to a ....Understanding the nature and characteristics of youth violence in Australia. This study addresses the important problem of violence in Australian youth and the need for early intervention/prevention to limit further reoccurrences and escalation of violence across the life span and its associated economic and health costs. For the first time we will have specific access to Australian data on violent offending patterns and risk in adolescents for use in service planning rather than attempting to apply findings from North America and Europe to our unique population. Work in this field will help improve the characterisation and identification of at-risk individuals and should ultimately improve our ability to direct treatment interventions to the most needy and most high risk groups.Read moreRead less
Closed Circuit Television Surveillance, Security Networks and Australian Public Space. This project will make a significant contribution to our understandings of how visual surveillance systems impact upon the way public spaces are experienced and utilised. By examining the social impacts of surveillance this study will facilitate the development of security measures that facilitate greater inclusiveness and community cooperation. It will also assist the development of security measures cognizan ....Closed Circuit Television Surveillance, Security Networks and Australian Public Space. This project will make a significant contribution to our understandings of how visual surveillance systems impact upon the way public spaces are experienced and utilised. By examining the social impacts of surveillance this study will facilitate the development of security measures that facilitate greater inclusiveness and community cooperation. It will also assist the development of security measures cognizant of local variation and potential social consequences. Read moreRead less
International student safety from crime. International education currently generates $15.5 billion per annum in exports and involves 520,000 students in Australia. Safety from crime is a fundamental requirement of international students and source governments are insisting Australia needs to improve student safety. These demands must be met if Australia is to sustain its level of involvement in the industry. The project will assist this effort by helping develop solutions to student crime proble ....International student safety from crime. International education currently generates $15.5 billion per annum in exports and involves 520,000 students in Australia. Safety from crime is a fundamental requirement of international students and source governments are insisting Australia needs to improve student safety. These demands must be met if Australia is to sustain its level of involvement in the industry. The project will assist this effort by helping develop solutions to student crime problems that are tailored to Australia's unique circumstances. The project will help enrich Australia's international reputation and improve the safety of international students and Australian communities.Read moreRead less
Investigating non-canonical RNA processing in developing spermatids. RNA combines the information content of DNA and the physical properties of proteins. These features mean it's emerging as a major player for new knowledge; for answers to fundamental questions in biology, and for applications in biotechnology. This project aims to understand how non-canonical RNA processing events control gene expression. How mRNA is processed post-transcriptionally for selective storage, translation, stabilisa ....Investigating non-canonical RNA processing in developing spermatids. RNA combines the information content of DNA and the physical properties of proteins. These features mean it's emerging as a major player for new knowledge; for answers to fundamental questions in biology, and for applications in biotechnology. This project aims to understand how non-canonical RNA processing events control gene expression. How mRNA is processed post-transcriptionally for selective storage, translation, stabilisation or decay to control development. RNA-driven processes program morphogenesis and differentiation of spermatids, but via mechanisms only poorly understood. Uncovering the function of extensive cytoplasmic polyadenylation, which is essential for murine fertility, may fuel the next wave of RNA biotech applications. Read moreRead less
Computer-assisted 3D morphometrics for human identification. This project anticipates the rapid adoption by security services of comparative 3-D facial morphometrics for the identification of "persons of interest" and the concomitant creation of large databases of such characteristics. Anatomical knowledge will be used to refine new Japanese software which semi-automatically matches 3D facial landmarks and morphology between suspect and database and to validate its use in Australia. We build on ....Computer-assisted 3D morphometrics for human identification. This project anticipates the rapid adoption by security services of comparative 3-D facial morphometrics for the identification of "persons of interest" and the concomitant creation of large databases of such characteristics. Anatomical knowledge will be used to refine new Japanese software which semi-automatically matches 3D facial landmarks and morphology between suspect and database and to validate its use in Australia. We build on current collaborative research by the applicants in Australia and Japan with funding provided by both governments. Our research has validated comparative facial morphometrics for suspect identification and underpinned the use of facial scanning by police throughout Japan.Read moreRead less
Establishment of Identity from Quantitative Analysis of Facial Characteristics. This project will provide the Criminal Justice systems in Australia and Japan with more rigorous methods of identifying people from eye-witness and surveillance video reports. It builds on research previously undertaken into analysis of facial morphology, and provides an innovative approach to identification through the use of three dimensional modelling and high speed computer graphics augmented by Fourier analysis ....Establishment of Identity from Quantitative Analysis of Facial Characteristics. This project will provide the Criminal Justice systems in Australia and Japan with more rigorous methods of identifying people from eye-witness and surveillance video reports. It builds on research previously undertaken into analysis of facial morphology, and provides an innovative approach to identification through the use of three dimensional modelling and high speed computer graphics augmented by Fourier analysis of shape parameters. The project is part of a formal collaboration with the National Research Institute of Police Science in Tokyo, providing an ethnically diverse data set of three dimensional graphical and mathematical models.Read moreRead less
Understanding co-activator function in transcriptional regulation. A change in gene expression underpins all cell fate decisions yet there is scant knowledge about how transcription factors (TF), the master regulators of transcription, specifically interact with some, but not all, transcription cofactors to nuance gene expression. Aims: Using innovative molecular technologies we will identify and characterise the shared and unique relationships between TF and cofactors. Significance: This study ....Understanding co-activator function in transcriptional regulation. A change in gene expression underpins all cell fate decisions yet there is scant knowledge about how transcription factors (TF), the master regulators of transcription, specifically interact with some, but not all, transcription cofactors to nuance gene expression. Aims: Using innovative molecular technologies we will identify and characterise the shared and unique relationships between TF and cofactors. Significance: This study is important to every biological process in plants and animals driven by a change in gene expression. Expected Outcomes: This study will increase our biological knowledge in transcription control. Benefit: The knowledge gained has future applications in genomics and broad implications for biotechnology and industry.Read moreRead less
Can we exploit mRNA modifications to control protein expression? Genes are encoded by DNA but are transcribed into a message called RNA before they can be translated into protein. RNA can be chemically modified at a gene-specific level, and this modification has been central to the success of RNA vaccines against COVID-19. Despite the importance of these modifications in cellular life and in biotechnology, the role of the most abundant RNA modifications is unclear. This project will investigate ....Can we exploit mRNA modifications to control protein expression? Genes are encoded by DNA but are transcribed into a message called RNA before they can be translated into protein. RNA can be chemically modified at a gene-specific level, and this modification has been central to the success of RNA vaccines against COVID-19. Despite the importance of these modifications in cellular life and in biotechnology, the role of the most abundant RNA modifications is unclear. This project will investigate how we can exploit RNA modifications to modulate protein expression in a tractable single-celled organism with a small genome, Plasmodium. This information is important because understanding gene regulation is fundamental to all life, and the role of RNA modifications is emerging as integral to biotechnology.Read moreRead less
Genetic variation of single cell transcriptional heterogeneity in HiPSCs. This project aims to investigate whether induced pluripotent stem cells (iPSC) can be used to study the functions of genetic variants associated with human phenotypes and cell fate decisions. The project will utilise technology to produce single cell RNA sequence data for 100,000s of cells. By sequencing individual cells, the genetic control of cellular heterogeneity both within and between cells can be identified, and in ....Genetic variation of single cell transcriptional heterogeneity in HiPSCs. This project aims to investigate whether induced pluripotent stem cells (iPSC) can be used to study the functions of genetic variants associated with human phenotypes and cell fate decisions. The project will utilise technology to produce single cell RNA sequence data for 100,000s of cells. By sequencing individual cells, the genetic control of cellular heterogeneity both within and between cells can be identified, and in doing so, will provide significant benefit by revealing the potential for iPSC to be used for functional translation of human genomics.Read moreRead less