Circular RNAs As Genome Destabilisers In Human Disease
Funder
National Health and Medical Research Council
Funding Amount
$2,163,220.00
Summary
Mutation of genes are hallmarks of both cancer and neurological disorders. My research group has identified roles for circular RNAs in both these processes. Now, we must close the loop by investigating the mechanism of these processes. This will inform not only why these genes are commonly mutated, but by exploiting the highly stable circular RNAs they may provide early prognostic/diagnostic biomarkers and even represent novel therapeutic targets for cancer and Huntington’s disease.
Reducing Colorectal Cancer Burden In Young Adults: Precision Prevention And Early Detection
Funder
National Health and Medical Research Council
Funding Amount
$1,449,800.00
Summary
Bowel cancer rate in young adults before age 50 is increasing worldwide including Australia. Since it is impossible to screen everyone, it is critical to identify who is likely to develop the disease, to optimise screening. Using the world's largest resource for young-onset bowel cancer, I will conduct studies to generate high-quality evidence to inform how to best prevent bowel cancer in young adults and translate into the policy and practice, to reduce colorectal cancer burden in young adults.
Discovery Early Career Researcher Award - Grant ID: DE230100197
Funder
Australian Research Council
Funding Amount
$438,000.00
Summary
In one zeptosecond: quantifying energy dissipation in heavy element fusion. This project aims to understand the process of energy dissipation in superheavy element fusion reactions. Using state-of-the art facilities unique to Australia, the first detailed measurements of the crucial early stages of these reactions will be made. This is expected to generate significant fundamental knowledge on why some superheavy element fusion reactions succeed, and why others fail. The outcomes are expected to ....In one zeptosecond: quantifying energy dissipation in heavy element fusion. This project aims to understand the process of energy dissipation in superheavy element fusion reactions. Using state-of-the art facilities unique to Australia, the first detailed measurements of the crucial early stages of these reactions will be made. This is expected to generate significant fundamental knowledge on why some superheavy element fusion reactions succeed, and why others fail. The outcomes are expected to significantly advance the fundamental understanding of nuclear reactions, and provide key guidance to international opportunities to create new superheavy elements and isotopes. Expected benefits include improving cancer treatments, understanding element abundance in the universe and improved safety in nuclear technologies.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE210100755
Funder
Australian Research Council
Funding Amount
$462,948.00
Summary
Developing phytosystems for the biofiltration of air pollutants . This project aims to develop, evaluate and apply a range of biotechnology driven solutions for the use of phytosystem biofilters designed for air purification. The findings of the project will demonstrate the fundamental mechanisms behind botanical air pollutant biofiltration, apply systematic technological development against a range of air pollutants, and provide strategies to deploy the technology. With a transdisciplinary appr ....Developing phytosystems for the biofiltration of air pollutants . This project aims to develop, evaluate and apply a range of biotechnology driven solutions for the use of phytosystem biofilters designed for air purification. The findings of the project will demonstrate the fundamental mechanisms behind botanical air pollutant biofiltration, apply systematic technological development against a range of air pollutants, and provide strategies to deploy the technology. With a transdisciplinary approach utilising techniques new to this discipline, the project will substantially advance the fundamental science underlying this novel and highly valuable area of air-bioremediation technology, and will create a much stronger economic driver for this Australia-led innovation.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE240101090
Funder
Australian Research Council
Funding Amount
$433,217.00
Summary
In-depth Investigation of Lithium Dendrite Formation Processes. Battery failure is mainly derived from uncontrollable lithium dendrite formation. This project aims to investigate fundamental lithium dendrite formation mechanism by utilizing a novel in-situ transmission electron microscopy cell. This project expects to build a new set up which is capable of simultaneous in-situ electrical and nanomechanical measurements of lithium dendrite growth. This project aims to reveal how lithium dendrite ....In-depth Investigation of Lithium Dendrite Formation Processes. Battery failure is mainly derived from uncontrollable lithium dendrite formation. This project aims to investigate fundamental lithium dendrite formation mechanism by utilizing a novel in-situ transmission electron microscopy cell. This project expects to build a new set up which is capable of simultaneous in-situ electrical and nanomechanical measurements of lithium dendrite growth. This project aims to reveal how lithium dendrite growth is affected by different surface modifications on the commercial graphite electrodes. The success of the project will lead to a fundamental understanding of the lithium dendrite formation mechanism, enabling the construction of significantly safer batteries.Read moreRead less
Real-time imaging of crystal strengthening mechanisms in metals. The strength limit of a metal is marked by rapid motion of crystalline defects. The associated speeds can locally approach that of sound. To probe the associated mechanisms clearly requires both spatial and temporal resolution. We propose to create a new bulk x-ray technique with an unprecedented combination of temporal and spatial resolution. We plan to exploit the technique to mediate a step change in modelling strength based on ....Real-time imaging of crystal strengthening mechanisms in metals. The strength limit of a metal is marked by rapid motion of crystalline defects. The associated speeds can locally approach that of sound. To probe the associated mechanisms clearly requires both spatial and temporal resolution. We propose to create a new bulk x-ray technique with an unprecedented combination of temporal and spatial resolution. We plan to exploit the technique to mediate a step change in modelling strength based on twinning. The formation of crystalline twins is known to dictate the strength of the light metal magnesium. A fuller understanding of the effect of twinning on strength in this metal will provide much needed confidence to implement it more widely in energy saving applications.Read moreRead less
Improving thermal environment of housing for older Australians. This project aims to develop strategies to improve the thermal environment of housing for older Australians based on systematic investigations of the links between weather, thermal comfort, energy use, and well-being. The project will produce evidence-based guidelines and a framework about planning/design issues and operational/behavioural aspects to support older people living independently. Improved thermal conditions will lead to ....Improving thermal environment of housing for older Australians. This project aims to develop strategies to improve the thermal environment of housing for older Australians based on systematic investigations of the links between weather, thermal comfort, energy use, and well-being. The project will produce evidence-based guidelines and a framework about planning/design issues and operational/behavioural aspects to support older people living independently. Improved thermal conditions will lead to better quality of life, reduce the need for institutional care and reduce public health costs. They will also provide environmental benefits through reduced energy use and carbon emissions.Read moreRead less