Developing Interpretable Machine Learning Models For Clinical Imaging And Single-cell Genomics
Funder
National Health and Medical Research Council
Funding Amount
$1,312,250.00
Summary
Machine learning methods will be vital to make best use of the deluge of data generated by high-throughput technologies in biomedical science. To get the most out of these models, however, we need to be able to unpack the 'black box'. I will use curated clinical and public research data to benchmark and develop interpretable deep learning models and software tools. These models will be used for breast cancer screening programs and for analysis of complex, large-scale single-cell genomics data.
Melanoma Mutation Profiling For Personalised Treatment
Funder
National Health and Medical Research Council
Funding Amount
$571,191.00
Summary
Melanoma is an aggressive skin cancer, and the leading cause of skin cancer related deaths. Disease spread is difficult to detect and extremely difficult to cure. This bleak clinical outcome is changing with the development of personalised therapies which include small molecule inhibitors to treat metastatic melanoma. Here we seek to identify the spectrum of mutations in patient tumours and circulating tumour cells for advanced personalised treatment.
Vibration Isolation Technology and Instrumentaion for Geophysical Surveys. Many geophysical exploration instruments are limited in sensitivity by vibration induced noise. New techniques of vibration isolation have been shown to eliminate vibration induced noise in a vibrating wire magnetic gradiometer. This project will create fully integrated sensor ?isolation packages for airborne and underwater applications, both for gradiometers and for ground penetrating radars. The project will signific ....Vibration Isolation Technology and Instrumentaion for Geophysical Surveys. Many geophysical exploration instruments are limited in sensitivity by vibration induced noise. New techniques of vibration isolation have been shown to eliminate vibration induced noise in a vibrating wire magnetic gradiometer. This project will create fully integrated sensor ?isolation packages for airborne and underwater applications, both for gradiometers and for ground penetrating radars. The project will significantly benefit the mineral exploration industry as well as underwater detection of cables and ship wrecks.Read moreRead less
Better Planning for and Managing Asymmetric Threats to Australia's Security: Applying the Field Anomaly Relaxation (FAR) Systems Thinking Approach. Despite an enviable national security condition, Australia is at risk in an information-abundant world that increasingly spawns asymmetric threats such as information terrorism. What is needed are enhanced strategic and operational structures to improve the nation's security and ensure sound futures planning. This research focuses on applying the Fie ....Better Planning for and Managing Asymmetric Threats to Australia's Security: Applying the Field Anomaly Relaxation (FAR) Systems Thinking Approach. Despite an enviable national security condition, Australia is at risk in an information-abundant world that increasingly spawns asymmetric threats such as information terrorism. What is needed are enhanced strategic and operational structures to improve the nation's security and ensure sound futures planning. This research focuses on applying the Field Anomaly Relaxation (FAR) systems thinking approach to asymmetric information warfare threats to Australia. This is a new approach previously developed by ECU researchers investigating risk and innovation in the armed forces. It will now be extended to improve professional practice and the knowledge and skill base of Australia's information defence practitioners.Read moreRead less
Advanced Electromagnetic Sensors and Magnetic Gradiometers for Natural Resources Exploration and Future Space Missions. Australia will benefit from the long-standing world-class mining exploration industry. The new magnetic gradiometer system would greatly enhance their arsenal of geophysical exploration tools, especially for the detection of both magnetically and/or conductive minerals like nickel sulphide. Due to the inherent skin depth issues of conductive cover, a unique condition in Austral ....Advanced Electromagnetic Sensors and Magnetic Gradiometers for Natural Resources Exploration and Future Space Missions. Australia will benefit from the long-standing world-class mining exploration industry. The new magnetic gradiometer system would greatly enhance their arsenal of geophysical exploration tools, especially for the detection of both magnetically and/or conductive minerals like nickel sulphide. Due to the inherent skin depth issues of conductive cover, a unique condition in Australia, a low frequency electromagnetic survey system is one of the best methods to penetrate the cover and investigate deeper geological structures. The low frequency isolation system developed in this project will improve the survey instrument performance down to 4Hz, providing capability to explore resources about 50-100% deeper than existing instrumentation allows.Read moreRead less
Experiments with Advanced Isolation Systems, Suspension and Test Masses Using ACIGA's High Optical Power Test Facility. This proposal will allow experimental verification of the performcane of of sapphire test masses and their associated isolation and suspension system in ACIGA's high optical power test facility at Gingin. The work will contribute to the worldwide effort to increase the sensitivity of laser interferometers to the level where known sources of gravitational waves can be detected ....Experiments with Advanced Isolation Systems, Suspension and Test Masses Using ACIGA's High Optical Power Test Facility. This proposal will allow experimental verification of the performcane of of sapphire test masses and their associated isolation and suspension system in ACIGA's high optical power test facility at Gingin. The work will contribute to the worldwide effort to increase the sensitivity of laser interferometers to the level where known sources of gravitational waves can be detected at a reasonable rate.Read moreRead less
Novel High-Q Resonant Structures for Space and Telecommunications. High-Q microwave resonators with low spurious mode density have important applications in telecommunications, radar, navigation, precision metrology and time standards. We will develop high-Q resonators by constructing a dielectric Bragg resonators using monocrystalline sapphire loaded in a copper cavity with new cylindrical and spherical geometries. Based on these devices, compact and economical state-of-the-art ultra-low noise ....Novel High-Q Resonant Structures for Space and Telecommunications. High-Q microwave resonators with low spurious mode density have important applications in telecommunications, radar, navigation, precision metrology and time standards. We will develop high-Q resonators by constructing a dielectric Bragg resonators using monocrystalline sapphire loaded in a copper cavity with new cylindrical and spherical geometries. Based on these devices, compact and economical state-of-the-art ultra-low noise microwave oscillators and hydrogen masers will be built for the telecommunications market and space applications.Read moreRead less
High Performance Microwave Oscillators for Radars, Comminication Systems and Precision Noise Measurements. The aim of the project is to develop a new class of microwave oscillators with unique combination of properties including low-noise, high frequency stability and reduced sensitivity to vibration. Such oscillators are essential for expanding fields of radar, fiber optics, optical frequency synthesis and metrology.
The industrial partner's focus will be on demands for reduced cost and impro ....High Performance Microwave Oscillators for Radars, Comminication Systems and Precision Noise Measurements. The aim of the project is to develop a new class of microwave oscillators with unique combination of properties including low-noise, high frequency stability and reduced sensitivity to vibration. Such oscillators are essential for expanding fields of radar, fiber optics, optical frequency synthesis and metrology.
The industrial partner's focus will be on demands for reduced cost and improved environmental performance, the university team will focus on improved frequency stability, optimal tuning and novel vibration immunity techniques.
Achieving the project goals will broaden the international markets for the industry partner's products and lead to increased export income for Australia.
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Development of Optical Clocks and Their Applications to Precision Frequency Measurements and Time Keeping. The goal of the proposed international researcher exchange program is to enhance the ongoing collaboration between the Frequency Standards and Metrology (FSM) Group at the University of Western Australia and leading US research institutions, including National Institute of Standards and Technology (NIST) in the field of (i) laser cooled atomic frequency standards, (ii) methods of optical ....Development of Optical Clocks and Their Applications to Precision Frequency Measurements and Time Keeping. The goal of the proposed international researcher exchange program is to enhance the ongoing collaboration between the Frequency Standards and Metrology (FSM) Group at the University of Western Australia and leading US research institutions, including National Institute of Standards and Technology (NIST) in the field of (i) laser cooled atomic frequency standards, (ii) methods of optical frequency synthesis and coherent time transfer between widely separated parts of electromagnetic spectrum and (iii) generation of low noise microwave signals directly from frequency stabilised ultra-fast pulsed lasers.Read moreRead less
Understanding and Costing Offending Trajectories: Creating an Evidence-Base for Targeting Crime Prevention. The research will provide an evidence-base for targeting diversionary and crime prevention programs and for assessing their cost-effectiveness. Many of these programs have resulted in a range of beneficial outcomes and they are receiving increased government funding. By providing a better understanding of offending pathways, the research will enable programs to be targeted towards particul ....Understanding and Costing Offending Trajectories: Creating an Evidence-Base for Targeting Crime Prevention. The research will provide an evidence-base for targeting diversionary and crime prevention programs and for assessing their cost-effectiveness. Many of these programs have resulted in a range of beneficial outcomes and they are receiving increased government funding. By providing a better understanding of offending pathways, the research will enable programs to be targeted towards particular at-risk groups at crucial developmental phases. The innovative longitudinal costing method that will be developed and applied in the Queensland context will enable an assessment of the cost-effectiveness of diversionary and crime prevention programs. This will provide a sound empirical basis for directing scarce government resources.Read moreRead less