Role Of Brm In Skin Tumour Progression From Benign To Malignant
Funder
National Health and Medical Research Council
Funding Amount
$457,267.00
Summary
Australia has the highest incidence of skin cancer in the world. Skin cancer is 3 times as common as all other cancers combined and continues to increase in incidence, particularly in the aging population. Skin cancer is caused by exposure to the ultraviolet radiation found in sunlight. Ultraviolet radiation causes the appearance of solar keratosis, or sunspots, benign lesions that are not particularly dangerous to human health. Some of these develop into malignant squamous cell carcinomas that ....Australia has the highest incidence of skin cancer in the world. Skin cancer is 3 times as common as all other cancers combined and continues to increase in incidence, particularly in the aging population. Skin cancer is caused by exposure to the ultraviolet radiation found in sunlight. Ultraviolet radiation causes the appearance of solar keratosis, or sunspots, benign lesions that are not particularly dangerous to human health. Some of these develop into malignant squamous cell carcinomas that can spread to other tissues and are potentially fatal. Little is known about the biological mechanisms involved in solar keratosis development into squamous cell carcinomas. We have identified the gene brm as being involved in this process. It has not previously been recognised that this gene is important for skin cancer development and therefore our preliminary studies have identified a potential new target. We will study the role of this gene in ultraviolet radiation induced skin carcinogenesis, determine whether it is mutated by ultraviolet radiation in human skin cancer, and what role in plays in some key biological processes in skin cancer development. This study will expand our understanding of malignant conversion during human skin carcinogenesis, the most prevalent human cancer in Australia.Read moreRead less
Molecular Fingerprinting: Forensic Spectroscopy of Trace Gases. Safeguarding Australia from terrorism, crime and invasive diseases is essential to securing our national infrastructure. This project will develop national capabilities in anticipating and responding to critical threats to society. The scientific instrumentation developed from this effort will enhance Australia's potential aid for early detection of explosive and chemical weaponry and also in the analysis of crime scenes. This rese ....Molecular Fingerprinting: Forensic Spectroscopy of Trace Gases. Safeguarding Australia from terrorism, crime and invasive diseases is essential to securing our national infrastructure. This project will develop national capabilities in anticipating and responding to critical threats to society. The scientific instrumentation developed from this effort will enhance Australia's potential aid for early detection of explosive and chemical weaponry and also in the analysis of crime scenes. This research will significantly improve our abilities to maintain the operational advantage of Australia's security agencies through superior capabilities in threat detection.Read moreRead less
Precision Nanomedicine-based Diagnostics And Therapeutics For Refractory Malignancies
Funder
National Health and Medical Research Council
Funding Amount
$7,329,484.00
Summary
The vast majority of cancer patients die of their disease due to the emergence of drug resistant cancer cells or metastatic disease that is diagnosed at late stages. Our program aims to develop new types of therapy to specifically target aggressive cancers. To detect cancer early and evaluate the effectiveness of cancer therapy, we will develop sensitive diagnostic tools and devices. This research has application to both childhood and adult cancers.
The Characterisation of Fires in Tunnels. A series of 22 fires ranging from 2 megawatt up to 20 megawatt intensity will be set under controlled conditions in unused tunnel facilities, in New South Wales. Instrumentation in the tunnel, donated by the State Rail Authority of New South Wales, will monitor the movement of particulates (smoke). This information is vital to tunnel design, and for passenger life safety. This information will be applicable to all tunnels worldwide.
Development of a Compartment Fire Behaviour Training (CFBT) Database. In recent years, incidents of fire flashover have caused considerable destruction to property and the loss of life. Fire prediction and understanding is an area of significance to both the Australian public and the firefighting profession. The NSW Fire Brigade has recently introduced Compartment Fire Behaviour Training (CFBT). To extend this scheme, a database of configurations will be developed using computational modelling, ....Development of a Compartment Fire Behaviour Training (CFBT) Database. In recent years, incidents of fire flashover have caused considerable destruction to property and the loss of life. Fire prediction and understanding is an area of significance to both the Australian public and the firefighting profession. The NSW Fire Brigade has recently introduced Compartment Fire Behaviour Training (CFBT). To extend this scheme, a database of configurations will be developed using computational modelling, allowing firefighters the ability to experience virtually different situations. Detailed experimental studies will be conducted to validate the numerical model. This database will have use and significance beyond Australia and successful implementation promises reductions in the loss of life and property.Read moreRead less
Experimental and numerical study of sprinklers for improved fire safety. Fire sprinklers are a common method for extinguishing fires. Current lack of detailed knowledge about sprinklers can lead to conservative design and excessive cost, often limiting the installation of these proven life-saving devices. This project sees the involvement of Arup Pty Ltd and the NSW Fire Brigade in examining the behaviour of sprinklers using a custom-designed test-rig, laser based measurement and a numerical mod ....Experimental and numerical study of sprinklers for improved fire safety. Fire sprinklers are a common method for extinguishing fires. Current lack of detailed knowledge about sprinklers can lead to conservative design and excessive cost, often limiting the installation of these proven life-saving devices. This project sees the involvement of Arup Pty Ltd and the NSW Fire Brigade in examining the behaviour of sprinklers using a custom-designed test-rig, laser based measurement and a numerical model. This will result in improved confidence in sprinkler specification and installation and the project will have use and significance beyond Australia. Successful implementation promises reductions in the loss of life and property as well as financial savings.Read moreRead less
Resolving Human Immunodeficiency Virus (HIV) Transmission
Funder
National Health and Medical Research Council
Funding Amount
$745,213.00
Summary
To increase the breadth of HIV prevention strategies, it is imperative that we biologically understand how HIV enters our bodies. Through two unique clinical cohorts, we will determine why circumcision is protective and how a commonly acquired sexual transmitted infection (human papilloma virus) can increase HIV transmission.
Unified analysis of steel and composite frame structures subjected to static, thermal, earthquake and blast loading. Understanding the science of extreme loading on engineering structures is essential for their design, and increasingly with terrorism threats there is a need for assessment and strengthening of identified vulnerable critical infrastructure. Rational design paradigms have not yet matured for extreme load scenarios, and they are much-needed to protect life, limb and amenity. Austral ....Unified analysis of steel and composite frame structures subjected to static, thermal, earthquake and blast loading. Understanding the science of extreme loading on engineering structures is essential for their design, and increasingly with terrorism threats there is a need for assessment and strengthening of identified vulnerable critical infrastructure. Rational design paradigms have not yet matured for extreme load scenarios, and they are much-needed to protect life, limb and amenity. Australian research is at the forefront in steel and composite structures, and this project will strengthen Australia's positioning in the discipline by developing transparent design and assessment procedures from an efficient algorithm that delivers hands-on guidance for engineering practitioners.Read moreRead less
Advanced analysis, behaviour and design of steel and steel-concrete composite engineering structures subjected to elevated temperatures. This Fellowship aims to develop a consistent advanced nonlinear method for the analysis and behaviour of steel and composite building frames that are subjected to elevated temperatures. There is widespread feeling amongst practitioners that, in the absence of reliable techniques for verifying this behaviour, the regulatory need for fire protection of steel is ....Advanced analysis, behaviour and design of steel and steel-concrete composite engineering structures subjected to elevated temperatures. This Fellowship aims to develop a consistent advanced nonlinear method for the analysis and behaviour of steel and composite building frames that are subjected to elevated temperatures. There is widespread feeling amongst practitioners that, in the absence of reliable techniques for verifying this behaviour, the regulatory need for fire protection of steel is excessive, and the high expense involved in providing this protection is leading structural steel being rejected in engineering design. This growing trend is leading to a potential downturn in structural steel production, which has serious economic and social ramifications on Australian communities whose fabric is centred on this activity.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0560658
Funder
Australian Research Council
Funding Amount
$481,533.00
Summary
Shared Laser Facility. The Australian Shared Laser Facility (ASLF) has been providing lasers for physical chemistry research for a decade. ASLF lasers are portable and are transported between participating laboratories according to need and research priorities. Funds are sought to expand the ASLF by 3 laser systems and 2 research groups. The requested lasers provide mid-IR and deep UV wavelengths, spectral regions inaccessible with existing ASLF lasers. Access to these wavelengths is essenti ....Shared Laser Facility. The Australian Shared Laser Facility (ASLF) has been providing lasers for physical chemistry research for a decade. ASLF lasers are portable and are transported between participating laboratories according to need and research priorities. Funds are sought to expand the ASLF by 3 laser systems and 2 research groups. The requested lasers provide mid-IR and deep UV wavelengths, spectral regions inaccessible with existing ASLF lasers. Access to these wavelengths is essential for Australian research to remain at the forefront of international physical chemistry research. ASLF laboratories support a wide range of chemical research including spectroscopy, environmental chemistry, astrochemistry, and exploration of nanostructured materials.Read moreRead less