Estimating And Alleviating The Impacts Of Age-Related Sensory Decline
Funder
National Health and Medical Research Council
Funding Amount
$323,767.00
Summary
Sensory loss and dementia disproportionately affect older adults, often co-occur, and are the two leading contributors to disability burden among older Australians. This research will investigate the consequences that hearing and vision loss have for older adult health and wellbeing, informing strategies to reduce the disability burden of age-related sensory loss. These impacts include cognitive decline and dementia, mental health, quality of life, disability and independent living.
Mechanisms And Therapies In Cardiovascular Disease
Funder
National Health and Medical Research Council
Funding Amount
$8,360,700.00
Summary
Cardiovascular disease (CVD) claims 1 person every 10 min in Australia and causes 1 in 3 deaths worldwide. The molecular and cellular processes underlying atherosclerosis, vascular injury and thrombosis are highly complex and not well understood. A multifaceted approach is needed to effectively address these key challenges. This Program brings together world experts in these areas to interrogate gaps in our basic understanding of CVD, and to develop novel therapies for CVD patients by exploiting ....Cardiovascular disease (CVD) claims 1 person every 10 min in Australia and causes 1 in 3 deaths worldwide. The molecular and cellular processes underlying atherosclerosis, vascular injury and thrombosis are highly complex and not well understood. A multifaceted approach is needed to effectively address these key challenges. This Program brings together world experts in these areas to interrogate gaps in our basic understanding of CVD, and to develop novel therapies for CVD patients by exploiting new knowledge through integrated research.Read moreRead less
Ocular Motility In Autism And Asperger S Disorder: Dissociation Of Motor Deficits.
Funder
National Health and Medical Research Council
Funding Amount
$131,235.00
Summary
We will use ocular motor technology to investigate motor dysfunction in autism and Asperger's disorder, to advance our understanding of the neurobiological bases of these disorders. This will help clarify whether neural networks are differentially disrupted in these disorders, as our previous clinical research suggests. This dissociation and the subsequent development of an ocular motor clincal screen may improve diagnosis, and potentially treatment, of these devastating conditions.
TELEPHONE COUNSELLING FOR MAINTENANCE OF PHYSICAL ACTIVITY, WEIGHT LOSS And GLYCAEMIC CONTROL IN TYPE 2 DIABETES
Funder
National Health and Medical Research Council
Funding Amount
$1,285,894.00
Summary
Regular exercise, a healthy diet and weight loss are key to managing type 2 diabetes, yet these are major challenges for most people with diabetes. This study will evaluate the impact of a telephone counselling program to assist people with type 2 diabetes to exercise, eat a healthy diet and lose weight, with the goal of helping them to sustain these changes over the long-term. It is expected that these lifestyle changes will also result in improved blood glucose control and quality of life.
Motor Functioning In Young People With Attention Deficit Hyperactivity Disorder – Combined Type: A Three-dimensional Motion Analysis Study.
Funder
National Health and Medical Research Council
Funding Amount
$477,065.00
Summary
Attention deficit hyperactivity disorder –combined type (ADHD-CT) is a complex neuropsychiatric disorder with a progressively devastating impact on psychosocial development. The first objective of this study is to use 3D-motion analysis to ‘probe’ the underlying brain dysfunction which characterises ADHD-CT. The second objective of this study is to improve our understanding of the link between movement problems, and (a) injury proneness, and (b) social-communicative problems, in children with AD ....Attention deficit hyperactivity disorder –combined type (ADHD-CT) is a complex neuropsychiatric disorder with a progressively devastating impact on psychosocial development. The first objective of this study is to use 3D-motion analysis to ‘probe’ the underlying brain dysfunction which characterises ADHD-CT. The second objective of this study is to improve our understanding of the link between movement problems, and (a) injury proneness, and (b) social-communicative problems, in children with ADHD-CT.Read moreRead less
Renewable energy generation from flow-induced vibration. Much engineering effort has been expended to eliminate vibration of marine structures. This project seeks to provide the basis for the development of tidal energy harnessing, by deliberately amplifying and harnessing vibration. This technology offers the promise of capturing clean, zero-emissions energy, while presenting no risk to marine life.
Using Health Outcome Data From Pooled Longitudinal Studies Of Ageing To Develop Statistical And Microsimulation Models T
Funder
National Health and Medical Research Council
Funding Amount
$2,162,630.00
Summary
This project draws together data from nine Australian Longitudinal Studies of Ageing (LSAs), including 53484 participants, that will be used to identify factors capable of preventing disease, reducing ill-health, and promoting engaged and successful ageing for Australians. The focus is upon conditions that significantly contribute to the burden of disease including cognitive decline and dementia, sensory impairment, impairment in mobility and common mental disorders such as depression. Although ....This project draws together data from nine Australian Longitudinal Studies of Ageing (LSAs), including 53484 participants, that will be used to identify factors capable of preventing disease, reducing ill-health, and promoting engaged and successful ageing for Australians. The focus is upon conditions that significantly contribute to the burden of disease including cognitive decline and dementia, sensory impairment, impairment in mobility and common mental disorders such as depression. Although individual studies contain rich data on particular topics, there is only a small number of individuals in each study with specific medical conditions, or combinations of different conditions, especially at the older ages. Pooling data from nine studies will overcome this problem. This innovative and interdisciplinary study also involves development of the first Australian dynamic micro-simulation model of the health and social outcomes of the baby boomer and older cohorts. The simulation will allow for evaluation of the impact of modifying risk factors, and costs associated with different trajectories of health and ageing. Our program takes an interdisciplinary life course approach, incorporating interdependencies among demographic, behavioural, social, economic and health factors. Our multidisciplinary team and collaborative pooling of existing studies adds value and builds upon experience, as recommended in the Prime Minister's Science, Engineering and Innovation Council 2003 report. The outcomes will direct health and social policy to promote health behaviour, and social and medical interventions to compress morbidity and optimize healthy ageing in Australian society over the next 40 years.Read moreRead less
We have discovered a single tumour factor which causes cancer cachexia, a wasting condition that is one of the worst complications of malignancy, for which there is no current effective treatment. We have developed antibodies which effectively block this condition in preclinical models and have produced human/humanised version of this. This application is to characterise these human antibodies to allow us proceed to clinical trials.
Applying search theory for eradicating invasive species. Invasive species have major economic and environmental impacts in Australia and are a major cause of extinctions worldwide. Monitoring is crucial for the timely control of invasive species in sensitive environments. Early detection increases the probability of eradication and increased accuracy in detection reduces the impact of control programs on non-target species. Efficient monitoring also is crucial in determining whether eradication ....Applying search theory for eradicating invasive species. Invasive species have major economic and environmental impacts in Australia and are a major cause of extinctions worldwide. Monitoring is crucial for the timely control of invasive species in sensitive environments. Early detection increases the probability of eradication and increased accuracy in detection reduces the impact of control programs on non-target species. Efficient monitoring also is crucial in determining whether eradication has succeeded. Search Theory has been applied for over 60 years in a wide range of non-biological monitoring problems, resulting in large increases in target detection rates. Gains of a similar magnitude in invasive species detection would greatly enhance Australia's capacity to manage these threats.Read moreRead less
Automatic control systems for low-energy pipelines in irrigation networks. Automatic control systems for low-energy pipelines in irrigation networks. This project aims to design automated pipelines to distribute irrigation water from backbone open-channels to end-users. Automation can make irrigation networks more efficient, which is important for food security and the environment. Automation is expected to achieve low-energy distribution, in line with the gravity-powered operation of typical op ....Automatic control systems for low-energy pipelines in irrigation networks. Automatic control systems for low-energy pipelines in irrigation networks. This project aims to design automated pipelines to distribute irrigation water from backbone open-channels to end-users. Automation can make irrigation networks more efficient, which is important for food security and the environment. Automation is expected to achieve low-energy distribution, in line with the gravity-powered operation of typical open-channel networks. The main challenges are the development of suitable models for designing outlet-flow control systems, optimization-based outlet-flow scheduling methods for ensuring operation within hydraulic constraints, and system monitoring techniques. This project will design automatic control systems to enable low-energy water distribution from open-channels to end-users by pipes.Read moreRead less