Hedgehog Signalling In Limb And Craniofacial Development And Disease
Funder
National Health and Medical Research Council
Funding Amount
$494,544.00
Summary
Anomalies of the face and limbs are amongst the most common features of human birth defects, and their frequent association suggests that the same genes are involved in governing the development of the limbs and face during embryogenesis. We have used a genomics-based approach to identify genes involved in limb development based on their alteration in a mouse model which develops extra fingers and toes. Defects in this mouse result from changes in Gli3, a gene which is known to be important in b ....Anomalies of the face and limbs are amongst the most common features of human birth defects, and their frequent association suggests that the same genes are involved in governing the development of the limbs and face during embryogenesis. We have used a genomics-based approach to identify genes involved in limb development based on their alteration in a mouse model which develops extra fingers and toes. Defects in this mouse result from changes in Gli3, a gene which is known to be important in both limb and face development. Based on the organs in which our genes of interest are active, we believe that they will also play key roles in embryonic development of the limbs, face and other organs. We now plan to investigate the regulation of a subset of these genes based on analysis in mouse models of limb and face development. In addition, we have chosen to further analyse the function of a completely novel gene we have identified which our preliminary studies suggest may play a role in the normal development of the lip and palate. These studies have the potential to shed light on the processes governing how organs develop, as well as on the molecular basis of common birth defects such as polydactyly (extra fingers and toes) and cleft palate.Read moreRead less
Removing the impediment to large-scale selective breeding of Australian barramundi: deciphering and manipulating the genetic basis of sex change. This project will determine the genetic basis of sex control in barramundi and develop technologies to allow barramundi hatcheries to have increased control over reproduction leading to more efficient propagation and removing impediments to selective breeding.
Striking Gold - Determining the genetics of gold skin colour in barramundi. Barramundi is one of Australia’s finest eating table fish and the species is gaining global prominence. However, fillet flesh colour of Australian farmed barramundi exhibit greyish tones which lowers consumer acceptance compared to other white flesh fish and imported product. Barramundi with rare golden skin tones do not exhibit this flesh "greyness" and are therefore a valuable niche product to farm if they can be produ ....Striking Gold - Determining the genetics of gold skin colour in barramundi. Barramundi is one of Australia’s finest eating table fish and the species is gaining global prominence. However, fillet flesh colour of Australian farmed barramundi exhibit greyish tones which lowers consumer acceptance compared to other white flesh fish and imported product. Barramundi with rare golden skin tones do not exhibit this flesh "greyness" and are therefore a valuable niche product to farm if they can be produced in larger numbers. This project will elucidate the genetic basis and mechanism of expression behind the golden barramundi phenotype. In doing so, it will enable barramundi farmers to produce them at commercially relevant scales, providing them with a substantial competitive advantage in both domestic and global markets.Read moreRead less
Industrial Transformation Research Hubs - Grant ID: IH210100014
Funder
Australian Research Council
Funding Amount
$4,996,503.00
Summary
ARC Research Hub for Supercharging Tropical Aquaculture Through Genetic Solutions. This project will deliver the genetic knowledge to instigate world-leading and highly productive breeding programs for five tropical aquaculture species (barramundi, pearl oyster, prawn, grouper and marine algae) in northern Australia. It will integrate cutting edge genetic and genomic approaches into innovative aquaculture enterprises and will establish a novel understanding of the genetic basis of disease resist ....ARC Research Hub for Supercharging Tropical Aquaculture Through Genetic Solutions. This project will deliver the genetic knowledge to instigate world-leading and highly productive breeding programs for five tropical aquaculture species (barramundi, pearl oyster, prawn, grouper and marine algae) in northern Australia. It will integrate cutting edge genetic and genomic approaches into innovative aquaculture enterprises and will establish a novel understanding of the genetic basis of disease resistance and how the production environment interfaces with the bacterial microbiome, pathogens and water quality to cause disease. Outcomes will lead to increased productivity, international competitiveness, and lowered disease risk and significantly expand Australia's capacity in the aquaculture sector.Read moreRead less
Fighting disease on farms: how do vaccinations drive evolution of new pathogen strains? Vaccinating against some types of infectious diseases can drive evolution of new variants of the pathogen. This project will show how bacterial populations evolve in response to vaccination in farms, leading to new vaccination strategies and improved vaccine formulations to better control diseases that are caused by highly variable bacteria.
A pan-genome reverse vaccinology approach to disease prevention in farmed fish. Evolution of new pathogen strains causes major problems in vaccinated animals because these variants can reinfect and cause severe disease in previously protected animals. This project will use state-of-the-art genomics to find new targets that are essential to all strain variants, enabling development of broadly cross-protective vaccines for farmed animals.
Early Career Industry Fellowships - Grant ID: IE230100648
Funder
Australian Research Council
Funding Amount
$472,027.00
Summary
Novel reproductive approaches to de-risk and transform barramundi breeding. Demand for Australian seafood outstrips supply. Farming of the iconic Australian barramundi is poised to play a major role addressing this shortfall; but innovative methods are needed to de-risk breeding processes and to provide precise control of maturation, spawning and genetic contribution of broodstock. This project, in partnership with the world’s largest barramundi breeding company, will develop, test and apply nov ....Novel reproductive approaches to de-risk and transform barramundi breeding. Demand for Australian seafood outstrips supply. Farming of the iconic Australian barramundi is poised to play a major role addressing this shortfall; but innovative methods are needed to de-risk breeding processes and to provide precise control of maturation, spawning and genetic contribution of broodstock. This project, in partnership with the world’s largest barramundi breeding company, will develop, test and apply novel breeding methods to obtain tight control over barramundi reproductive development and spawning. By combining cutting-edge genetic and applied breeding techniques, selective breeding programs will be more efficient and the genetic gains from breeding programs will be maximised.Read moreRead less
Alternate diets for a sustainable aquaculture industry: neuroethology of feeding in barramundi. Our unique approach to identify the sensory requirements of farmed barramundi and develop new alternative feeds will 1. Improve barramundi production by increasing growth rates, 2. Enhance acceptance and ingestion of food pellets, thereby reducing leaching of nutrients vital to the fish and detrimental to the environment, 3. Help produce formulated diets that will offer the advantages of nutritional c ....Alternate diets for a sustainable aquaculture industry: neuroethology of feeding in barramundi. Our unique approach to identify the sensory requirements of farmed barramundi and develop new alternative feeds will 1. Improve barramundi production by increasing growth rates, 2. Enhance acceptance and ingestion of food pellets, thereby reducing leaching of nutrients vital to the fish and detrimental to the environment, 3. Help produce formulated diets that will offer the advantages of nutritional consistency, storage convenience, reduced feed waste and pollution and 4. Lower costs allowing for the successful and profitable production of barramundi and potentially other finfish. Read moreRead less
Aquaculture of the tropical abalone: identifying and selecting for factors promoting high settlement, survival and growth. There is a growing demand worldwide for the 'cocktail'-sized tropical abalone Haliotis asinina. We have developed a full set of hatchery and grow-out procedures that Queensland Sea Scallops Pty Ltd will test on a commercial scale. At QSS, we will propagate and growout Haliotis asinina to determine the factors controlling settlement, survival, growth and health. We will do ....Aquaculture of the tropical abalone: identifying and selecting for factors promoting high settlement, survival and growth. There is a growing demand worldwide for the 'cocktail'-sized tropical abalone Haliotis asinina. We have developed a full set of hatchery and grow-out procedures that Queensland Sea Scallops Pty Ltd will test on a commercial scale. At QSS, we will propagate and growout Haliotis asinina to determine the factors controlling settlement, survival, growth and health. We will do this by combining breeding experiments with microarray gene profiling and other advanced gene expression studies. This knowledge will enhance the development of this new aquaculture industry in tropical Australia and our understanding of abalone aquaculture in general.Read moreRead less
An investigation of the underlying mechanisms that control gender and fertility in the Moreton Bay Bug, Thenus orientalis. To date there is no available information on the underlying biochemical and genetic mechanisms that control gender and fertility in Thenus spp. Understanding how gender and fertility are controlled in this lobster species will allow development of technologies to exploit desired commercial traits such as reproductive sterility (for genetic protection). Such technologies wil ....An investigation of the underlying mechanisms that control gender and fertility in the Moreton Bay Bug, Thenus orientalis. To date there is no available information on the underlying biochemical and genetic mechanisms that control gender and fertility in Thenus spp. Understanding how gender and fertility are controlled in this lobster species will allow development of technologies to exploit desired commercial traits such as reproductive sterility (for genetic protection). Such technologies will facilitate rapid uptake of commercial culture of this high-value species in Australia and establishment of international markets. Read moreRead less