Motor Functioning In Young People With Attention Deficit Hyperactivity Disorder – Combined Type: A Three-dimensional Motion Analysis Study.
Funder
National Health and Medical Research Council
Funding Amount
$477,065.00
Summary
Attention deficit hyperactivity disorder –combined type (ADHD-CT) is a complex neuropsychiatric disorder with a progressively devastating impact on psychosocial development. The first objective of this study is to use 3D-motion analysis to ‘probe’ the underlying brain dysfunction which characterises ADHD-CT. The second objective of this study is to improve our understanding of the link between movement problems, and (a) injury proneness, and (b) social-communicative problems, in children with AD ....Attention deficit hyperactivity disorder –combined type (ADHD-CT) is a complex neuropsychiatric disorder with a progressively devastating impact on psychosocial development. The first objective of this study is to use 3D-motion analysis to ‘probe’ the underlying brain dysfunction which characterises ADHD-CT. The second objective of this study is to improve our understanding of the link between movement problems, and (a) injury proneness, and (b) social-communicative problems, in children with ADHD-CT.Read moreRead less
Improving Neurodevelopmental Outcomes Of Preterm Infants
Funder
National Health and Medical Research Council
Funding Amount
$312,085.00
Summary
In Australia over 20,000 babies are born preterm each year. Preterm babies are at risk of long term developmental problems including movement, learning and behavioural impairments. This research will examine both neurodevelopment and brain development of very preterm (born <30 weeksÍ gestation) and late preterm (32-36 weeksÍ gestation) babies from birth to into early childhood so that we can understand how gestational age at birth relates to development, brain growth and interventions.
VicCPchild- Prospective Cohort Study Of Children With Cerebral Palsy
Funder
National Health and Medical Research Council
Funding Amount
$613,587.00
Summary
Cerebral palsy is the most common cause of physical disability in children affecting 1 in 500 young Australians. While the brain lesion is static, the musculoskeletal problems are progressive and require lifelong management (cost of US$946,000 over life per person). Only large prospective population-based studies give a true indication of the incidence of physical problems, determine the pathway(s) to outcome and determine the best pathways to successful treatment and efficient resource allocati ....Cerebral palsy is the most common cause of physical disability in children affecting 1 in 500 young Australians. While the brain lesion is static, the musculoskeletal problems are progressive and require lifelong management (cost of US$946,000 over life per person). Only large prospective population-based studies give a true indication of the incidence of physical problems, determine the pathway(s) to outcome and determine the best pathways to successful treatment and efficient resource allocation. The broad aim of this project is: This population based cohort study (n - 240) aims to determine the pathway to motor outcome from diagnosis at 18 months to 5 years based on the nature of the brain injury at 24 months (structural MRI of the nature, location and timing of the brain lesion). Secondary Aims: Determine the rate of musculoskeletal deformity (hip displacement, spasticity, muscle contracture). Potential impact of medical co-morbidities (nutrition, epilepsy, respiratory problems) Patterns of participation and HRQOL. Patterns of medical resource use: treatment costs and outcomes. This study will: Allow clinicians to better the likely functional outcomes of children with CP from an earlier age based on the rate and limit of gross motor development and nature and severity of the brain lesion, determine the nature and timing of physical deformities to aid prevention and treatment; provide information on resource use for future planning and organisation of medical and therapy services. This in turn will give more accurate prognostic counseling as well as target areas for early therapy. Our multidisciplinary research group is uniquely placed to conduct this world-first study with access to two entire birth years of children linked to our Victorian Cerebral Palsy Register. Recruitment is conducted at both the Royal Children's Hospital and the Monash Medical centre in order to ensure state wide referral and easy access for families.Read moreRead less
Infant Motor Development Between 0-4 Months: A New Look At The Effect Of The ‘back To Sleep’ Program
Funder
National Health and Medical Research Council
Funding Amount
$107,182.00
Summary
An unexpected consequence of the Back to Sleep program is an increased incidence of deformational plagiocephaly (DP), or “flat head syndrome”, and concern about delayed development. It is not clear whether the current recommendation to provide ‘tummy-time’ play for infants when awake is the best way to prevent DP. Development of typical infants 0-4 months and infants with DP will be investigated and parents surveyed as a basis for development and trialling of a new DP prevention initiative.
Motor problems, ranging from clumsiness to cerebral palsy, are one of the most common adverse outcomes in children born early. This study will investigate the motor development of children born <30 weeks’ gestation compared with peers born at term from birth to 5 years. We will determine whether early clinical evaluations or neuroimaging in the newborn period can predict later motor impairment at 5 years to be able to identify those who will benefit most from early intervention.
Preclinical Development Of Complement C5aR Antagonists For The Treatment Of Motor Neuron Disease
Funder
National Health and Medical Research Council
Funding Amount
$593,326.00
Summary
There is no cure for Motor Neuron Disease (MND) resulting in 2 Australian’s dying each day. Modification of the inflammation is one potential means of slowing MND. Our research team has identified a new series of potent anti-inflammatory compounds that may have potential to treat this disease. Our project will test these compounds in animal models of MND, and validate their usefulness in human MND samples. Ultimately, this work may contribute to the discovery of a new treatment for MND.
Optimising The Motor Outcomes Of Infants With Cerebral Palsy Using Environmental And Goal Oriented Interventions
Funder
National Health and Medical Research Council
Funding Amount
$116,563.00
Summary
Cerebral palsy is the most common physical disability in childhood. Early diagnosis enables intervention when the brain is developing. Current early intervention has little impact on movement. This research tests the effectiveness of “goal-directed training” and enriched environments by: systematically reviewing literature, piloting the intervention, conducting a clinical trial and interviewing parents. Findings have the potential to improve the outcomes of the 700 new cases diagnosed each year.
The Neurophysiology Of Abnormal Motor Development In Preterm Children
Funder
National Health and Medical Research Council
Funding Amount
$479,967.00
Summary
Better neonatal care has improved survival of prematurely born children. While most of these children will have no obvious brain lesion and attend mainstream schools, many will experience motor and cognitive difficulties and problems with social adjustment. However, the physiological mechanisms underlying this dysfunction are unknown. We will study preterm and term born children to elucidate the physiological mechanisms underlying motor and cognitive dysfunction associated with prematurity.
From Understanding The Mechanisms To Implementing Conservative Management Of Musculoskeletal Conditions
Funder
National Health and Medical Research Council
Funding Amount
$2,339,215.00
Summary
Musculoskeletal pain is the leading cause of disability internationally and outcomes are worsening. This work will take a unique approach to study back pain from the mechanisms that occur at the cellular level to the interaction between a person’s physiology and psychology to understand why pain fluctuates, to understand how treatments can be more appropriately tailored for individuals, and to test how people with back pain can be supported to change behaviours and achieve recovery.