Harnessing Neuroplasticity To Improve Motor Performance In Infants With Cerebral Palsy: A Pragmatic Randomized Controlled Trial
Funder
National Health and Medical Research Council
Funding Amount
$2,736,349.00
Summary
Every 15 hours an Australian baby is born with cerebral palsy. Despite confidence in early intervention, 50% don't receive intervention before their first birthday while awaiting diagnosis, and 8 of 10 previous trials have not produced any physical gains over and above natural development. We have promising data about a new brain training intervention that harnesses neuroplasticity and improves movement. Our trial will treat 300 infants with early training comparing results to Standard Care.
Musculoskeletal injuries sustained as a consequence of road traffic crashes are common and costly to the Australian community. Many people do not recover well after the injury but suffer ongoing pain and disability. The Centre for Research Excellence in Recovery Following Road Traffic Injury will target a clear need to improve health outcomes for injured individuals through research, capacity building and end-user engagement with a focus in primary care.
Urinary continence and incontinence in men: New insight through new technologies. Healthy ageing in men is largely overlooked. Disorders of continence are surprisingly common with increasing age, and are socially debilitating. To understand changes in continence and address healthy ageing it is first necessary to gain an understanding of continence mechanisms in healthy men. Continence in women has received wide attention, but anatomy and function differ, as do the challenges throughout life (ch ....Urinary continence and incontinence in men: New insight through new technologies. Healthy ageing in men is largely overlooked. Disorders of continence are surprisingly common with increasing age, and are socially debilitating. To understand changes in continence and address healthy ageing it is first necessary to gain an understanding of continence mechanisms in healthy men. Continence in women has received wide attention, but anatomy and function differ, as do the challenges throughout life (childbirth vs. prostate disease). Using novel methods we will test a new hypothesis of male continence with the goal to provide new physiological discoveries, new methods, and baseline data upon which strategies to enhance healthy ageing and reduce the economic burden of disorders of continence can be developed and refined. Read moreRead less
Revealing the beneficial effects of acoustic stimulation on the human brain. This project aims to provide greater understanding of the neural mechanisms by which initiation of motor responses can be improved by unexpected auditory stimulation. Initiating motor actions appears natural and effortless, but is underpinned by complex neural mechanisms that are not well understood. Using novel brain stimulation techniques, the project aims to assess the potential for properly timed strong sensory stim ....Revealing the beneficial effects of acoustic stimulation on the human brain. This project aims to provide greater understanding of the neural mechanisms by which initiation of motor responses can be improved by unexpected auditory stimulation. Initiating motor actions appears natural and effortless, but is underpinned by complex neural mechanisms that are not well understood. Using novel brain stimulation techniques, the project aims to assess the potential for properly timed strong sensory stimulation during movement preparation to induce neural plasticity and motor learning. This knowledge would have important implications across a number of fields, including neuroscience, sports science, and applied ergonomics.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE120100653
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
The predictive brain and control of anticipatory actions. The ability to predict events in a dynamic environment is an important skill for survival as it can guide our actions when time pressures are severe. How predictions come about to guide our actions is not clear and project results will have great theoretical significance to understand how we generate them.
Home-based Speech Treatment For Parkinsons Disease Via Telerehabilitation : Clinical And Economic Outcomes.
Funder
National Health and Medical Research Council
Funding Amount
$485,793.00
Summary
Parkinson's Disease affects a person's ability to speak clearly. Speech pathologists can provide effective treatment for this speech disorder. Access to a speech pathologist, however, is difficult for many people with Parkinson's Disease due to their physical difficulties and the limited availability of speech pathology services in rural areas. This study demonstrates the use of telerehabilitation to deliver speech treatment to people with Parkinson's Disease in their own homes via the Internet.
The influence of resistance training upon movement control in the elderly. The primary aim of this applied research project is to investigate the impact of resistance training in the elderly. We will assess the responses to training that occur in the elderly, and determine the time course and persistence of adaptation. It is anticipated that the knowledge derived will be applied by clinicians and health practitioners in the design of resistance training programmes for the elderly, and thereby en ....The influence of resistance training upon movement control in the elderly. The primary aim of this applied research project is to investigate the impact of resistance training in the elderly. We will assess the responses to training that occur in the elderly, and determine the time course and persistence of adaptation. It is anticipated that the knowledge derived will be applied by clinicians and health practitioners in the design of resistance training programmes for the elderly, and thereby enhance the performance of tasks encountered in daily living.Read moreRead less
Spinal complaints present the greatest social and economic burden of musculoskeletal conditions in Australia. This reflects current realities: the cause remains unknown; 80% of the population is affected; and isolated professions perform a staggering array of interventions. The CCRE aims to target these realities and improve Australia's capacity to prevent and manage spinal disorders by supporting innovative interdisciplinary research and training. This community- and university-based centre wil ....Spinal complaints present the greatest social and economic burden of musculoskeletal conditions in Australia. This reflects current realities: the cause remains unknown; 80% of the population is affected; and isolated professions perform a staggering array of interventions. The CCRE aims to target these realities and improve Australia's capacity to prevent and manage spinal disorders by supporting innovative interdisciplinary research and training. This community- and university-based centre will align highly successful clinical and basic researchers in collaboration with a national network of spine scientists to foster interdisciplinary clinical researcher training, develop new diagnostics and therapeutics, and translate findings to the community. Through clinical research the centre aims to: (i) Advance understanding of physiology and pathophysiology of spinal pain (ii) Translate findings from basic research to clinical practice (iii) Establish coordinated multidisciplinary research to reduce the burden of spinal pain (iv) Predict and prevent the transition from acute to chronic states (v) Train a new generation of transdisciplinary clinical scientists (vi) Rapidly assess new treatment possibilities in pre-clinical studies (vii) Develop innovative technologies for diagnostics and therapeutics (viii) Encourage Australian commercialisation opportunities for new discoveries (ix) Encourage community-user participation in direction of research programs (x) Disseminate new findings and information of evidence-based practice to patients, clinicians, insurers, government and the scientific and wider communityRead moreRead less
Subcortical control of human reaching? This project will test a radical new hypothesis about how the human brain generates visually guided behaviour. Conventional thinking assumes that visuomotor control of limb movements occurs exclusively within the cerebral cortex. However, the project team’s recent observations of extremely rapid visually guided muscle activity strongly imply that the human brain controls reaching movements via more primitive midbrain and brainstem structures. The project’s ....Subcortical control of human reaching? This project will test a radical new hypothesis about how the human brain generates visually guided behaviour. Conventional thinking assumes that visuomotor control of limb movements occurs exclusively within the cerebral cortex. However, the project team’s recent observations of extremely rapid visually guided muscle activity strongly imply that the human brain controls reaching movements via more primitive midbrain and brainstem structures. The project’s hypotheses challenge long-standing ideas about the functional organisation of the human brain and may have wide-ranging implications for the design of human-machine interfaces as well as training protocols in rehabilitation, industry, and sport.Read moreRead less
How do past actions and rewards bias goal directed movement? This project aims to identify how different aspects of our past experience affect the accuracy of movements, and study the underlying brain mechanisms. This project will use timing methods and brain recordings to test how the history of movements we have executed in the past, and the rewards associated with those movements, interact to affect subsequent movement execution. The project should advance basic understanding of how the human ....How do past actions and rewards bias goal directed movement? This project aims to identify how different aspects of our past experience affect the accuracy of movements, and study the underlying brain mechanisms. This project will use timing methods and brain recordings to test how the history of movements we have executed in the past, and the rewards associated with those movements, interact to affect subsequent movement execution. The project should advance basic understanding of how the human brain controls movement, and provide theoretical foundations needed to improve the design of human-machine interfaces, and training approaches in industry, rehabilitation and sport.Read moreRead less