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Spinal complaints present the greatest social and economic burden of musculoskeletal conditions in Australia. This reflects current realities: the cause remains unknown; 80% of the population is affected; and isolated professions perform a staggering array of interventions. The CCRE aims to target these realities and improve Australia's capacity to prevent and manage spinal disorders by supporting innovative interdisciplinary research and training. This community- and university-based centre wil ....Spinal complaints present the greatest social and economic burden of musculoskeletal conditions in Australia. This reflects current realities: the cause remains unknown; 80% of the population is affected; and isolated professions perform a staggering array of interventions. The CCRE aims to target these realities and improve Australia's capacity to prevent and manage spinal disorders by supporting innovative interdisciplinary research and training. This community- and university-based centre will align highly successful clinical and basic researchers in collaboration with a national network of spine scientists to foster interdisciplinary clinical researcher training, develop new diagnostics and therapeutics, and translate findings to the community. Through clinical research the centre aims to: (i) Advance understanding of physiology and pathophysiology of spinal pain (ii) Translate findings from basic research to clinical practice (iii) Establish coordinated multidisciplinary research to reduce the burden of spinal pain (iv) Predict and prevent the transition from acute to chronic states (v) Train a new generation of transdisciplinary clinical scientists (vi) Rapidly assess new treatment possibilities in pre-clinical studies (vii) Develop innovative technologies for diagnostics and therapeutics (viii) Encourage Australian commercialisation opportunities for new discoveries (ix) Encourage community-user participation in direction of research programs (x) Disseminate new findings and information of evidence-based practice to patients, clinicians, insurers, government and the scientific and wider communityRead moreRead less
The Contribution Of Dopamine To Regulation Of Orofacial, Limb And Trunk Control: System Or Function Specific Effects?
Funder
National Health and Medical Research Council
Funding Amount
$493,124.00
Summary
Treatment for Parkinson's disease, including dopamine replacement therapy and deep brain stimulation, fail to produce the same beneficial effects on all movement systems. Whereas limb function is the primary beneficiary of these treatments, other functions such as speech and postural control are less responsive. Critical to the research is the postulate that such differences may have arisen due to the fact that previous studies of dopamine and movement control have investigated distinct motor sy ....Treatment for Parkinson's disease, including dopamine replacement therapy and deep brain stimulation, fail to produce the same beneficial effects on all movement systems. Whereas limb function is the primary beneficiary of these treatments, other functions such as speech and postural control are less responsive. Critical to the research is the postulate that such differences may have arisen due to the fact that previous studies of dopamine and movement control have investigated distinct motor systems via the assessment of distinct movement constructs, making cross system comparisons an impossible task. The proposed research will assess the effect of Parkinson's disease, deep brain stimulation and dopamine on identical muscle functions within the orofacial, trunk and limb muscle systems. To this end, the results generated from this resarch have the potential to reconceptualise working models of brain-muscle relationships. Further the research will provide guidance for future studies that aim to eradicate trade-off effects (e.g. limb function improved but not speech) relating to symptom relief for people with Parkinson's disease.Read moreRead less
Physiological And Neurophysiological Assessment Of Lip And Tongue Function For Speech In Multiple Sclerosis
Funder
National Health and Medical Research Council
Funding Amount
$356,250.00
Summary
Speech difficulties are commonly experienced by people with multiple sclerosis (MS) and can have a devastating, restrictive effect on social interactions, work and education opportunities, ultimately reducing quality of life. Research has shown that a major factor underlying impaired speech in MS is disturbed functioning of the structures that articulate speech, particularly the tongue and lips. In order to effectively treat these speech disturbances, it is imperative that the nature and severit ....Speech difficulties are commonly experienced by people with multiple sclerosis (MS) and can have a devastating, restrictive effect on social interactions, work and education opportunities, ultimately reducing quality of life. Research has shown that a major factor underlying impaired speech in MS is disturbed functioning of the structures that articulate speech, particularly the tongue and lips. In order to effectively treat these speech disturbances, it is imperative that the nature and severity of the tongue and lip impairments be identified, so that specific treatment methods can be employed to directly target those impairments. The present project will use state-of-the-art technology to track and record movements of the tongue and lips during speech and to investigate how well the neural command pathways leading from the brain to the lip and tongue muscles are functioning in persons with MS. The results of the study will direct the development of more specific and effective speech therapy procedures that will empower persons with MS with intelligible speech.Read moreRead less