A Longitudinal Neuroimaging Study Investigating Reorganisation Of Cerebellar-cerebral Networks In Friedreich Ataxia
Funder
National Health and Medical Research Council
Funding Amount
$816,908.00
Summary
Friedreich ataxia (FRDA) causes debilitating motor and cognitive deficits. We propose a longitudinal multi-modal magnetic resonance (MR) imaging study to measure different types of tissue in the brain in this disease. We seek to understand how the brain reorganises itself due to cell loss in the spinal cord, cerebellum and cerebral cortex. This study will establish sensitivity of a range of MR imaging measures as potential biomarkers for use in large multi-centre drug trials in this disease.
Ocular Motility In Autism And Asperger S Disorder: Dissociation Of Motor Deficits.
Funder
National Health and Medical Research Council
Funding Amount
$131,235.00
Summary
We will use ocular motor technology to investigate motor dysfunction in autism and Asperger's disorder, to advance our understanding of the neurobiological bases of these disorders. This will help clarify whether neural networks are differentially disrupted in these disorders, as our previous clinical research suggests. This dissociation and the subsequent development of an ocular motor clincal screen may improve diagnosis, and potentially treatment, of these devastating conditions.
The cognitive neuroscience of motor skill learning. The capacity to produce skilled motor behaviour is essential for success in almost every aspect of our lives, whether it be playing sport, driving a car, operating machinery at work, or touch-typing. This project aims to establish the causal role of brain regions in motor skill learning by combining cutting-edge techniques in neuroimaging and brain stimulation. It is expected to lead to fundamental new knowledge on how new motor memories are cr ....The cognitive neuroscience of motor skill learning. The capacity to produce skilled motor behaviour is essential for success in almost every aspect of our lives, whether it be playing sport, driving a car, operating machinery at work, or touch-typing. This project aims to establish the causal role of brain regions in motor skill learning by combining cutting-edge techniques in neuroimaging and brain stimulation. It is expected to lead to fundamental new knowledge on how new motor memories are created to enable the expression of skilled motor behaviour. The knowledge gained from this project may identify new strategies for learning skills that are widely applicable to education, industry, sport, and health.Read moreRead less
Influence of athletic footwear on lower limb biomechanics of pubertal girls. This project aims to determine whether athletic footwear with appropriate design features can help improve neuromuscular control and, in doing so, reduce the potentially deleterious forces on the knee and lower limb structures of pubertal girls. As girls reach puberty, they become less able to control the movement patterns of their lower limbs, particularly in high-demand tasks like running and jumping. Better-designed ....Influence of athletic footwear on lower limb biomechanics of pubertal girls. This project aims to determine whether athletic footwear with appropriate design features can help improve neuromuscular control and, in doing so, reduce the potentially deleterious forces on the knee and lower limb structures of pubertal girls. As girls reach puberty, they become less able to control the movement patterns of their lower limbs, particularly in high-demand tasks like running and jumping. Better-designed footwear for pubertal girls may improve movement patterns, decrease the likelihood of musculoskeletal injury and improve physical activity participation rates. Project outcomes may lead to the development of such footwear, and are also anticipated to expand our understanding of female developmental biomechanics.Read moreRead less
Athletic footwear for reducing knee loads in girls and women. This project aims to develop a novel athletic shoe that can reduce harmful knee loads during sport in adolescent girls and young women. As girls reach puberty, they become less able to control the movement patterns of their knees and lower limbs - particularly in high-demand tasks like jumping. The project will develop a new ASICS shoe that will be ‘field-tested’ during sporting activity with high ACL injury risk (netball) to evaluate ....Athletic footwear for reducing knee loads in girls and women. This project aims to develop a novel athletic shoe that can reduce harmful knee loads during sport in adolescent girls and young women. As girls reach puberty, they become less able to control the movement patterns of their knees and lower limbs - particularly in high-demand tasks like jumping. The project will develop a new ASICS shoe that will be ‘field-tested’ during sporting activity with high ACL injury risk (netball) to evaluate its effect on tibial shock (in-field surrogate measure of knee load) and player comfort compared to a conventional shoe. Expected outcomes include reduced healthcare costs associated with the treatment of serious knee injury, including surgical reconstruction and early-onset knee osteoarthritis.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE160100042
Funder
Australian Research Council
Funding Amount
$325,000.00
Summary
Multitasking effects on motor control in childhood through adolescence. This project aims to increase knowledge on the development of motor control and its cognitive determinants. The ability to perform cognitive and motor tasks simultaneously is a critical skill for daily living. From childhood to adolescence, and across a range of developmental disorders, simultaneous performance of cognitive and motor tasks represents a major challenge. Children with cognitive and motor coordination problems ....Multitasking effects on motor control in childhood through adolescence. This project aims to increase knowledge on the development of motor control and its cognitive determinants. The ability to perform cognitive and motor tasks simultaneously is a critical skill for daily living. From childhood to adolescence, and across a range of developmental disorders, simultaneous performance of cognitive and motor tasks represents a major challenge. Children with cognitive and motor coordination problems show increased inattention, hyperactivity, psychosocial difficulties and negative perceptions of self-worth. This project aims to investigate how the cognitive demands of balance control during walking changes from childhood to adolescence. The results may help to identify the mechanisms underlying childhood disorders associated with comorbid cognitive and motor impairments and provide strategies for earlier identification.Read moreRead less
Determining the neural mechanisms of visual stimuli and motor responses. This project aims to determine how we select actions to visual cues rapidly, unconsciously and automatically. Learning associations between visual stimuli and motor responses is part of normal development and continues throughout life. Rapid deployment of these actions is often critical for safety yet we have limited knowledge of how the human brain does this. This project will use neuroimaging tools to characterise the spa ....Determining the neural mechanisms of visual stimuli and motor responses. This project aims to determine how we select actions to visual cues rapidly, unconsciously and automatically. Learning associations between visual stimuli and motor responses is part of normal development and continues throughout life. Rapid deployment of these actions is often critical for safety yet we have limited knowledge of how the human brain does this. This project will use neuroimaging tools to characterise the spatial and temporal neural architecture underlying these processes and determine how the dorsal and ventral streams of visual processing, specialised for motor control and recognition respectively, interact in vision-based actions as these actions become learned.Outcomes will provide new frameworks for driving improvement in any domain in which goal-directed actions depend on the rapid processing of visual information, including human-machine interfaces for defence, economic development, education, health, science and technology.Read moreRead less
Learning control and computational models of human motor systems. With the aim of understanding how humans learn their body movements, this project addresses fundamental cross-disciplinary issues of learning control, robotics and computational models of human motor systems. The results will lead to improvements in smart industrial automation and the development of more effective rehabilitation stategies.
Motor Functioning In Young People With Attention Deficit Hyperactivity Disorder – Combined Type: A Three-dimensional Motion Analysis Study.
Funder
National Health and Medical Research Council
Funding Amount
$477,065.00
Summary
Attention deficit hyperactivity disorder –combined type (ADHD-CT) is a complex neuropsychiatric disorder with a progressively devastating impact on psychosocial development. The first objective of this study is to use 3D-motion analysis to ‘probe’ the underlying brain dysfunction which characterises ADHD-CT. The second objective of this study is to improve our understanding of the link between movement problems, and (a) injury proneness, and (b) social-communicative problems, in children with AD ....Attention deficit hyperactivity disorder –combined type (ADHD-CT) is a complex neuropsychiatric disorder with a progressively devastating impact on psychosocial development. The first objective of this study is to use 3D-motion analysis to ‘probe’ the underlying brain dysfunction which characterises ADHD-CT. The second objective of this study is to improve our understanding of the link between movement problems, and (a) injury proneness, and (b) social-communicative problems, in children with ADHD-CT.Read moreRead less
Motor control of the upper airway muscle genioglossus. This project aims to evaluate a recent proposal about the motor control of the upper airway muscle Genioglossus. The upper airway muscles, the most complex in the human body, are critical for breathing and speaking, but are not well understood. Genioglossus draws the base of the tongue forward to maintain airway patency. This project will study genioglossus during wakefulness and sleep in normal healthy individuals. It is anticipated that th ....Motor control of the upper airway muscle genioglossus. This project aims to evaluate a recent proposal about the motor control of the upper airway muscle Genioglossus. The upper airway muscles, the most complex in the human body, are critical for breathing and speaking, but are not well understood. Genioglossus draws the base of the tongue forward to maintain airway patency. This project will study genioglossus during wakefulness and sleep in normal healthy individuals. It is anticipated that the project will suggest improved avenues for treatment of sleep related respiratory disorders.Read moreRead less