Mosquito-borne alphaviruses such as Ross River and chikungunya viruses cause widespread epidemics and exert extreme pressure on the public health systems of affected regions. Alphaviruses spreads to joints and triggers a severe disease in those affected. There are no effective treatments or vaccines. The project will investigate virus-host interaction at the bite site. The outcome will be new knowledge to treat infection at the mosquito bite site to prevent joint disease.
Novel Insights Into The Pathobiology Of Alphavirus Infections
Funder
National Health and Medical Research Council
Funding Amount
$827,660.00
Summary
Infections with mosquito-borne viruses are increasing at an alarming rate worldwide. Ross River virus is endemic in parts of Australia, PNG and Pacific islands, while chikungunya virus is distributed globally and causes recurrent pandemics that involve millions of people. These viruses cause severe musculoskeletal disease for several months after infection. This project aims to establish how these viruses interact with the human host to cause disease and may provide a basis for new treatments.
New Insights Into Viral Inflammatory Disease Mechanisms And Approaches To Therapy
Funder
National Health and Medical Research Council
Funding Amount
$631,010.00
Summary
This fellowship aims to establish how viruses cause disease, including how they evade the immune response to persist and cause disease for prolonged periods. My vision is that knowing how the virus and the immune system interact to determine disease severity will assist in devising new treatments and prevention programs to lessen the impact of viral diseases in Australia and worldwide.
Understanding the mechanism of Wolbachia-mediated antiviral protection. Insects are involved in the transmission of many viral diseases of both plants and animals. A considerable number of these diseases have adverse effects for public health or cause large economic losses in agriculture. We were the first to discover that a common bacteria protects insects from virus infection. Knowledge of the mechanisms used by the bacteria to interfere with virus accumulation will facilitate novel strategies ....Understanding the mechanism of Wolbachia-mediated antiviral protection. Insects are involved in the transmission of many viral diseases of both plants and animals. A considerable number of these diseases have adverse effects for public health or cause large economic losses in agriculture. We were the first to discover that a common bacteria protects insects from virus infection. Knowledge of the mechanisms used by the bacteria to interfere with virus accumulation will facilitate novel strategies for control of virus disease. The findings of this project will enable Australian researchers and industry to design innovative approaches to control diseases that are transmitted by insects.Read moreRead less
Income insecurity in Australia: who is feeling the pinch and why? This project aims to measure and investigate the drivers of income insecurity in Australia. It will provide an evaluation of whether income growth is sufficient to compensate for any welfare loss due to higher income risk and the effectiveness of government taxes and transfers in alleviating income risks for different population sub-groups.
Investigation of key factors affecting the polarisation based diagnostics of power transformers. To avoid system wide power interruptions, major assets in the electricity network must be always operating satisfactorily. One of the key assets in the electricity network is the power transformer. Currently many transformers are over 50 years old and failure of a transformer may result in long interruptions in supply and the loss of millions of dollars in revenue. The ageing of transformers needs to ....Investigation of key factors affecting the polarisation based diagnostics of power transformers. To avoid system wide power interruptions, major assets in the electricity network must be always operating satisfactorily. One of the key assets in the electricity network is the power transformer. Currently many transformers are over 50 years old and failure of a transformer may result in long interruptions in supply and the loss of millions of dollars in revenue. The ageing of transformers needs to be properly monitored to avoid catastrophic failures. This project will provide an innovative solution for the better understanding of the ageing processes of transformers and help
managers make correct decisions for maintenance and replacement strategies.
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Sustainable operation of transformers with better understanding of technical and economic constraints. Transformer failure can be devastating to consumers and network service providers, costing from thousands to millions of dollars in transformer replacement and lost productivity. To avoid such catastrophic failures, the goal of this project will be to develop new methods that can maximise transformer usage and minimise cost before failure occurs.
Rapidly Locating Items in Distribution Networks with Process-Driven Nodes. Safety-critical product recalls are a major public health issue in Australia. Recent extortion attempts involving poisoning of chocolate bars, paracetamol tablets and biscuits have demonstrated the urgent need for improved ways of locating commercial products that have been released into the community. Existing product recall tools are effective only within regulated manufacturing and warehousing facilities. This project ....Rapidly Locating Items in Distribution Networks with Process-Driven Nodes. Safety-critical product recalls are a major public health issue in Australia. Recent extortion attempts involving poisoning of chocolate bars, paracetamol tablets and biscuits have demonstrated the urgent need for improved ways of locating commercial products that have been released into the community. Existing product recall tools are effective only within regulated manufacturing and warehousing facilities. This project will develop novel techniques for locating items in large-scale distribution networks driven by complex logistic processes. The outcomes of the project will make it easier to rapidly and accurately pinpoint product locations outside controlled facilities, thus contributing to both cost savings and public safety.Read moreRead less
Condition Assessment of Medium-Voltage XLPE-Insulated Cables Degraded by Water Treeing. In Australia degraded underground XLPE cables are causing disruption of electricity supplies and high community costs. There is no reliable non-invasive technique for prediction of cable condition to optimise cable replacement and refurbishment. In this project a large-scale experiment will be undertaken on 22 kV cables to ascertain the effectiveness of a new cable refurbishment technology. New techniques for ....Condition Assessment of Medium-Voltage XLPE-Insulated Cables Degraded by Water Treeing. In Australia degraded underground XLPE cables are causing disruption of electricity supplies and high community costs. There is no reliable non-invasive technique for prediction of cable condition to optimise cable replacement and refurbishment. In this project a large-scale experiment will be undertaken on 22 kV cables to ascertain the effectiveness of a new cable refurbishment technology. New techniques for assessment of cable condition will be developed using unique data from the ageing experiment and computer models of fundamental phenomena. Successful conclusions from this project will save the industry partner and other electricity distribution companies tens of millions of dollars.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0883074
Funder
Australian Research Council
Funding Amount
$600,000.00
Summary
Distributed Generation Evaluation Facility and Power Control. The development and demonstration of Distributed Energy Resource solutions will assist the deployment of greenhouse gas reduction strategies and of reliability improvements with particular benefits for rural and remote electricity supply. Small generation units can be the best solution for some reliability and voltage support issues in rural/remote networks. The research will show how these can be operated and the benefits achievable ....Distributed Generation Evaluation Facility and Power Control. The development and demonstration of Distributed Energy Resource solutions will assist the deployment of greenhouse gas reduction strategies and of reliability improvements with particular benefits for rural and remote electricity supply. Small generation units can be the best solution for some reliability and voltage support issues in rural/remote networks. The research will show how these can be operated and the benefits achievable for sources including renewables in a manner that is accessible to communities and with a rigorous set of test scenarios that will satisfy concerns from utilities. The flexible system nature is the significant development previously unavailable to researchers/developers.Read moreRead less