Mosquito-borne alphaviruses such as Ross River and chikungunya viruses cause widespread epidemics and exert extreme pressure on the public health systems of affected regions. Alphaviruses spreads to joints and triggers a severe disease in those affected. There are no effective treatments or vaccines. The project will investigate virus-host interaction at the bite site. The outcome will be new knowledge to treat infection at the mosquito bite site to prevent joint disease.
Novel Insights Into The Pathobiology Of Alphavirus Infections
Funder
National Health and Medical Research Council
Funding Amount
$827,660.00
Summary
Infections with mosquito-borne viruses are increasing at an alarming rate worldwide. Ross River virus is endemic in parts of Australia, PNG and Pacific islands, while chikungunya virus is distributed globally and causes recurrent pandemics that involve millions of people. These viruses cause severe musculoskeletal disease for several months after infection. This project aims to establish how these viruses interact with the human host to cause disease and may provide a basis for new treatments.
New Insights Into Viral Inflammatory Disease Mechanisms And Approaches To Therapy
Funder
National Health and Medical Research Council
Funding Amount
$631,010.00
Summary
This fellowship aims to establish how viruses cause disease, including how they evade the immune response to persist and cause disease for prolonged periods. My vision is that knowing how the virus and the immune system interact to determine disease severity will assist in devising new treatments and prevention programs to lessen the impact of viral diseases in Australia and worldwide.
Sustainable operation of transformers with better understanding of technical and economic constraints. Transformer failure can be devastating to consumers and network service providers, costing from thousands to millions of dollars in transformer replacement and lost productivity. To avoid such catastrophic failures, the goal of this project will be to develop new methods that can maximise transformer usage and minimise cost before failure occurs.
Innovative approaches to understanding and limiting the public health risks of Cryptosporidium and Giardia in animals in Australian catchments. Sophisticated molecular typing and modelling will be used to determine if chlorine-resistant parasites in animals in catchments are responsible for infection in humans. Improved catchment management and risk mitigation strategies will be developed during this project, which will make a substantial contribution to the provision of safe drinking water acro ....Innovative approaches to understanding and limiting the public health risks of Cryptosporidium and Giardia in animals in Australian catchments. Sophisticated molecular typing and modelling will be used to determine if chlorine-resistant parasites in animals in catchments are responsible for infection in humans. Improved catchment management and risk mitigation strategies will be developed during this project, which will make a substantial contribution to the provision of safe drinking water across Australia.Read moreRead less
Identifying genes that influence clinical course and susceptibility in multiple sclerosis. This project aims to identify the genetic basis of multiple sclerosis (MS), the most common neurologic disease in young Australian adults. MS urgently needs research to identify predisposition, aid early diagnosis and provide bona fide molecular targets for new therapies. This will benefit people with MS and those susceptible to it. Crucial new knowledge identified will benefit other major areas of MS rese ....Identifying genes that influence clinical course and susceptibility in multiple sclerosis. This project aims to identify the genetic basis of multiple sclerosis (MS), the most common neurologic disease in young Australian adults. MS urgently needs research to identify predisposition, aid early diagnosis and provide bona fide molecular targets for new therapies. This will benefit people with MS and those susceptible to it. Crucial new knowledge identified will benefit other major areas of MS research including epidemiology, immunology and neurobiology. Collaboration of 8 major Australian institutions is also important for this project and future studies. The team will have access to a new national MS GeneBank (platform) with samples from 2240 patients that should generate findings important to world-wide MS genetic knowledge.Read moreRead less
Talent Mismatch: Evidence from Australian Administrative Tax Records. The project aims to study the skill composition of the Australian workforce. Changes in the macroeconomic and technology environments make it hard to predict skill shortage. The project expects to develop macroeconomic models quantifying skill-mismatch of university graduates, identify sources of mismatch, highlight gender and generational differences, and estimate associated costs to Australia. The expected outcomes are to he ....Talent Mismatch: Evidence from Australian Administrative Tax Records. The project aims to study the skill composition of the Australian workforce. Changes in the macroeconomic and technology environments make it hard to predict skill shortage. The project expects to develop macroeconomic models quantifying skill-mismatch of university graduates, identify sources of mismatch, highlight gender and generational differences, and estimate associated costs to Australia. The expected outcomes are to help shape policy recommendations on the funding of tertiary education in a changing economic climate. This should provide significant benefits to Australians, as policies shaping the tertiary education system affect individual income and the aggregate economy by determining labour supply and taxpayers' financial burden.Read moreRead less
Ecology and transmission of tick-borne disease in Australia. Ecology and transmission of tick-borne disease in Australia. This project aims to determine the bacterial, protozoal and viral biodiversity in wildlife ticks and their native mammal hosts, and provide new information about the biology and transmission dynamics of these microorganisms and their potential to cause disease in wildlife, domesticated animals and humans. Anticipated outcomes are improved diagnostic tests and management proto ....Ecology and transmission of tick-borne disease in Australia. Ecology and transmission of tick-borne disease in Australia. This project aims to determine the bacterial, protozoal and viral biodiversity in wildlife ticks and their native mammal hosts, and provide new information about the biology and transmission dynamics of these microorganisms and their potential to cause disease in wildlife, domesticated animals and humans. Anticipated outcomes are improved diagnostic tests and management protocols for tick-borne disease in Australia.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0453426
Funder
Australian Research Council
Funding Amount
$235,000.00
Summary
Access for Australian Researchers to Advanced Neutron Beam Techniques. Neutron scattering is one of the most powerful and important investigative tools in the study of materials. Australia has only a low-flux neutron source, HIFAR, which provides no cold or hot neutrons. This excludes large, important areas of science, such as functional films, polymers, self-assembly systems, biological materials, colloids and emulsions, and real-time in-situ studies.
This application aims to continue Australi ....Access for Australian Researchers to Advanced Neutron Beam Techniques. Neutron scattering is one of the most powerful and important investigative tools in the study of materials. Australia has only a low-flux neutron source, HIFAR, which provides no cold or hot neutrons. This excludes large, important areas of science, such as functional films, polymers, self-assembly systems, biological materials, colloids and emulsions, and real-time in-situ studies.
This application aims to continue Australia's partnership with the world's most intense neutron source, ISIS in the UK, in order to sustain the considerable Australian scientific momentum which now relies on ISIS.
The outcomes will be new science that cannot be generated solely within Australia.
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Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0882725
Funder
Australian Research Council
Funding Amount
$1,000,000.00
Summary
Access for Australian Researchers to Advanced Neutron Beam Techniques. The major national benefit will be access, by peer review, to the 35 specialised instruments at the world's leading pulsed Neutron and Muon source, ISIS. This complements the access to the eight neutron instruments that will operate at the Australian Reactor OPAL. This will support (or enable) high quality research into areas as diverse as materials development, mineral processing and aspects of biological and medical scien ....Access for Australian Researchers to Advanced Neutron Beam Techniques. The major national benefit will be access, by peer review, to the 35 specialised instruments at the world's leading pulsed Neutron and Muon source, ISIS. This complements the access to the eight neutron instruments that will operate at the Australian Reactor OPAL. This will support (or enable) high quality research into areas as diverse as materials development, mineral processing and aspects of biological and medical science. It will facilitate international collaborations that are important for both research and post-graduate student training.Read moreRead less