Premature Mortality Post Fracture:A NSW Linked Data Study
Funder
National Health and Medical Research Council
Funding Amount
$391,012.00
Summary
Osteoporotic fractures are associated with increased morbidity and mortality. Anti-osteoporosis medications reduce re-fracture and possibly morality, yet osteoporosis is poorly treated. This study will link information from >260,000 people (45&Up study) with hospital admissions, medications and deaths to create the largest, detailed dataset of its kind. We will be able to determine cause of any fracture-associated mortality and the effect of medication to improve osteoporosis management.
Improving Outcomes In Osteoporosis And Bone Health
Funder
National Health and Medical Research Council
Funding Amount
$348,494.00
Summary
Osteoporotic fractures are a common and increasing problem as the population ages. They are associated with increased risk of re-fracture and early death yet most patients remain untreated. This proposal will identify which fracture patients are at highest risk of re-fracture and premature death (b) identify whether osteoporosis treatment decreases this risk and (c) increase osteoporosis awareness and treatment uptake by general practitioners with an integrated fracture risk prediction tool.
Osteoporosis is a common problem with increased premature mortality associated with hip and even more minor fractures. The cause of increased mortality is debated although osteoporosis treatment may decrease this risk. This study will be the first to examine survival of all subjects in NSW admitted for a fracture including cause for subsequent hospitalisation and treatment taken. This study will help define the cause of the mortality and the role of anti osteoporosis treatment on outcome.
Prediction Of Adverse Outcomes Following A Fragility Fracture
Funder
National Health and Medical Research Council
Funding Amount
$148,426.00
Summary
Individuals with an existing fracture are at increased risk of adverse outcomes such as re-fracture and premature mortality, but it is not clear why. We propose to evaluate risk factors, and prognostic models, for predicting the risk of adverse outcomes. We also propose to develop a quantitative risk-benefit framework for evaluating the clinical utility of such prognostic models and help ensure that therapies appropriately address real-life experience of osteoporotic patients.
Stress Hyperglycaemia And Mortality In Critical Illness: Defining The Association And Underlying Mechanisms
Funder
National Health and Medical Research Council
Funding Amount
$125,526.00
Summary
The relationship between high blood sugar levels (hyperglycaemia) and mortality in critically ill patients remains an area of controversy with conflicting results between studies. This PhD thesis will attempt to resolve this by firstly evaluating whether relative hyperglycaemia as measured using a novel new measure better predicts mortality outcome in such patients; and secondly, attempt to establish possible mechanisms which contributes to this.
The overall aim is to improve treatments and outcomes for people with osteoporosis. This will be achieved by better predicting those who are likely to fracture and subsequently those who do well post fracture from those who do poorly. Following an osteoporotic fracture there is an increased risk of re- fracture and of premature death. This research will define those risk factors for fracture, re-fracture and early death in a large group of men and women followed for over 20 years.
ADVANCE-ON: A Post-trial Observational Study Of ADVANCE
Funder
National Health and Medical Research Council
Funding Amount
$775,867.00
Summary
The ADVANCE (Action in Diabetes and Vascular Disease) study demonstrasted that intensive control of blood glucose only reduced kidney disease but that control of blood pressure reduced both cardiovascular and kidney disease. This 10-year post-trial follow up study will determine whether intensive control of blood glucose exerts cardiovascular benefits that emerge in the long term in patients with type 2 diabetes.
Insights Into The Acute Cerebral Lesion Of Childhood Diabetes And It's Neuropsychological Sequelae
Funder
National Health and Medical Research Council
Funding Amount
$416,000.00
Summary
Type 1 diabetes in childhood is a major cause of morbidity with an Australian prevalence of approximately 20 per 100,000 children under 15 years of age. The leading cause of death in type 1 diabetes in children and adolescents is diabetic ketoacidosis complicated by cerebral oedema (brain swelling), the origins of which remain unknown. This research is aimed at providing an insight into changes in the brain of children with diabetic ketoacidosis (DKA) and the relationship of these brain changes ....Type 1 diabetes in childhood is a major cause of morbidity with an Australian prevalence of approximately 20 per 100,000 children under 15 years of age. The leading cause of death in type 1 diabetes in children and adolescents is diabetic ketoacidosis complicated by cerebral oedema (brain swelling), the origins of which remain unknown. This research is aimed at providing an insight into changes in the brain of children with diabetic ketoacidosis (DKA) and the relationship of these brain changes to short and long term neuropsychological functioning. The major aim of this project is to provide an insight into brain changes of children with diabetic ketoacidosis (DKA) and the relationship of these brain changes to subseuqent brain function. This is a study where we will simply observe differences between newly diagnosed type 1 diabetic patients with no ktoacidosis, ketoacidosis or ketoacidosis with brain swelling over 6 months. We will measure brain function using various techniques includiung: magnetic resonance imaging (MRI), magnetic resonance spectroscopy (MRS), electrophysiology (EEG) and neuropsychological tests. The significance of this project is that it will provide insight into the brain impairment of diabetic patients with and without DKA, and with brain swelling in the context of DKA. By further clarifying the nature of brain impairment we will provide early intervention strategies to improve psychological development of the young patients with diabetes. In addition to this we hope to better understand the origins of brain swelling during DKA and design treatment protocols that will prevent this devastating complication.Read moreRead less