Electron, positron, and heavy-particle collisions with molecules. This project aims to develop a computational approach to collisions involving molecular targets with electrons, positrons and heavy particles. Recently, the approach to atomic collisions, the Convergent Close Coupling (CCC) method, has been extended and verified for positron, electron, and heavy particle collisions with the simplest molecular systems (molecular hydrogen and its ion). This project now aims to extend the CCC method ....Electron, positron, and heavy-particle collisions with molecules. This project aims to develop a computational approach to collisions involving molecular targets with electrons, positrons and heavy particles. Recently, the approach to atomic collisions, the Convergent Close Coupling (CCC) method, has been extended and verified for positron, electron, and heavy particle collisions with the simplest molecular systems (molecular hydrogen and its ion). This project now aims to extend the CCC method to study collisions with more complex molecules. Expected benefits include more accurate data for diagnostic tools such as Positron Emission Tomography, and potential advances in particle-based cancer therapy.Read moreRead less
How does timing affect mammalian brain development and evolution? This project aims to generate fundamental knowledge on the origin of diversity in mammalian brain circuits by studying development of marsupials and rodents. The expected outcome is to elucidate how differences in the timing, rate and sequence of development of gene expression, cell differentiation and circuit formation can relate to the origin of key evolutionary innovations in the mammalian brain. The significance of understandi ....How does timing affect mammalian brain development and evolution? This project aims to generate fundamental knowledge on the origin of diversity in mammalian brain circuits by studying development of marsupials and rodents. The expected outcome is to elucidate how differences in the timing, rate and sequence of development of gene expression, cell differentiation and circuit formation can relate to the origin of key evolutionary innovations in the mammalian brain. The significance of understanding the dynamics of developmental systems that shape complex brain traits includes establishing new developmental paradigms in evolutionary theory, generating new tools to investigate and manipulate brain gene expression in vivo, and the potential discovery of the causes of neurodevelopmental dysfunction.Read moreRead less
Multilevel selection and the integrity of mitochondrial DNA. This project aims to investigate the evolutionary conundrum of how and why organelles remain asexual. The widespread occurrence of sexual reproduction suggests that sex is beneficial to organisms. Yet we all carry an ancient genome that never had sex, the mitochondrial genome (mtDNA). Theory predicts that mtDNA should no longer exist, because without sex it accumulates deleterious mutations and cannot accumulate beneficial ones. Yet mt ....Multilevel selection and the integrity of mitochondrial DNA. This project aims to investigate the evolutionary conundrum of how and why organelles remain asexual. The widespread occurrence of sexual reproduction suggests that sex is beneficial to organisms. Yet we all carry an ancient genome that never had sex, the mitochondrial genome (mtDNA). Theory predicts that mtDNA should no longer exist, because without sex it accumulates deleterious mutations and cannot accumulate beneficial ones. Yet mtDNA does not suffer mutational meltdown and is shown to adapt. This project will explain how, proposing that the combination of two traits, uniparental inheritance and multiple genomes per cell, make up for the lack of sex. This project expects to provide an explanation for the evolutionary question of what keeps mitochondria healthy, important as mitochondria affect ageing and health.Read moreRead less
Improving the efficiency of CRISPR gene editing in cells. Human red blood cells are well-characterised and the globin gene locus is a model system for the study of gene regulation. Gene editing technologies and delivery tools are evolving rapidly and the globin gene locus is the perfect model for gene editing optimisation. This collaboration between UNSW Sydney and CSL aims to bring together our combined expertise and new technologies to develop an optimal platform for genetic modification in a ....Improving the efficiency of CRISPR gene editing in cells. Human red blood cells are well-characterised and the globin gene locus is a model system for the study of gene regulation. Gene editing technologies and delivery tools are evolving rapidly and the globin gene locus is the perfect model for gene editing optimisation. This collaboration between UNSW Sydney and CSL aims to bring together our combined expertise and new technologies to develop an optimal platform for genetic modification in a red blood cell line. Simultaneously, this project aims to generate fundamental insights into mechanisms of human gene regulation. The technological and biological outcomes of this project will be of benefit for future gene editing applications.Read moreRead less
Targeting Iron Piracy From Host Proteins By Neisseria And Haemophilus Spp. For The Development Of Novel Antimicrobials
Funder
National Health and Medical Research Council
Funding Amount
$645,205.00
Summary
The bacteria that cause the sexually transmitted infection gonorrhoea and meningococcal disease are a serious health concern. In order to cause disease, these bacteria must obtain the nutrient iron from our bodies. This proposed research will use cutting edge technologies to understand on a molecular level how these bacteria obtain iron during infection. It will then apply this knowledge to develop molecules that prevent these bacteria from obtaining iron, as a means of treating these diseases.
Tackling Antimicrobial Resistance In Neonatal Sepsis: Australia And Beyond
Funder
National Health and Medical Research Council
Funding Amount
$566,164.00
Summary
This project aims to establish clear data regarding the burden of antibiotic resistance in neonates in Australia & in our local South East Asian region. This will be achieved by establishing systematic data collection for infections with multi-resistant bacteria in Australian neonatal intensive care units, reviewing published literature regarding the cause of infections in South East Asian neonates, and continuing collaborative work to establish a new treatment regimen for neonatal sepsis.
Ion-atom collision data for fusion energy, hadron therapy and astrophysics. This project aims to combine experimental and theoretical efforts to generate accurate data required for the development and maintenance of fusion reactors, treatment planning in hadron therapy of cancerous tumours, and modelling astrophysical phenomena. Hadron therapy has been used successfully worldwide for over a decade with Australia’s first such facility, the Bragg Centre for Proton Therapy, currently under construc ....Ion-atom collision data for fusion energy, hadron therapy and astrophysics. This project aims to combine experimental and theoretical efforts to generate accurate data required for the development and maintenance of fusion reactors, treatment planning in hadron therapy of cancerous tumours, and modelling astrophysical phenomena. Hadron therapy has been used successfully worldwide for over a decade with Australia’s first such facility, the Bragg Centre for Proton Therapy, currently under construction. Fusion reactors are a source of abundant green energy. Immense progress is being made in their construction and underlying technology. Currently, there is an urgent demand for accurate data on ion-beam collisions with atoms and molecules for the aforementioned applications. This project intends to meet this demand.Read moreRead less
Electron-molecule collisions in fusion and astrophysical plasmas. This project will apply innovative methods developed in Australia to accurately model electron collisions with diatomic hydrides. It will generate new knowledge of the dynamics underlying fundamental chemical reactions, and bring international scientists together to study the influence of molecules in plasmas more accurately than ever before. Outcomes will include essential diagnostics for fusion reactors, methods for using the Ja ....Electron-molecule collisions in fusion and astrophysical plasmas. This project will apply innovative methods developed in Australia to accurately model electron collisions with diatomic hydrides. It will generate new knowledge of the dynamics underlying fundamental chemical reactions, and bring international scientists together to study the influence of molecules in plasmas more accurately than ever before. Outcomes will include essential diagnostics for fusion reactors, methods for using the James Webb Space Telescope to study astrophysical clouds, and strengthened ties between Australia and the global plasma physics community. The significant benefits will include accelerating the development of fusion technology as an alternative to fossil fuels, and furthering our understanding of stellar evolution.Read moreRead less
Antihydrogen formation. This project aims to advance fundamental understanding of collisions involving antimatter. The dominance of matter over antimatter in the Universe is one of the most intriguing questions of today’s science. Researchers at the European Organisation for Nuclear Research (CERN) are addressing this question by creating antihydrogen and studying its properties, including the gravitational behaviour. By trapping and cooling antihydrogen positive ions, ultra-cold antihydrogen at ....Antihydrogen formation. This project aims to advance fundamental understanding of collisions involving antimatter. The dominance of matter over antimatter in the Universe is one of the most intriguing questions of today’s science. Researchers at the European Organisation for Nuclear Research (CERN) are addressing this question by creating antihydrogen and studying its properties, including the gravitational behaviour. By trapping and cooling antihydrogen positive ions, ultra-cold antihydrogen atoms can be created and used in free fall experiments at CERN. The convergent close-coupling method and threshold theory will be used to provide the necessary theoretical guidance for the experimental antihydrogen positive ion formation via low-energy positronium-antiproton and positronium-antihydrogen collisions.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE240100176
Funder
Australian Research Council
Funding Amount
$349,987.00
Summary
Quantum studies of dissociative electron attachment to molecules. The ability to predict the outcomes of molecular collisions is a difficult, yet important, problem with many applications in science and industry. Recent work at Curtin University has led to the first complete solution of the electronic part of the scattering problem for collisions with the hydrogen molecule, a major breakthrough in the field. This project will build on this progress to accurately model the nuclear motion during c ....Quantum studies of dissociative electron attachment to molecules. The ability to predict the outcomes of molecular collisions is a difficult, yet important, problem with many applications in science and industry. Recent work at Curtin University has led to the first complete solution of the electronic part of the scattering problem for collisions with the hydrogen molecule, a major breakthrough in the field. This project will build on this progress to accurately model the nuclear motion during collisions, which will enable the first calculations of molecular dissociation processes without the use of approximations. The data which will be produced is highly sought-after in fusion energy and astrophysics applications.Read moreRead less