Molecular Epidemiology Of Infection In Aboriginal Communities
Funder
National Health and Medical Research Council
Funding Amount
$149,103.00
Summary
Destructive diseases of the gum tissue are known to be profoundly affected by modifying factors including systemic diseases such as diabetes, socio-economic conditions and the lack of effective control of microbial accumulation at the gum margin. This investigation will examine the hypothesis that a limited number of pathogenic bacterial strains, defined by quantitative molecular probe analysis, persist in or re-infect individuals to maintain a high disease burden in the presence of adverse modi ....Destructive diseases of the gum tissue are known to be profoundly affected by modifying factors including systemic diseases such as diabetes, socio-economic conditions and the lack of effective control of microbial accumulation at the gum margin. This investigation will examine the hypothesis that a limited number of pathogenic bacterial strains, defined by quantitative molecular probe analysis, persist in or re-infect individuals to maintain a high disease burden in the presence of adverse modifying factors that prevail in isolated, disadvantaged Aboriginal communities.Read moreRead less
Novel Nanoparticle Composites For Molecular Probes In Diagnostic Imaging
Funder
National Health and Medical Research Council
Funding Amount
$170,716.00
Summary
Isotope labelled protein probes, eg. antibodies, are a valuable imaging tool in investigating patient disease. Their biological specificity is their great strength, however, detection sensitivity often limits their use. A novel nanoparticle developed at ANU can increase this signal by a million-fold in comparison with conventional methods of labelling. This approach suits a range of probes and will accommodate many of the isotopes already used in patient diagnostics and therapy.