Investigating The Cellular Response To Iron-Depletion: The Trilogy Of ASK1, Thioredoxin And Ribonucleotide Reductase
Funder
National Health and Medical Research Council
Funding Amount
$552,572.00
Summary
Iron is crucial for many essential biological processes. Recently, we demonstrated that iron-depletion can affects important signalling pathways (e.g., JNK and p38) that play important roles in growth arrest and apoptosis. This study is designed to investigate the cellular and molecular effects of iron depletion which currently remains unclear. The research is crucial for understanding: (1) the effects of iron deficiency and (2) for understanding the effects of iron chelators that are used for t ....Iron is crucial for many essential biological processes. Recently, we demonstrated that iron-depletion can affects important signalling pathways (e.g., JNK and p38) that play important roles in growth arrest and apoptosis. This study is designed to investigate the cellular and molecular effects of iron depletion which currently remains unclear. The research is crucial for understanding: (1) the effects of iron deficiency and (2) for understanding the effects of iron chelators that are used for treating various diseases.Read moreRead less
Guarding and evolving the genome: interactions between DNA-repair enzymes and damaged DNA. The application of structural biology techniques to the area of DNA repair allows us to understand the full implications linking genes and proteins to the molecular mechanisms of diseases such as cancer and hereditory conditions. Studies in this highly internationally competitive area are already established in the Bond laboratory, which has recently relocated to Australia. The use of forward-thinking stru ....Guarding and evolving the genome: interactions between DNA-repair enzymes and damaged DNA. The application of structural biology techniques to the area of DNA repair allows us to understand the full implications linking genes and proteins to the molecular mechanisms of diseases such as cancer and hereditory conditions. Studies in this highly internationally competitive area are already established in the Bond laboratory, which has recently relocated to Australia. The use of forward-thinking structural biology approaches to solve difficult technical problems will foster collaborations within Australia and with leading laboratories abroad, providing excellent up-to-date research training for students and postdoctoral researchers.
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ARC Centre of Excellence - Centre for Antimatter-Matter Studies. While our world is made of matter, all particles have anti-particles and the most abundant is the positron, the electron's antiparticle. It is the "workshop" for most anti-matter studies, particularly for the characterization of materials, including gases, polymers, insulators, thin films and surfaces, as well as the development of new and novel, nano-structured materials. The ARC Centre of Excellence in Antimatter-Matter Studies ....ARC Centre of Excellence - Centre for Antimatter-Matter Studies. While our world is made of matter, all particles have anti-particles and the most abundant is the positron, the electron's antiparticle. It is the "workshop" for most anti-matter studies, particularly for the characterization of materials, including gases, polymers, insulators, thin films and surfaces, as well as the development of new and novel, nano-structured materials. The ARC Centre of Excellence in Antimatter-Matter Studies (CAMS) will bring together key Australian and international scientists to work in this emerging scientific field of antimatter-matter interactions. It will forge a unique and effective scientific team for state-of-the-art studies of the nano-world that underlies many everyday processes and new technologies.Read moreRead less
ARC Centre of Excellence in Plants for Space. ARC Centre of Excellence in Plants for Space. This Centre aims to create on-demand, zero-waste, high-efficiency plants and plant products to address grand challenges in sustainability for Space and on Earth. Significant advances in plant, food, and sensory science; process and systems engineering; law and policy; and psychology are expected to deliver transformative solutions for Space habitation – and create enhanced plant-derived food and bioresour ....ARC Centre of Excellence in Plants for Space. ARC Centre of Excellence in Plants for Space. This Centre aims to create on-demand, zero-waste, high-efficiency plants and plant products to address grand challenges in sustainability for Space and on Earth. Significant advances in plant, food, and sensory science; process and systems engineering; law and policy; and psychology are expected to deliver transformative solutions for Space habitation – and create enhanced plant-derived food and bioresources to capitalise upon emergent and rapidly expanding domestic and global markets. Anticipated outcomes include industry uptake of innovative plant forms, foods, technologies, and commodities; and an ambitious education and international co-ordination agenda to position Australia as a global leader in research supporting Space habitation.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE100100236
Funder
Australian Research Council
Funding Amount
$180,000.00
Summary
Facilities for spectroscopy and diffraction at high pressures. The provision of infrastructure for the study of novel materials under high pressures will enhance Australia's capability in creating new materials and in creating new devices that meet needs in communication, environment and medicine applications. The new facility will enable researchers to understand the response of structures to extreme pressures and will exploit the unique capabilities of the synchrotron light.
Discovery Early Career Researcher Award - Grant ID: DE160101101
Funder
Australian Research Council
Funding Amount
$348,741.00
Summary
Single-Molecule Circuitry for Nanoscale Electronic Devices. The aim of this project is to develop novel methods for forming robust single-molecule circuitry. The use of single molecules in electronics represents the next level of miniaturisation of electronic components, which would enable us to meet the expanding demands of modern technologies and to continue the downscaling trend in electronic devices. This project aims to address the requirements needed to translate single-molecule electronic ....Single-Molecule Circuitry for Nanoscale Electronic Devices. The aim of this project is to develop novel methods for forming robust single-molecule circuitry. The use of single molecules in electronics represents the next level of miniaturisation of electronic components, which would enable us to meet the expanding demands of modern technologies and to continue the downscaling trend in electronic devices. This project aims to address the requirements needed to translate single-molecule electronics from its current status as a fundamental tool to real-world applications. Key approaches will be the use of surface chemistry to develop new methods of wiring single molecules and the integration of robust single-molecule junctions with semiconducting electrodes. The expected project outcomes pave the way for single-molecule electronic and analytical devices.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0775637
Funder
Australian Research Council
Funding Amount
$450,000.00
Summary
An Australian Attosecond Science Facility. The laser facility requested here will provide Australian researchers with the ability to take snapshots of physical and biological processes at unprecedented time resolution. Such a facility will enable Australian researchers to remain competitive and continue to contribute significantly to scientific research on an international scale. The facility will provide excellent training for research higher degree students, preparing them for work in high-tec ....An Australian Attosecond Science Facility. The laser facility requested here will provide Australian researchers with the ability to take snapshots of physical and biological processes at unprecedented time resolution. Such a facility will enable Australian researchers to remain competitive and continue to contribute significantly to scientific research on an international scale. The facility will provide excellent training for research higher degree students, preparing them for work in high-tech industries based on cutting-edge discoveries in physics and biology.Read moreRead less
Industrial Transformation Training Centres - Grant ID: IC170100035
Funder
Australian Research Council
Funding Amount
$4,743,710.00
Summary
ARC Training Centre for Innovation in Biomedical Imaging Technology. The ARC Training Centre for Innovation in Biomedical Imaging Technology expects to train 20 industry-ready innovation scientists who will undertake industry-driven research in the development and application of novel diagnostics, therapeutics and theranostics. They will inform changes in regulatory policy that support industry growth. The Centre will build multidisciplinary links between researchers and within industry to devel ....ARC Training Centre for Innovation in Biomedical Imaging Technology. The ARC Training Centre for Innovation in Biomedical Imaging Technology expects to train 20 industry-ready innovation scientists who will undertake industry-driven research in the development and application of novel diagnostics, therapeutics and theranostics. They will inform changes in regulatory policy that support industry growth. The Centre will build multidisciplinary links between researchers and within industry to develop ‘smart’ probes and ‘smart’ scanning, harnessing the digital revolution for better, cost effective diagnostic imaging and improved health outcomes.Read moreRead less
Early Career Industry Fellowships - Grant ID: IE230100042
Funder
Australian Research Council
Funding Amount
$462,846.00
Summary
Developing a multimodal imaging pipeline for antisense technology. Antisense molecules represent a revolutionary drug discovery platform for life science, but to understand their distributions in cells and tissues is challenging. By integrating nanobiotechnology approaches, this project expects to develop and apply innovative imaging workflow to track antisense molecules in cells and tissues with nanoscale precision. Expected outcomes include new knowledge of the trafficking of these molecules a ....Developing a multimodal imaging pipeline for antisense technology. Antisense molecules represent a revolutionary drug discovery platform for life science, but to understand their distributions in cells and tissues is challenging. By integrating nanobiotechnology approaches, this project expects to develop and apply innovative imaging workflow to track antisense molecules in cells and tissues with nanoscale precision. Expected outcomes include new knowledge of the trafficking of these molecules across cells and tissues and refined imaging methods. This project should provide more strategic delivery of antisense molecules to specific cells and tissue, which will have significant downstream economic and social benefits to the Australian community. Read moreRead less