Organisation, expression and diversity of the sub-telomeric regions of the ancient eukaryote, Giardia duodenalis. We propose to extend our findings on the extreme plasticity of the structure and organisation of the sub-telomeric region of the complete genome of Giardia by more extensive chromosome walking, and comparison of different isolates. These regions are subject to gene conversion, transcriptional silencing, gene mobility, recombination, variable surface protein expression, subtelomeric i ....Organisation, expression and diversity of the sub-telomeric regions of the ancient eukaryote, Giardia duodenalis. We propose to extend our findings on the extreme plasticity of the structure and organisation of the sub-telomeric region of the complete genome of Giardia by more extensive chromosome walking, and comparison of different isolates. These regions are subject to gene conversion, transcriptional silencing, gene mobility, recombination, variable surface protein expression, subtelomeric instability and the insertion of transposable elements, a dynamic balance between structural conservation and rapid evolution. This is a rare opportunity to understand the forces at work in moulding eukaryotic sub-telomeric sequences because Giardia is not constrained by sexual homogenisation and the dynamic variability is retained.Read moreRead less
Kingdom switching microbial pathogens: the bioinformatics of mutation in the genomes of viruses and bacteria affecting crops, livestock and people. Some organisms that cause infectious diseases have moved between plants and vertebrates, either recently or repeatedly over evolutionary time. Switching between plants and vertebrates strongly influences the way these microbes mutate and evolve. We will search the genomic sequence databases for information about how the choice of host influences muta ....Kingdom switching microbial pathogens: the bioinformatics of mutation in the genomes of viruses and bacteria affecting crops, livestock and people. Some organisms that cause infectious diseases have moved between plants and vertebrates, either recently or repeatedly over evolutionary time. Switching between plants and vertebrates strongly influences the way these microbes mutate and evolve. We will search the genomic sequence databases for information about how the choice of host influences mutations in viral and bacterial genomes and model the evolutionary processes involved. This project will advance our understanding of the fine structure of microbial genomes and the importance of selection pressures on genes. It will lead to better disease management strategies for humans, and for domestic crops and livestock.Read moreRead less
Seeing without eyes: the evolution of non-visual photoreceptors in vertebrates. Australia's underwater biodiversity is second to none with endemic species representing the earliest stages in vertebrate evolution, many of them relying heavily on vision for survival. Tracing the evolution of light detection and image formation will provide crucial information about the lifestyles of our vertebrate ancestors, the environmental selection pressures driving speciation and colour communication. Charact ....Seeing without eyes: the evolution of non-visual photoreceptors in vertebrates. Australia's underwater biodiversity is second to none with endemic species representing the earliest stages in vertebrate evolution, many of them relying heavily on vision for survival. Tracing the evolution of light detection and image formation will provide crucial information about the lifestyles of our vertebrate ancestors, the environmental selection pressures driving speciation and colour communication. Characterisation of optimal light environments and extra-ocular light detection will also help protect and manage endemic species in wild and captive environments. Read moreRead less
Visualizing spin-related properties of functional nanostructures (for spintronics). This project contributes to undergraduate, postgraduate and postdoctoral research and training to encourage the pursuit of excellence, with:
- increased depth of knowledge in interdisciplinary research,
- a scientific environment providing access to research not otherwise in Australia,
- experience in the design, construction and development of scientific instruments.
Possible applications include high-speed ....Visualizing spin-related properties of functional nanostructures (for spintronics). This project contributes to undergraduate, postgraduate and postdoctoral research and training to encourage the pursuit of excellence, with:
- increased depth of knowledge in interdisciplinary research,
- a scientific environment providing access to research not otherwise in Australia,
- experience in the design, construction and development of scientific instruments.
Possible applications include high-speed magnetic filters, sensors, quantum transistors and spin qubits for quantum computers. The technological aspects of our project's outcomes offer real prospects of local development. The development of spin-polarized electron spectroscopy has great potential for existing applications in the surface science industry.
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Structure of Exotic Neutron-Rich Nuclei Populated Using Novel Reaction Mechanisms. Over half of the nuclei believed to be stable to particle decay have not been studied due to the lack of available nuclear reactions. We have played a leading role in developing innovative techniques using incomplete-fusion and deep-inelastic reactions to access neutron-rich nuclei that were inaccessible prior to this work. This project aims to study new phenomena in exotic, neutron-rich nuclei, building on Aust ....Structure of Exotic Neutron-Rich Nuclei Populated Using Novel Reaction Mechanisms. Over half of the nuclei believed to be stable to particle decay have not been studied due to the lack of available nuclear reactions. We have played a leading role in developing innovative techniques using incomplete-fusion and deep-inelastic reactions to access neutron-rich nuclei that were inaccessible prior to this work. This project aims to study new phenomena in exotic, neutron-rich nuclei, building on Australia's existing investment in this area, and, through international scientific leadership, facilitating the access of Australian researchers to highly competitive overseas facilities.Read moreRead less