Adaptive Evolution of BRCA1 in Ancestral Mammals. This project investigates adaptive evolution of BRCA1 in the early radiation of mammals. We will test the hypothesis that the evolution of mammary glands and X chromosome inactivation has resulted in modification of the BRCA1 protein sequence as it aquired new roles in these processes. We will also investigate the importance of these changes inducing compensatory changes in other parts of the protein.
Taming the intruders: the domestication of Tigger transposable elements in mammals. It has become apparent that most of the DNA that makes us what we are is actually comprised of the remnants of invading parasitic DNA acquired over time. A continual battle exists between host which tries to silence or remove this DNA, and the parasite that tries to multiply and spread. We are currently investigating an intriguing aspect of this process that involves host genomes 'domesticating' parasitic DNA to ....Taming the intruders: the domestication of Tigger transposable elements in mammals. It has become apparent that most of the DNA that makes us what we are is actually comprised of the remnants of invading parasitic DNA acquired over time. A continual battle exists between host which tries to silence or remove this DNA, and the parasite that tries to multiply and spread. We are currently investigating an intriguing aspect of this process that involves host genomes 'domesticating' parasitic DNA to provide novel functions, thereby facilitating the evolution of specific characteristics within species.Read moreRead less
Understanding the evolution of the alternation of generations in the land plant life cycle. This project will investigate the genetic basis and evolution of the land plant life cycle, in which both haploid and diploid phases consist of complex multicellular bodies. The project's findings, which will be made using two model laboratory plants, will be applicable to all plants and will help understand important processes such as pollen and seed production.
Development of new and high precision noble gas techniques for dating Quaternary volcanic rocks and surfaces: a Thermochronology and Noble Gas Geochronology and Geochemistry Organisation initiative. This project will calibrate noble gas dating methods, providing powerful tools for dating young volcanic rocks, eroded or buried surfaces and glacier/ice retreat. This research has considerable social, national and economic benefits for research training, volcanic hazard assessment, landscape evoluti ....Development of new and high precision noble gas techniques for dating Quaternary volcanic rocks and surfaces: a Thermochronology and Noble Gas Geochronology and Geochemistry Organisation initiative. This project will calibrate noble gas dating methods, providing powerful tools for dating young volcanic rocks, eroded or buried surfaces and glacier/ice retreat. This research has considerable social, national and economic benefits for research training, volcanic hazard assessment, landscape evolution, paleoclimate change and mineral exploration.Read moreRead less
Australia's exceptional Palaeozoic fossil fishes, and a Gondwana origin for land vertebrates. The 370 million-year-old Gogo deposit in WA has produced the World's best-preserved fossil fishes of Devonian age. New discoveries of related forms in eastern and central Australia document the deep history of Australia's unique vertebrate fauna, and provide new evidence on the evolution of the first jaws and limbs in vertebrates. They indicate that the first land animals may have evolved on the Austral ....Australia's exceptional Palaeozoic fossil fishes, and a Gondwana origin for land vertebrates. The 370 million-year-old Gogo deposit in WA has produced the World's best-preserved fossil fishes of Devonian age. New discoveries of related forms in eastern and central Australia document the deep history of Australia's unique vertebrate fauna, and provide new evidence on the evolution of the first jaws and limbs in vertebrates. They indicate that the first land animals may have evolved on the Australian landmass. These remarkably preserved, information-rich skulls and braincases of some of the oldest known vertebrate fossils provide unique data on early evolution of the head and brain; they are held in national collections as a significant contribution to both National and World Heritage.Read moreRead less
Tolerance of temperature extremes under drought: linking physiological processes with morphological constraints on leaf function. Freezing temperatures affect over 70% of Australia. Each year frosts cause substantial damage to agriculture and forestry. We will examine how decrease in hydraulic conduit diameter increases freeze tolerance in native woody species and quantify impacts of this tolerance on productivity of leaves. The results have application in managing temperate woody vegetation un ....Tolerance of temperature extremes under drought: linking physiological processes with morphological constraints on leaf function. Freezing temperatures affect over 70% of Australia. Each year frosts cause substantial damage to agriculture and forestry. We will examine how decrease in hydraulic conduit diameter increases freeze tolerance in native woody species and quantify impacts of this tolerance on productivity of leaves. The results have application in managing temperate woody vegetation under current and future climate scenarios. By improving understanding of the behaviour of water in leaves during freezing, we will contribute to improved models of physical stresses and strains in biological tissues during freezing, which find application in cryo-storage of biological materials important in agriculture, medicine, and conservation.Read moreRead less
Atomic scale imaging with high coherence electrons and ions. This project aims to combine a cold atom electron-ion source with a commercial microscope column for atomic-scale imaging in biosciences and materials science. Nanoscale imaging with electron and ion microscopy are tools for investigating the world at the atomic scale, underpinning development in modern technologies from semiconductor devices to medical treatments. This project will use ideas from laser cooling of atoms and atom optics ....Atomic scale imaging with high coherence electrons and ions. This project aims to combine a cold atom electron-ion source with a commercial microscope column for atomic-scale imaging in biosciences and materials science. Nanoscale imaging with electron and ion microscopy are tools for investigating the world at the atomic scale, underpinning development in modern technologies from semiconductor devices to medical treatments. This project will use ideas from laser cooling of atoms and atom optics to achieve new imaging modalities for time-lapse imaging of fundamental processes at the nano-scale. It will allow increasingly small scale resolution of fundamental processes at the nano-scale.Read moreRead less
Calibrating Cosmology: The Near-Field Approach to Galaxy Formation. Understanding the formation and evolution of structure in the early Universe continues to elude astronomers. Studying these earliest epochs is the driver for billion-dollar investments like the Next Generation Space Telescope and the Square Kilometre Array (with Australia as a primary partner). Our complementary 'near-field cosmology' project is unique, blending strengths in computational cosmology, stellar nucleosynthesis, and ....Calibrating Cosmology: The Near-Field Approach to Galaxy Formation. Understanding the formation and evolution of structure in the early Universe continues to elude astronomers. Studying these earliest epochs is the driver for billion-dollar investments like the Next Generation Space Telescope and the Square Kilometre Array (with Australia as a primary partner). Our complementary 'near-field cosmology' project is unique, blending strengths in computational cosmology, stellar nucleosynthesis, and optical astronomy, to 'deconstruct' the formation history of the one galaxy with detailed chemical and kinematical information - our own Milky Way. Combining theory and observation, cosmology and nucleosynthesis, we will produce the template for galaxy formation, providing the anchor for 'far-field' cosmology.Read moreRead less
Auger, Quantum Electro-Dynamics, Axions and New Technology. New technology developed by Australia, Sweden and the United States will be applied to major questions about the application of relativistic quantum mechanics to atomic structure and dynamics and spectroscopy, especially including critical issues in quantum electro-dynamics for atomic physics and applications. Discrepancies in quantum electro-dynamics have dominated international debate for decades, with claimed explanations annually fa ....Auger, Quantum Electro-Dynamics, Axions and New Technology. New technology developed by Australia, Sweden and the United States will be applied to major questions about the application of relativistic quantum mechanics to atomic structure and dynamics and spectroscopy, especially including critical issues in quantum electro-dynamics for atomic physics and applications. Discrepancies in quantum electro-dynamics have dominated international debate for decades, with claimed explanations annually failing to reveal the cause. Also a pattern of discrepancies has been seen at X-ray energies in first row metal atoms, with a similar sign and magnitude. A combined experimental an theoretical investigation will aim to reveal new light on these anomalies and serve to develop our understanding of the universe.Read moreRead less
The Epigenetics of Sex in the Dragon. Genetic codes do not directly translate to phenotypes -- environment acts through epigenetics to modify development. We use advanced molecular techniques to examine how epigenetics responds to temperature to reverse sex in our novel animal model, the dragon lizard. How does the cell sense temperature? Once the extrinsic signal is captured, how does it influence chromatin modification to release or suppress key genes in the sex differentiation pathway? Which ....The Epigenetics of Sex in the Dragon. Genetic codes do not directly translate to phenotypes -- environment acts through epigenetics to modify development. We use advanced molecular techniques to examine how epigenetics responds to temperature to reverse sex in our novel animal model, the dragon lizard. How does the cell sense temperature? Once the extrinsic signal is captured, how does it influence chromatin modification to release or suppress key genes in the sex differentiation pathway? Which sex genes are targets? Epigenetic enzymes are astonishingly conserved, providing exciting opportunities to draw from human systems to unravel novel signatures of temperature-induced sex switching in reptiles. This project will advance knowledge of developmental programming generally.Read moreRead less