Blood Biomarker Discovery For The Diagnosis Of Alzheimers Disease
Funder
National Health and Medical Research Council
Funding Amount
$292,639.00
Summary
Alzheimer's disease (AD) currently affects approximately 24 million people world wide, with >200,000 people within Australia currently affected, by 2050 an estimated 730,000+ people will be affected. The discovery of blood based biomarkers for AD will enable earlier diagnosis of AD, allowing early preventative treatments to be given. Thus, reduce the rate of disease progression and the cost of care and, gain significant improvement in the quality of life for the patients and their families.
Targeting The Metastasis Suppressor NDRG1 For The Treatment Of Pancreatic Cancer.
Funder
National Health and Medical Research Council
Funding Amount
$327,142.00
Summary
We will investigate NDRG1, a novel molecular target that has been demonstrated to inhibit the progression of numerous cancers. We aim to better understand the underlying functions of NDRG1 in pancreatic cancer and how we can potentially target this gene with novel therapeutics being developed in our laboratory. We hope that this new approach will lead to more promising treatment options and a better outcome for those suffering from pancreatic cancer.
Studying The Function And Mechanism Of Histone ADP-ribosylation; (ii) Lipo-peptide--protein Vaccine Development
Funder
National Health and Medical Research Council
Funding Amount
$496,076.00
Summary
(i) Histones, which act as DNA supports, are subject to modifications, which may be associated with disease (e.g. cancers). A better understanding of these modifications will provide access to new medicines (ii) The production of new vaccines requires new vaccine development tools. We propose to use fats to produce vaccines which can be delivered via the mouth or nose rather than by injection.
Metabolic And Hormonal Pathways In Gynecological Cancer - Epidemiological Studies Of Risk And Survival
Funder
National Health and Medical Research Council
Funding Amount
$288,275.00
Summary
Metabolic and hormonal factors probably play a role in a womans chance of developing and surviving gynecological cancer, but the exact mechanisms are unclear. This project will use questionnaire information, blood and tumour samples of over 5,000 Australian women to examine the mechanisms leading to cancer development and survival among women with uterine and ovarian cancer, the two commonest female reproductive cancers. Results will help plan primary prevention strategies and care.
Identifying Novel Genome Instability Signatures In Cancer
Funder
National Health and Medical Research Council
Funding Amount
$320,891.00
Summary
Cancer is the single biggest clinical problem facing the world. An underlying hallmark of cancer is the accumulation of errors in the genetic information of a cell which arises through genomic instability. This research project aims to investigate novel molecules identified by our screening that function in response to genomic instability in cancer. This study is expected to define roles for each molecule in the maintenance of genomic stability and predict for patient diagnosis and outcome.
A One Health Approach To Assessing The Threat Of Clostridium Difficile To Australia’s Biosecurity: A Genomic Investigation Of Human, Animal And Environmental Isolates
Funder
National Health and Medical Research Council
Funding Amount
$318,768.00
Summary
Clostridium difficile is a bacterium that causes life-threatening diarrhoea in humans and animals and is a major public health issue in Australia. This project will study the genetic make-up of the bacterium and identify factors contributing to the emergence, evolution, and spread of C. difficile. This knowledge will be essential in guiding effective public health interventions and reducing deaths from C. difficile infection in humans and animals.