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The chemistry and biology of circular proteins. This project aims to develop plant-derived ultra-stable cyclic peptides for pharmaceutical and agricultural applications. The project will use innovative new methodologies for discovery, chemical synthesis and engineering of these molecules. It is expected that the project will contribute to high value biotechnology and agricultural industries in Australia. The proposed outcomes will include fundamental new knowledge on the biosynthesis of circular ....The chemistry and biology of circular proteins. This project aims to develop plant-derived ultra-stable cyclic peptides for pharmaceutical and agricultural applications. The project will use innovative new methodologies for discovery, chemical synthesis and engineering of these molecules. It is expected that the project will contribute to high value biotechnology and agricultural industries in Australia. The proposed outcomes will include fundamental new knowledge on the biosynthesis of circular proteins in plants, new approaches for their discovery and technologies for applying them as drug leads and agricultural products.Read moreRead less
Cell wall invertase regulates fruit and seed development through sugar signals, sugar transporters and plasmodesmal gating. This project seeks to understand the molecular and cellular events controlling carbohydrate allocation in fruit and seed by focusing the coupling between sugar metabolism and transport using tomato as a model. The information generated may provide technological opportunities to improve fruit and seed development hence, crop yield.
Mechanisms regulating plant cell expansion: assessing the role of aquaporins and sugar signalling. This project seeks to understand the role of water channel genes in controlling water flow into expanding plant cells by using cotton fibre as a model cell. Water flow plays critical roles in plant growth, hence yield. The information generated may provide technological opportunities for improving water flow and utilization, hence, crop yield.
Identifying novel salinity tolerance mechanisms by spatial and temporal analysis of lipids in barley. Agrifood production faces the dual challenges of an increasing world population and the threats of abiotic stresses arising from climate change and the erosion of arable land. Cereals, the major food crops, are poorly adapted to tolerate most abiotic stresses, including salinity. This project applies new technologies investigating spatial and temporal biochemical mechanisms a model cereal, Horde ....Identifying novel salinity tolerance mechanisms by spatial and temporal analysis of lipids in barley. Agrifood production faces the dual challenges of an increasing world population and the threats of abiotic stresses arising from climate change and the erosion of arable land. Cereals, the major food crops, are poorly adapted to tolerate most abiotic stresses, including salinity. This project applies new technologies investigating spatial and temporal biochemical mechanisms a model cereal, Hordeum vulgare (barley), utilises to adapt and tolerate salinity. The aims are to investigate the role of specifically plasma membrane lipids modulating either signalling pathways or membrane fluidity that impacts on adaptation during salinity. The results will provide new leads for the development of cereal germplasm with increased salt tolerance.Read moreRead less
Discovering the activity of novel CLE peptide hormones that regulate legume nodulation. This project aims to functionally characterise novel peptide hormones that regulate the number of nitrogen-fixing root nodules that legumes form. Findings will enhance the current nodulation model and could help to alleviate our reliance on expensive, often polluting, nitrogen-fertilisers by helping to optimise the nodulation process in agriculture.
Discovery of the systemic regulator of legume nodulation. This project aims to discover the novel, shoot-derived factor that legumes produce to regulate the number of nitrogen-fixing root nodules they form. Outcomes will enhance the current nodulation model and could help optimise the process in agriculture, which would help alleviate current reliance on nitrogen-fertilisers that are expensive and pollute.
Functional characterisation of the necrotrophic effector proteins Tox1 and Tox3 from the wheat pathogen Stagonospora nodorum. Fungal pathogens cost the Australian agricultural industry over one billion dollars per year. This project will build upon recent key advances to provide a fundamental basis on how fungal pathogens cause disease. The results from this study will promote future advances in disease management with the aim of securing Australian wheat supplies.
Isolation and functional characterisation of a pathogen meta effector able to inhibit detection of multiple disease effectors by resistant plants. The rust fungi are a major economic threat to crop production in Australia. This project will investigate the molecular mechanism used by a rust fungus to prevent detection of multiple disease-inducing proteins by resistant plants and generate knowledge that will lead to the development of new and more effective disease control strategies.
Resolving the steps in the evolution of C4 photosynthesis. This project aims to identify the molecular mechanisms responsible for the evolution of grasses using the C4 biochemical pathway that enables plants to survive in hot, dry, high-light environments. The endemic Australian subtribe Neurachninae is the only known grass group that contains C4 species, species using the ancestral C3 pathway, as well as species using pathways intermediate to C3 and C4. Through a comparative approach employing ....Resolving the steps in the evolution of C4 photosynthesis. This project aims to identify the molecular mechanisms responsible for the evolution of grasses using the C4 biochemical pathway that enables plants to survive in hot, dry, high-light environments. The endemic Australian subtribe Neurachninae is the only known grass group that contains C4 species, species using the ancestral C3 pathway, as well as species using pathways intermediate to C3 and C4. Through a comparative approach employing high-throughput sequencing technologies, it is expected that the molecular changes underlying the transition from C3 to C4 will be identified. These results should define what is required to engineer plant varieties with increased yield and the ability to withstand climate change effects.Read moreRead less
Finding the missing links in salt and water transport in plants. Grain crops and horticultural plants use proteins called aquaporins to move water across cell membranes, but a group of these proteins can also transport some important nutrient ions as well as toxic sodium ions. This project aims to reveal the molecular pathways that regulate water and ion transport via aquaporins using advanced techniques in biophysics and molecular biology. These results will provide novel insights into how plan ....Finding the missing links in salt and water transport in plants. Grain crops and horticultural plants use proteins called aquaporins to move water across cell membranes, but a group of these proteins can also transport some important nutrient ions as well as toxic sodium ions. This project aims to reveal the molecular pathways that regulate water and ion transport via aquaporins using advanced techniques in biophysics and molecular biology. These results will provide novel insights into how plants coordinate and adapt to changing water and salt conditions, addressing a missing link in how ions and water move in and out of plant vacuoles. Benefits include an expanded, innovative range of targets for plant breeding programs to improve plant productivity in our changing climate.Read moreRead less