Dynamic evolution of mutation rates: causes and impacts on genomic analysis. This project aims to illuminate the role of variation in mutation rate in driving evolutionary change. Mutation rate is a core parameter in evolutionary analyses in essential applications including epidemiology, conservation and medicine, yet remains a “black box” given arbitrary universal values. This project will take a whole-of-biodiversity approach to understanding the forces shaping mutation rate, impact on evoluti ....Dynamic evolution of mutation rates: causes and impacts on genomic analysis. This project aims to illuminate the role of variation in mutation rate in driving evolutionary change. Mutation rate is a core parameter in evolutionary analyses in essential applications including epidemiology, conservation and medicine, yet remains a “black box” given arbitrary universal values. This project will take a whole-of-biodiversity approach to understanding the forces shaping mutation rate, impact on evolution of biodiversity and effect on accuracy and precision of phylogenetic analyses. Using Australian case studies, the expected outcome of this project will be a greater understanding variation in mutation rate between species, providing significant benefits in developing more sophisticated and reliable phylogenetic analyses.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE230100003
Funder
Australian Research Council
Funding Amount
$387,373.00
Summary
The evolution of venom and its role in shaping biodiversity. This project aims to study how venom, nature's most powerful weapon, evolves and shapes biodiversity. Using the iconic Australian and New Guinean venomous snakes as a model, this project expects to develop a novel approach to profile venom composition from museum specimens, test competing hypotheses on the evolution of venoms, and test for the association between the evolution of venoms and the evolution of diversity in species richnes ....The evolution of venom and its role in shaping biodiversity. This project aims to study how venom, nature's most powerful weapon, evolves and shapes biodiversity. Using the iconic Australian and New Guinean venomous snakes as a model, this project expects to develop a novel approach to profile venom composition from museum specimens, test competing hypotheses on the evolution of venoms, and test for the association between the evolution of venoms and the evolution of diversity in species richness and morphology. Expected outcomes include the largest venom database for any animal group and a better understanding of how venoms evolve and what role they play in earth’s biodiversity. The generated venom data has potential to be used in future studies to aid in the development of anti-venoms and drugs.Read moreRead less
Evolving rates: foundations for the next generation of molecular clocks. This project aims to investigate the causes and consequences of variation in rate of DNA sequence evolution across three kingdoms of life. Dates estimated from DNA sequences have a wide range of applications, including evolutionary biology, conservation prioritisation and epidemiology. These methods rely on accurate rate estimates, but current models lack information about the biological drivers of rates of genomic change. ....Evolving rates: foundations for the next generation of molecular clocks. This project aims to investigate the causes and consequences of variation in rate of DNA sequence evolution across three kingdoms of life. Dates estimated from DNA sequences have a wide range of applications, including evolutionary biology, conservation prioritisation and epidemiology. These methods rely on accurate rate estimates, but current models lack information about the biological drivers of rates of genomic change. This project will test reliability of current methods, identify potentially misleading estimates of disease origin or conservation priorities, and develop new approaches with empirically-informed models of rate change.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE190100491
Funder
Australian Research Council
Funding Amount
$418,386.00
Summary
Linking genomic changes to the generation of biodiversity. This project aims to provide a suite of theories, methods and software to enhance our understanding on how the generation of variation at molecular level is linked to the generation of species richness at lineage level. This new approach tests various ways that molecular changes are manifested as patterns of diversification, as revealed by genomic data analysed at the lineage level in phylogenetic studies. Expected outcomes of this proje ....Linking genomic changes to the generation of biodiversity. This project aims to provide a suite of theories, methods and software to enhance our understanding on how the generation of variation at molecular level is linked to the generation of species richness at lineage level. This new approach tests various ways that molecular changes are manifested as patterns of diversification, as revealed by genomic data analysed at the lineage level in phylogenetic studies. Expected outcomes of this project add to a growing body of evolutionary theory and provide practical phylogenetic tools for future analyses. These should benefit Australia by improving our understanding on the formation of Australia’s biodiversity hotspots.Read moreRead less
Shedding Light on the Proton Radius Puzzle with Ultracold Helium. This project aims to shed light on an outstanding discrepancy in physics known as the proton radius puzzle, first seen in hydrogen but now being studied in helium. Capitalising on existing international collaboration between experiment and theory to exploit the advantages of ultracold helium, this project aims to determine the isotopic nuclear charge radius difference with unprecedented precision, using our state-of-the-art quantu ....Shedding Light on the Proton Radius Puzzle with Ultracold Helium. This project aims to shed light on an outstanding discrepancy in physics known as the proton radius puzzle, first seen in hydrogen but now being studied in helium. Capitalising on existing international collaboration between experiment and theory to exploit the advantages of ultracold helium, this project aims to determine the isotopic nuclear charge radius difference with unprecedented precision, using our state-of-the-art quantum electrodynamic theory. This will not only answer fundamental questions about helium atomic structure, but may also reveal new physics beyond the current Standard Model. The validation of atomic structure theory should provide benefits in applications including the realisation of more accurate atomic clocks.Read moreRead less
Time-space resolved photoelectron emission to control molecular processes. This project aims to resolve simultaneously the timing and space localisation of photoelectron emission from atoms and molecules as a means for targeted breaking of molecular bonds. Existing techniques determine the timing and spatial characteristics of photoemission independently. The simultaneous time-space resolution will allow for the precise manipulation of photoelectrons by a sequence of phase-stabilised laser pulse ....Time-space resolved photoelectron emission to control molecular processes. This project aims to resolve simultaneously the timing and space localisation of photoelectron emission from atoms and molecules as a means for targeted breaking of molecular bonds. Existing techniques determine the timing and spatial characteristics of photoemission independently. The simultaneous time-space resolution will allow for the precise manipulation of photoelectrons by a sequence of phase-stabilised laser pulses, a technique known as coherent control. The benefit of this project will be the coherently controlled breaking of molecular bonds in oxide, carbonyl and hydrocarbon molecules. The outcome will be a significant step forward in driving complex photochemical reactions in industry.Read moreRead less
Atomic sensors for dark matter, rotation and magnetic fields. This project aims to develop ultra-high-performance sensors. The research will explore new methods for using the magnetic and optical properties of atomic gases to enable multi-parameter sensing without crosstalk between measurements. It is expected that techniques will be developed to allow simultaneous sensing of rotation and magnetic fields using devices that are compact, ultra-precise and energy efficient. It is also anticipated t ....Atomic sensors for dark matter, rotation and magnetic fields. This project aims to develop ultra-high-performance sensors. The research will explore new methods for using the magnetic and optical properties of atomic gases to enable multi-parameter sensing without crosstalk between measurements. It is expected that techniques will be developed to allow simultaneous sensing of rotation and magnetic fields using devices that are compact, ultra-precise and energy efficient. It is also anticipated that these new atomic sensors will support a global network looking for dark matter, which although never seen, is thought to make up 85% of the mass of the universe. The outcomes are expected to benefit medical science, geo-exploration, high-tech manufacturing, navigation and our understanding of the universe.Read moreRead less
Efficient phylogenetic methods that manage the curse of genomic complexity. This project aims to develop new methods and software to infer the evolutionary history of organisms using genomic data. These new phylogenomic methods need to take account of the complexity of evolutionary processes and/or patterns in time (along the evolutionary tree) and space (along the genome). This project is significant because these methods must merge mathematics and statistics with High-Performance Computing to ....Efficient phylogenetic methods that manage the curse of genomic complexity. This project aims to develop new methods and software to infer the evolutionary history of organisms using genomic data. These new phylogenomic methods need to take account of the complexity of evolutionary processes and/or patterns in time (along the evolutionary tree) and space (along the genome). This project is significant because these methods must merge mathematics and statistics with High-Performance Computing to handle the huge quantities of genetic data and the complexity of evolution itself. An important expected outcome of this project will be the development and release of freely-available software that incorporates these new methods. This project expects to benefit scientists who need to infer phylogenies from genomic data. Read moreRead less
Inequality, Prosperity and the Australian Welfare State. This project aims to clarify contested understandings of Australian inequality and the role of economic and social policies in addressing policy challenges going forward. The objective of the project is to generate significantly improved knowledge of inequality in Australia using innovative approaches of data splicing, decomposition, simulation and backcasting to fill research gaps and resolve contested interpretations. We aim to provide a ....Inequality, Prosperity and the Australian Welfare State. This project aims to clarify contested understandings of Australian inequality and the role of economic and social policies in addressing policy challenges going forward. The objective of the project is to generate significantly improved knowledge of inequality in Australia using innovative approaches of data splicing, decomposition, simulation and backcasting to fill research gaps and resolve contested interpretations. We aim to provide a benchmark and robust framework against which policy development after the current crisis can be evaluated. This project aims to provide significant benefits, keeping Australia at the forefront of research on inequality and public policy, strengthening links between researchers and policy makers.
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Cold positron interactions with ultracold rubidium atoms. Antiparticles and antimatter have progressed from theory and science fiction to become an important and exciting area of pure and applied science. This fundamental atomic physics project aims to further study how antimatter and matter interact by providing the first comprehensive experimental results for the interaction of positrons (the electron anti-particle) with trapped rubidium atoms in an innovative combination of two cutting-edge ....Cold positron interactions with ultracold rubidium atoms. Antiparticles and antimatter have progressed from theory and science fiction to become an important and exciting area of pure and applied science. This fundamental atomic physics project aims to further study how antimatter and matter interact by providing the first comprehensive experimental results for the interaction of positrons (the electron anti-particle) with trapped rubidium atoms in an innovative combination of two cutting-edge atomic physics techniques. It aims to provide measurements of many fundamental interaction quantities and for collisions between matter and antimatter. This will look to test the latest quantum theoretical approaches and further our understanding of the uses of antimatter in medical and materials science.Read moreRead less