Improving Outcomes For Women Diagnosed With Mucinous Ovarian Cancer
Funder
National Health and Medical Research Council
Funding Amount
$598,238.00
Summary
Mucinous ovarian cancer (MOC) is different from other ovarian cancers but few studies have characterized the genetic changes specific to this subtype. It is often confused with metastases from other organs and does not respond well to standard ovarian cancer therapies. If MOC is more similar to mucinous cancers from other organs than other ovarian cancers, it may be better treated with chemotherapeutics that show success with other mucinous tumours.
Transcriptional Effectors Of Oncogenic ERK Signaling In Colorectal Cancer
Funder
National Health and Medical Research Council
Funding Amount
$820,776.00
Summary
This project aims to unravel how one of the most frequently deregulated molecular pathways in colorectal cancer controls the expression of genes required for these tumours to grow and spread. We expect this work to uncover novel therapeutic targets to effectively inactivate this pathway and biomarkers to select patients most likely to benefit from existing therapies.
Genetic Programs Orchestrated By AP-1 Transcription Factors In Colorectal Cancer Progression
Funder
National Health and Medical Research Council
Funding Amount
$599,941.00
Summary
Colorectal cancer (CRC) is the third most common cancer worldwide. About half of all patients diagnosed with the disease die as a result of its spread in the body. This project will investigate the role that a specific DNA-binding protein plays in orchestrating gene expression programs required for CRCs to spread. The research will provide new insights into underlying mechanisms of CRC progression as well as identify new therapeutic targets for aggressive forms of the disease.
Mechanistic Basis Of AP-1-regulated Gene Expression During Colorectal Cancer Progression
Funder
National Health and Medical Research Council
Funding Amount
$597,802.00
Summary
The spread of colorectal cancers in the body poses a major clinical problem for which current treatment options are inadequate. This project aims to unravel how a specific DNA-binding protein regulates the expression of genes involved in the spread of these cancers. The research is expected to provide a better mechanistic understanding of how disease progression occurs and to identify novel strategies to treat aggressive tumours.
How Does Fra-1 Regulate The Invasive Properties Of Tumour Cells?
Funder
National Health and Medical Research Council
Funding Amount
$468,119.00
Summary
Most cancer deaths occur when tumours spread and destroy vital body functions. The invasion of tumour cells into surrounding tissue is a critical step during the spread of cancer. This project aims to unravel the molecular mechanisms that control the ability of tumour cells to invade into surrounding tissue and subsequently spread to other sites in the body. We expect to identify potential targets to better diagnose and treat the spread of cancer.
Regulation Of Actin Polymerization During Malaria Parasite Invasion Of The Human Erythrocyte
Funder
National Health and Medical Research Council
Funding Amount
$318,147.00
Summary
Malaria parasites depend on successful invasion of red blood cells for their survival. Invasion is powered by a molecular motor based on two key proteins: actin and myosin. Non-specific drugs that inhibit parasite actin block invasion, demonstrating how important its regulation is to parasite success. This project will study several newly identified malaria actin-regulators, aiming to identify new drug targets that will block malaria actin function, stop motility and as such prevent disease.
Dynamics and correlations of many-body systems. The proposed program will greatly enhance Australian science through linking innovative
theoretical techniques with the successful ongoing Australian experimental program in atom
lasers, atom chip interferometry and ultra-cold fermions. Pioneering theoretical methods in
quantum phase-space are internationally recognized, and will be extended into new areas relevant
to Australia. These have fundamental significance to fields ranging from nanotec ....Dynamics and correlations of many-body systems. The proposed program will greatly enhance Australian science through linking innovative
theoretical techniques with the successful ongoing Australian experimental program in atom
lasers, atom chip interferometry and ultra-cold fermions. Pioneering theoretical methods in
quantum phase-space are internationally recognized, and will be extended into new areas relevant
to Australia. These have fundamental significance to fields ranging from nanotechnology to
astrophysics, as well as providing a route to improved atomic clocks and other instruments.
Combining these theoretical and computational methods from the physical sciences with biology
and genetics will provide future cross-disciplinary benefits to Australian biomedical science.Read moreRead less
Fermionic superfluidity in lower dimensional quantum gases. This project seeks to carry out cutting edge research on fermionic superfluidity using ultracold quantum gases. Through collaboration with one of the world's leading groups we will investigate the emerging issue of superfluidity in two-dimensional environments. This research will forge strong links with the European community and raise Australia's international profile in this rapidly growing field. Outstanding opportunities for youn ....Fermionic superfluidity in lower dimensional quantum gases. This project seeks to carry out cutting edge research on fermionic superfluidity using ultracold quantum gases. Through collaboration with one of the world's leading groups we will investigate the emerging issue of superfluidity in two-dimensional environments. This research will forge strong links with the European community and raise Australia's international profile in this rapidly growing field. Outstanding opportunities for young Australian scientists will arise through this collaboration and our findings may have implications for future superconducting technologies, based on the remarkable properties of fermionic superfluids.Read moreRead less
Life is swirl in flatland: two dimensional turbulence in a superfluid. The project will create two-dimensional turbulence in a superfluid gas of atoms in order to observe the predicted, but counter-intuitive, growth of ordered structure out of chaotic motion. The observation of such behaviour would support its mechanism as the explanation for phenomena such as giant eddies in ocean currents and the Great Red Spot of Jupiter.
Generation and Application of Ultracold Molecules. This project will extend the techniques of laser trapping and cooling of neutral atoms to produce ensembles of ultracold molecules, specifically Rb2. The starting point will be a cold sample of atoms, followed by the photoassociative formation of ultracold molecules. The ultracold molecules will be collected in a far-detuned optical dipole trap, and subsequently probed using femtosecond time-resolved spectroscopy. This unique combination of femt ....Generation and Application of Ultracold Molecules. This project will extend the techniques of laser trapping and cooling of neutral atoms to produce ensembles of ultracold molecules, specifically Rb2. The starting point will be a cold sample of atoms, followed by the photoassociative formation of ultracold molecules. The ultracold molecules will be collected in a far-detuned optical dipole trap, and subsequently probed using femtosecond time-resolved spectroscopy. This unique combination of femtosecond spectroscopy with ultraslow molecules will extend the study of chemical processes to an entirely new temperature regime, leading to a new understanding of the quantum nature of chemical reactions.Read moreRead less