Increased Airway Smooth Muscle Mass As An Independent Determinant Of Asthma Pathogenesis And Severity
Funder
National Health and Medical Research Council
Funding Amount
$409,966.00
Summary
Asthma is a major health burden to the community. The most common form of the disease is allergic asthma and it is thought that allergic inflammation drives associated airway abnormalities including increased airway smooth muscle (ASM) mass. This study tests a new hypothesis that airway abnormalities and allergy have separate origins but combine to produce allergic asthma, and it’s the individuals with the greatest amount of ASM who develop clinically severe asthma.
Mosquito-borne alphaviruses such as Ross River and chikungunya viruses cause widespread epidemics and exert extreme pressure on the public health systems of affected regions. Alphaviruses spreads to joints and triggers a severe disease in those affected. There are no effective treatments or vaccines. The project will investigate virus-host interaction at the bite site. The outcome will be new knowledge to treat infection at the mosquito bite site to prevent joint disease.
Novel Insights Into The Pathobiology Of Alphavirus Infections
Funder
National Health and Medical Research Council
Funding Amount
$827,660.00
Summary
Infections with mosquito-borne viruses are increasing at an alarming rate worldwide. Ross River virus is endemic in parts of Australia, PNG and Pacific islands, while chikungunya virus is distributed globally and causes recurrent pandemics that involve millions of people. These viruses cause severe musculoskeletal disease for several months after infection. This project aims to establish how these viruses interact with the human host to cause disease and may provide a basis for new treatments.
CCC method: new applications to electron scattering from atoms and molecules. Achievement of the stated aims will be of enormous benefit to industry
and laboratory research because at the present time no reliably accurate
models exist for the range of the required scattering parameters. The
modelling work will result in development of new software packages for
supercomputers and will provide training for research associates, PhD
and Honours students in an area where Australian theorists are ....CCC method: new applications to electron scattering from atoms and molecules. Achievement of the stated aims will be of enormous benefit to industry
and laboratory research because at the present time no reliably accurate
models exist for the range of the required scattering parameters. The
modelling work will result in development of new software packages for
supercomputers and will provide training for research associates, PhD
and Honours students in an area where Australian theorists are
preeminent.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0238631
Funder
Australian Research Council
Funding Amount
$200,000.00
Summary
Ultra High Resolution Electron Recycling Spectrometer. Electron collisions with atoms and molecules provide enormous versatility through the transfer of large amounts of angular momentum and the ability to excite dipole forbidden states. However a lack of energy resolution severely restricts the processes that can be studied.
We propose to construct a unique, ultra-high resolution, electron recycling spectrometer using a radical new design. State-of-the-art spectroscopic studies of ato ....Ultra High Resolution Electron Recycling Spectrometer. Electron collisions with atoms and molecules provide enormous versatility through the transfer of large amounts of angular momentum and the ability to excite dipole forbidden states. However a lack of energy resolution severely restricts the processes that can be studied.
We propose to construct a unique, ultra-high resolution, electron recycling spectrometer using a radical new design. State-of-the-art spectroscopic studies of atoms and molecules will be enabled, including the dynamics of near-threshold processes, the formation of transient states and the examination of processes such as rotational excitation and dissociative attachment in molecules - important in a number of gas-discharge based devices.
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A complete computational approach to electron-atom collisions. Our research contributes to multidisciplinary efforts to improve the efficiency and reduce the toxicity of lighting systems, which has far-reaching implications for environmental sustainability. It will also facilitate significant improvements in the accuracy of astrophysical and artificial plasma modelling, as well as providing insight into many processes fundamental to nanotechnology research. The research project will further enha ....A complete computational approach to electron-atom collisions. Our research contributes to multidisciplinary efforts to improve the efficiency and reduce the toxicity of lighting systems, which has far-reaching implications for environmental sustainability. It will also facilitate significant improvements in the accuracy of astrophysical and artificial plasma modelling, as well as providing insight into many processes fundamental to nanotechnology research. The research project will further enhance our reputation in an area where Australian theorists are preeminent, and the research training will produce PhD graduates with a high-level ability in numerical modelling using supercomputers. Such skills are essential in many defense, mining and technological applications of national priority.Read moreRead less
Electronic and atomic collision theory. Recently there has been rapid progress in the field of electronic and atomic collisions. Consequently, many new problems have emerged of interest to science and industry. The proposed collaboration will determine the most promising theoretical techniques for their solution. The problems include, for example, electron
collisions with noble gases, cesium and mercury, of interest to the laser, lighting and plasma processing industries. Time-dependent and tim ....Electronic and atomic collision theory. Recently there has been rapid progress in the field of electronic and atomic collisions. Consequently, many new problems have emerged of interest to science and industry. The proposed collaboration will determine the most promising theoretical techniques for their solution. The problems include, for example, electron
collisions with noble gases, cesium and mercury, of interest to the laser, lighting and plasma processing industries. Time-dependent and time independent, relativistic and non-relativistic approaches will be considered, thereby determining the direction of the field for the foreseeable future.Read moreRead less
Atomic Collision Theory. Collisions between atomic particles are ever-present in astrophysical and man-made plasmas. Their understanding is vital for both fundamental science and industrial applications. The project will develop underlying scattering theory to solve new and outstanding problems in the field. These range from the fundamental problems of electron- or proton-impact ionisation of hydrogen through to collisions involving targets of interest to astrophysics, fusion, X-ray lasers and t ....Atomic Collision Theory. Collisions between atomic particles are ever-present in astrophysical and man-made plasmas. Their understanding is vital for both fundamental science and industrial applications. The project will develop underlying scattering theory to solve new and outstanding problems in the field. These range from the fundamental problems of electron- or proton-impact ionisation of hydrogen through to collisions involving targets of interest to astrophysics, fusion, X-ray lasers and the lighting industry. The theory will also be extended to atom-surface interactions. The understanding of collisions between atomic particles and surfaces will support emerging fields of nanoscience and quantum computing.
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Complete calculation of positron- and electron-impact scattering of atoms. This research will facilitate a deeper understanding of the interaction of positrons (antimatter) with matter. These interactions are fundamental to Positron Emission Tomography used for medical imaging and Positron Annihilation Lifetime Spectroscopy used for characterisation of materials. This project will provide a fundamental theoretical description of positronium formation that combined with other multidisciplinary re ....Complete calculation of positron- and electron-impact scattering of atoms. This research will facilitate a deeper understanding of the interaction of positrons (antimatter) with matter. These interactions are fundamental to Positron Emission Tomography used for medical imaging and Positron Annihilation Lifetime Spectroscopy used for characterisation of materials. This project will provide a fundamental theoretical description of positronium formation that combined with other multidisciplinary research within the ARC Centre of Antimatter-Matter Studies will improve our knowledge of, and efficacy, of these techniques.Read moreRead less
Matter-antimatter interactions. Much of the light that we see is either due to or is influenced by collisions between particles on the atomic scale. The understanding of astronomical observations, the Sun, or our atmosphere is underpinned by the knowledge of atomic collisions. They are also critical in the development of fusion, lasers and lighting sources generally. Interactions with antimatter have additional applications in the medical and material sciences. For example, positron collisions w ....Matter-antimatter interactions. Much of the light that we see is either due to or is influenced by collisions between particles on the atomic scale. The understanding of astronomical observations, the Sun, or our atmosphere is underpinned by the knowledge of atomic collisions. They are also critical in the development of fusion, lasers and lighting sources generally. Interactions with antimatter have additional applications in the medical and material sciences. For example, positron collisions with matter are used in Positron Emission Tomography (PET) scans and in surface analysis.Read moreRead less