Understanding somatic mutation in plants: new methods, new software, new data. Somatic mutations accumulate as plants grow, affecting everything from short-term ecological interactions to long-term evolutionary dynamics. These mutations have important consequences for plant industry and conservation, but because they are so hard to measure almost nothing is known about them. This project aims to develop new methods and software to detect, analyse, and compare the genome-wide history of somatic m ....Understanding somatic mutation in plants: new methods, new software, new data. Somatic mutations accumulate as plants grow, affecting everything from short-term ecological interactions to long-term evolutionary dynamics. These mutations have important consequences for plant industry and conservation, but because they are so hard to measure almost nothing is known about them. This project aims to develop new methods and software to detect, analyse, and compare the genome-wide history of somatic mutation in individual plants, providing an unprecedented level of detail into an important but understudied source of biological variation. By applying these methods to an iconic experimental population, This project aims to provide the first insights into the genome-wide causes and consequences of somatic mutation in plants.Read moreRead less
Early evolution of the endomesoderm gene regulatory network. This project aims to unravel the endomesoderm gene network’s evolutionary history by identifying its conserved components’ target genes in the calcareous sponge Sycon. Little is known about the evolutionary origin of the developmental gene regulatory networks active in the development of all Eumetazoans (animals with nerves and digestive systems). Sponges are key models to study the transition from protists to eumetazoans, and gene exp ....Early evolution of the endomesoderm gene regulatory network. This project aims to unravel the endomesoderm gene network’s evolutionary history by identifying its conserved components’ target genes in the calcareous sponge Sycon. Little is known about the evolutionary origin of the developmental gene regulatory networks active in the development of all Eumetazoans (animals with nerves and digestive systems). Sponges are key models to study the transition from protists to eumetazoans, and gene expression data supports homology between sponge and eumetazoan tissues and body plans. This project could illuminate the evolutionary history of the animal body plan.Read moreRead less
The natural function and evolution of an essential parasite transporter. This project aims to resolve the natural function and evolution of a transporter essential to the survival of malaria and other parasites. Malaria and its sibling Apicomplexan parasites cause devastating diseases in humans and livestock across the world. Much remains to be understood about these parasites, and options for controlling them are diminishing. The project will interrogate the functions of the transporter protein ....The natural function and evolution of an essential parasite transporter. This project aims to resolve the natural function and evolution of a transporter essential to the survival of malaria and other parasites. Malaria and its sibling Apicomplexan parasites cause devastating diseases in humans and livestock across the world. Much remains to be understood about these parasites, and options for controlling them are diminishing. The project will interrogate the functions of the transporter proteins. The knowledge gained might help to combat Apicomplexan parasites by targeting these transporters’ native functions.Read moreRead less
Linking Stress Tolerance to Molecular Evolution of Grass Stomata. Salinity and drought are two detrimental environmental stresses, affecting agricultural productivity and ecosystem health in Australia and around the world. This project will focus on the evolutionary, physiological and molecular aspects of stomatal regulation between wheat, barley and their wild relatives for salinity and drought tolerance. This project will advance the scientific knowledge in the evolution of stomatal regulation ....Linking Stress Tolerance to Molecular Evolution of Grass Stomata. Salinity and drought are two detrimental environmental stresses, affecting agricultural productivity and ecosystem health in Australia and around the world. This project will focus on the evolutionary, physiological and molecular aspects of stomatal regulation between wheat, barley and their wild relatives for salinity and drought tolerance. This project will advance the scientific knowledge in the evolution of stomatal regulation in two staple crops wheat and barley. The project will also assist plant breeders with increasing crop salinity and drought tolerance for global food security.Read moreRead less
Exploring evolvability: its causes, consequences and practical applications in a changing environment. Are some species better able to adapt to a changing world? This question has been the focus of theoretical debate, but, as the scale of current environmental change becomes apparent, it has increasing practical importance, because it concerns the ability of biological communities to respond to climate change and the potential for agriculture to adapt a changing landscape. This project is the fi ....Exploring evolvability: its causes, consequences and practical applications in a changing environment. Are some species better able to adapt to a changing world? This question has been the focus of theoretical debate, but, as the scale of current environmental change becomes apparent, it has increasing practical importance, because it concerns the ability of biological communities to respond to climate change and the potential for agriculture to adapt a changing landscape. This project is the first of its kind, because it translates theoretical concepts into practical information needed for the development of salt-tolerant crops, new strategies for avoiding the growing problem of resistance in parasites, and new ways of detecting biological communities at risk of extinction and invasion. Read moreRead less
The role of auxin in root organ specification - from symbiont to parasite. Sustainable agriculture in a changing climate depends on strategies to maximise crop performance and to minimise crop losses due to parasites. This project aims to identify genes and molecular mechanisms that symbiotic and parasitic microbes, which affect major crop plants, use to alter plant growth in a beneficial or detrimental way.
The identification of Mycosphaerella graminicola effectors that promote pathogenicity on wheat. Fungal diseases are one of the greatest challenges to sustainable wheat production in the 21st century. Septoria tritici blotch is one such disease as it inflicts millions of tonnes in yield losses per annum. This project will identify the molecular basis of Septoria tritici blotch and assess its potential as an Australian biosecurity threat.
Microscopic many-body quantum dynamics: new approaches for fundamental science and applications. A new approach to create and validate a fundamental microscopic quantum theory of interactions of composite systems, like molecules and nuclei, by exploiting ideal features of nuclear reactions such as fusion will be developed. This will have broad impact in interdisciplinary areas from astrophysics and molecular reactions to future nanotechnologies.
Unlocking secrets of fertility restoration for hybrid breeding in crops. Hybrid varieties give higher and more stable yields than conventional lines, but a cost-effective system to make hybrid seed on a commercial scale is still missing for economically important crops like wheat or barley. By elucidating the mode of action of a new type of restorer gene plus exploiting ancient or exotic wheat and barley collections this project will reveal aspects of largely understudied mechanisms underlying f ....Unlocking secrets of fertility restoration for hybrid breeding in crops. Hybrid varieties give higher and more stable yields than conventional lines, but a cost-effective system to make hybrid seed on a commercial scale is still missing for economically important crops like wheat or barley. By elucidating the mode of action of a new type of restorer gene plus exploiting ancient or exotic wheat and barley collections this project will reveal aspects of largely understudied mechanisms underlying fertility restoration in wheat and barley. The expected outcomes of the proposed research have the potential to deliver new tools for hybrid seed production programs in wheat and barley. Higher and more stable yields from hybrids will ensure food security in the face of an uncertain climate and growing human population.Read moreRead less
Fusion Energy and the Physics of Burning Plasmas. The world faces a global energy crisis. Our standard of living, which is largely powered by base-load electricity supply, is unsustainable. Fusion power is a near zero greenhouse gas technology, which promises millions of years of base-load electricity, free from weapon proliferation. This promise has galvanised the international community to accelerate fusion development by committing to the next-step technology-enabling $16 billion experiment, ....Fusion Energy and the Physics of Burning Plasmas. The world faces a global energy crisis. Our standard of living, which is largely powered by base-load electricity supply, is unsustainable. Fusion power is a near zero greenhouse gas technology, which promises millions of years of base-load electricity, free from weapon proliferation. This promise has galvanised the international community to accelerate fusion development by committing to the next-step technology-enabling $16 billion experiment, International Thermonuclear Experimental Reactor (ITER). In anticipation of ITER, this fellowship will foster growth of Australian fusion research, and address a grand science challenge facing ITER: how do we maintain burn in the face of potentially damaging plasma instabilities? The answer will affect both ITER and the viability of fusion power.Read moreRead less