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Modelling TRPV4 Skeletal Disorders Using Human IPSCs
Funder
National Health and Medical Research Council
Funding Amount
$1,171,187.00
Summary
Inherited skeletal disorders are a significant disease burden. Many gene mutations have been defined but we only have limited understanding about how they cause the disease. We will use patient skin cells and new in vitro re-programing technology to induce them to form cartilage cells to produce “disease in a dish” models of human skeletal disorders. These models will allow us to answer questions about how specific mutations cause disease and identify potential therapies
Discovery And Development Of Better Pain Treatments
Funder
National Health and Medical Research Council
Funding Amount
$9,613,850.00
Summary
Many forms of pain remain poorly treated, leading to significant quality of life and economic losses. This Program grant will discover and characterise new peptides from cone snails and spiders that modulate specific channels in nerves that are critical to the transmission of pain signals to the brain. Using advanced chemical and structural approaches, promising leads will be optimised for potency and stability and evaluated in disease and pathway-specific models of pain to establish their clini ....Many forms of pain remain poorly treated, leading to significant quality of life and economic losses. This Program grant will discover and characterise new peptides from cone snails and spiders that modulate specific channels in nerves that are critical to the transmission of pain signals to the brain. Using advanced chemical and structural approaches, promising leads will be optimised for potency and stability and evaluated in disease and pathway-specific models of pain to establish their clinical potential.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE170100016
Funder
Australian Research Council
Funding Amount
$850,000.00
Summary
A collaborative electron microscopy network for structural biology. This project aims to establish a high-throughput pipeline to determine the near-atomic-resolution structure of proteins by cryo-electron microscopy (cryo-EM). Over the past five years, cryo-EM has improved the study of biological macromolecules at near-atomic resolution. This project will use two automated electron microscopes and a Titan Krios microscope to build a world-competitive integrated cryo-EM network for structural bio ....A collaborative electron microscopy network for structural biology. This project aims to establish a high-throughput pipeline to determine the near-atomic-resolution structure of proteins by cryo-electron microscopy (cryo-EM). Over the past five years, cryo-EM has improved the study of biological macromolecules at near-atomic resolution. This project will use two automated electron microscopes and a Titan Krios microscope to build a world-competitive integrated cryo-EM network for structural biology. This research is expected to increase the understanding of molecular events that are central for life.Read moreRead less
New Approaches to Modelling and Analysing Long-Memory Random Processes. The project aims to develop new approaches using infinite-dimensional Markov processes to solving important long-standing problems from the theory of long memory random processes and their applications. It aims to: construct a class of new representations of random processes; derive inequalities for the key numerical characteristics; and, devise and investigate numerical methods for computing the characteristics and for perf ....New Approaches to Modelling and Analysing Long-Memory Random Processes. The project aims to develop new approaches using infinite-dimensional Markov processes to solving important long-standing problems from the theory of long memory random processes and their applications. It aims to: construct a class of new representations of random processes; derive inequalities for the key numerical characteristics; and, devise and investigate numerical methods for computing the characteristics and for performing statistical inference on the long memory models. The accuracy of numerical approximations will be analysed using simulations on supercomputers. Expected outcomes include models and results of practical importance with applications such as intrusion detection problems, cell motility for biological data and telecommunication.Read moreRead less
The impact of copper on protein turnover. This project aims to elaborate a novel discovery by the research team, that a conserved copper-binding site in a group of conserved conjugating enzymes promotes ubiquitination of a range of essential proteins leading to their rapid degradation, which might be a means of maintaining copper homeostasis. This project will employ a range of integrated physicochemical, biochemical and cell biology approaches to illuminate the molecular nature of this copper a ....The impact of copper on protein turnover. This project aims to elaborate a novel discovery by the research team, that a conserved copper-binding site in a group of conserved conjugating enzymes promotes ubiquitination of a range of essential proteins leading to their rapid degradation, which might be a means of maintaining copper homeostasis. This project will employ a range of integrated physicochemical, biochemical and cell biology approaches to illuminate the molecular nature of this copper action on the enzyme and its partners. Expected outcomes include an analytical understanding of the molecular mechanisms of this process, and enhanced interdisciplinary collaboration between experts. Potential benefits include new strategies to intervene in copper-related disorders of aging.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE210100130
Funder
Australian Research Council
Funding Amount
$1,000,000.00
Summary
New Biomolecular Capabilities for the Melbourne Magnetic Resonance Facility. The project aims to integrate new instrumentation, which does not currently exist in Australia, into the Melbourne Biomolecular Nuclear Magnetic Resonance (NMR) facility. This will introduce new capabilities to the Australian NMR community to characterise important biological molecular interactions at low concentrations. This project expects to support existing areas of research strength with new approaches across inter ....New Biomolecular Capabilities for the Melbourne Magnetic Resonance Facility. The project aims to integrate new instrumentation, which does not currently exist in Australia, into the Melbourne Biomolecular Nuclear Magnetic Resonance (NMR) facility. This will introduce new capabilities to the Australian NMR community to characterise important biological molecular interactions at low concentrations. This project expects to support existing areas of research strength with new approaches across interdisciplinary research programs in biochemistry, structural biology, medicinal and natural product chemistry. Expected outcomes from a range of research with a variety of partners will underpin new, potentially commercially valuable, applications across the chemical, pharmaceutical, agricultural or manufacturing industries.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE210100166
Funder
Australian Research Council
Funding Amount
$626,800.00
Summary
High-throughput camera system for biological cryo-electron microscopy. Visualising the structure of biological macromolecules such as proteins and other subcellular components is critical to understand the fundamentals of life. The integration of the Gatan K3 high-throughput camera system with one of the most advanced cryo-electron microscopy facilities in Australia and the Southern Hemisphere will transform the capacity of Australian researchers to study the world around us at the molecular det ....High-throughput camera system for biological cryo-electron microscopy. Visualising the structure of biological macromolecules such as proteins and other subcellular components is critical to understand the fundamentals of life. The integration of the Gatan K3 high-throughput camera system with one of the most advanced cryo-electron microscopy facilities in Australia and the Southern Hemisphere will transform the capacity of Australian researchers to study the world around us at the molecular detail needed to advance innovative research. The addition of this equipment to the University of Wollongong's research facility Molecular Horizons will result in a step change in the areas of bionanotechnology, advanced manufacturing, diagnostics, and many other areas at the interface of biology, chemistry and physics.Read moreRead less
Computational methods for population-size-dependent branching processes. Branching processes are the primary mathematical tool used to model populations that evolve randomly in time. Most key results in the theory are derived under the simplifying assumption that individuals reproduce and die independently of each other. However, this assumption fails in most real-life situations, in particular when the environment has limited resources or when the habitat has a restricted capacity. This project ....Computational methods for population-size-dependent branching processes. Branching processes are the primary mathematical tool used to model populations that evolve randomly in time. Most key results in the theory are derived under the simplifying assumption that individuals reproduce and die independently of each other. However, this assumption fails in most real-life situations, in particular when the environment has limited resources or when the habitat has a restricted capacity. This project aims to develop novel and effective algorithmic techniques and statistical methods for a class of branching processes with dependences. We will use these results to study significant problems in the conservation of endangered island bird populations in Oceania, and to help inform their conservation management.Read moreRead less
New universality in stochastic systems. This project aims to uncover new analyses and effects in the complex behaviour of non-linear systems with random noise. Many systems originate near an unstable equilibrium. This project will develop a new mathematical theory that establishes a universality in the way the long term effect of noise expresses itself as random initial conditions in the dynamics. It will fill gaps in Mathematics and make refinements to existing fundamental scientific laws by in ....New universality in stochastic systems. This project aims to uncover new analyses and effects in the complex behaviour of non-linear systems with random noise. Many systems originate near an unstable equilibrium. This project will develop a new mathematical theory that establishes a universality in the way the long term effect of noise expresses itself as random initial conditions in the dynamics. It will fill gaps in Mathematics and make refinements to existing fundamental scientific laws by including random initial conditions as predicted by our theory. This will advance our understanding of complex systems subjected to noise and will provide significant benefits in the scientific discoveries in Biology, Ecology, Physics and other Sciences where such systems are frequently met.Read moreRead less
Industry Laureate Fellowships - Grant ID: IL230100154
Funder
Australian Research Council
Funding Amount
$2,582,419.00
Summary
Fixing the NDIS: cost, effectiveness and access for psychosocial disability. This project aims to address serious deficits in the operation of the National Disability Insurance Scheme for one of its largest participant groups: people with psychosocial disability. This project expects to develop new data on scheme outcomes, cost-effectiveness and participant experiences to develop an appropriate and implementable program logic to improve supports for this group. Expected outcomes will be scheme r ....Fixing the NDIS: cost, effectiveness and access for psychosocial disability. This project aims to address serious deficits in the operation of the National Disability Insurance Scheme for one of its largest participant groups: people with psychosocial disability. This project expects to develop new data on scheme outcomes, cost-effectiveness and participant experiences to develop an appropriate and implementable program logic to improve supports for this group. Expected outcomes will be scheme reform by implementing a new framework of supports for psychosocial disability and data to improve the operation of national policy for this group more broadly. This should provide significant benefits for the cost-effective operation of the National Disability Insurance Scheme and build research capacity in disability policy.Read moreRead less