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Interdisciplinary Insights Into The Rational Design Of Malaria Therapy And Vaccines
Funder
National Health and Medical Research Council
Funding Amount
$318,768.00
Summary
Malaria is a global health concern with almost half a million deaths annually. There is an urgent need for a highly effective malaria vaccine and new antimalarials. However, despite decades of research into this pathogen, our understanding of what causes illness in a person and how immunity operates is limited. This project will use a mathematical modelling approach to provide a new way to understand infection, as a rapidly changing and intricate process.
Projecting Prevalence By Phase Of Care For Colorectal, Lung, Breast And Prostate Cancer In New South Wales
Funder
National Health and Medical Research Council
Funding Amount
$330,848.00
Summary
Cancer will become the top health issue in Australia due to the growth and ageing of the population. Accurate estimates of the numbers of people in the community at the different stages of their cancer journey (phases of care) now and in the future are required to plan for and provide adequate cancer care services. We will develop statistical models to estimate and predict cancer prevalence by phase of care for four major cancers in New South Wales.
Low Cost High Precision Radiotherapy: A Synergistic Framework For Tumour Tracking During Treatment
Funder
National Health and Medical Research Council
Funding Amount
$318,768.00
Summary
Advances in technology have enabled radiotherapy to become more sophisticated and more efficient at treating cancer. Yet, despite its sophistication, today radiotherapy suffers from a major problem: whilst we routinely image patients prior to treatment, no anatomical information is available during treatment. This project aims to solve this problem by making use of a number of sensors that are already available in a radiotherapy to track the tumours positions during treatment, when it counts.
The Prediction And Prevention Of Caesarean Section For Slow Progress In Labour
Funder
National Health and Medical Research Council
Funding Amount
$227,261.00
Summary
8% of all births are by caesarean section (CS) for slow labour. Bringing on labour just before the due date reduces the chance of CS but we can’t do this for all women. We have a way to predict high risk of CS for slow labour to select women who may benefit from bringing on the labour. We will perform a study where the women at high risk have can have the labour brought on slightly early. The project could result in 6,000 fewer CSs in Australia alone and prevent many complications of CS.
Combating Infectious Diseases: Eco-Epidemiology, Disease Mapping, And Travel Medicine
Funder
National Health and Medical Research Council
Funding Amount
$344,644.00
Summary
Infectious disease outbreaks are driven by complex interactions between humans, animals, vectors, and the environment. Globally, outbreaks have been increasing in frequency and magnitude, e.g. Ebola and SARS. There is an urgent need to improve public health intelligence by accurately identifying the causes, timing, and hotspots. This project will develop advanced modelling strategies for improving our understanding of outbreaks, and optimise public health interventions to protect human health.
Real-time In-vivo Imaging During Lung Cancer Radiotherapy
Funder
National Health and Medical Research Council
Funding Amount
$318,768.00
Summary
Lung tumours move in clinically significant and unpredicable ways. Current radiotherapy is limited by the lack of real-time imaging to monitor tumour motion. The aim of this project is to develop and clinically implement Real-time In-vivo Imaging to enable motion-adaptive radiotherapy and thereby improve treatment outcomes. Real-time In-vivo Imaging is a software technology that will be applicalbe to 90% of modern radiotherapy systems globally and will enable wide access to advanced cancer care.
Methamphetamine Clandestine Laboratories: An Analysis Of The Geo-spatial Dynamics Between Ecological Factors, Pharmacists, Pseudo-runners And Related Health Harms.
Funder
National Health and Medical Research Council
Funding Amount
$320,891.00
Summary
Methamphetamine (MA) manufacture in clandestine laboratories (clan labs) presents serious health and environmental risks beyond the impact on MA users. My fellowship seeks to better understand the interplay between the geography and population features of clan lab locations, the role of pharmacists and pseudo-runners in MA manufacture and MA-related harm. This evidence provides critical information for policy and program development aimed at reducing the MA manufacture and MA-related harm.
Simulating The Long-term Health Economic Impact Of Overweight And Obesity In Australia And Identifying Cost-effective Treatment Or Prevention Strategies
Funder
National Health and Medical Research Council
Funding Amount
$318,768.00
Summary
Increasing levels of obesity in Australia negatively impact on health and at considerable cost to the health system. Recent availability of large individual-level health datasets enables us to develop a better understanding of weight gain on the progression of obesity related co-morbidities, mortality and healthcare costs. This fellowship provides much-needed evidence on obesity interventions and its impact on long-term costs and benefits in Australia to inform future obesity related policies.
Efficacious Targeting Of Therapeutic Stem Cells To Diseased Livers
Funder
National Health and Medical Research Council
Funding Amount
$318,768.00
Summary
This project focuses on the challenging area of effective and optimal dosing of stem cell-based therapy for liver diseases. I will investigate the fate and therapeutic effects of natural, surface-modified stem cells and cell-derived vesicles in the body and in liver regions using mathematical models. My key goal is advance cell therapy by providing better dosing and cell engineering strategies.