Mechanism Of Signal Transduction And Receptor Activation In Ligand Gated Ion Channel Receptors
Funder
National Health and Medical Research Council
Funding Amount
$551,560.00
Summary
This project seeks to provide fundamental new information about the means by which neurotransmitter receptors, which mediate fast synaptic neurotransmission, operate. This knowledge is important since the Cys-loop family of ligand gated ion channel receptors are responsible for a wide range of neuronal signalling and the control of both excitatory and inhibitory receptors. The Cys-loop receptors are modulated by both therapeutic drugs (eg. benzodiazepines, barbiturates, antiemetics) and by recre ....This project seeks to provide fundamental new information about the means by which neurotransmitter receptors, which mediate fast synaptic neurotransmission, operate. This knowledge is important since the Cys-loop family of ligand gated ion channel receptors are responsible for a wide range of neuronal signalling and the control of both excitatory and inhibitory receptors. The Cys-loop receptors are modulated by both therapeutic drugs (eg. benzodiazepines, barbiturates, antiemetics) and by recreational drugs (eg. alcohol, nicotine). They are also targets for development of new therapeutic drugs, such as allosteric modulators of nAChR for memory enhancement, or modulating GlyR to relieve spasticity or chronic pain. The project will use a range of molecular advances made by this and other laboratories to clarify how neurotransmitters enable their receptors to activate and signal. This fundamental information is of major medical significance as defective synaptic transmission, caused by mutations in ligand gated ion channel receptors, gives rise to a number of neurological and psychiatric disease states. The ligand gated receptors are also major targets for therapeutic drugs and the information gained in this study may also provide insights into new ways in which drugs could be used to enhance or inhibit synaptic signalling.Read moreRead less
Enhancing sensory perception and balance control in HMD-based VR. This project seeks to test a revolutionary new theoretical framework for understanding how we perceive our self-motion and maintain postural control when immersed in head-mounted display (HMD) virtual reality (VR). Photorealistic graphical simulations and artificial vestibular stimulation will be used to investigate how visual and non-visual information concerning self-motion is integrated in the brain. The outcomes will reveal ho ....Enhancing sensory perception and balance control in HMD-based VR. This project seeks to test a revolutionary new theoretical framework for understanding how we perceive our self-motion and maintain postural control when immersed in head-mounted display (HMD) virtual reality (VR). Photorealistic graphical simulations and artificial vestibular stimulation will be used to investigate how visual and non-visual information concerning self-motion is integrated in the brain. The outcomes will reveal how multisensory interaction influences our sensory perception and postural control during HMD VR. The knowledge gained is expected to generate new economic benefits by inspiring next-generation technologies that will optimise users' immersive experiences (e.g., virtual exploration and immersive gaming).Read moreRead less
Creating Sustainable Healthcare: Ensuring New Diagnostics Avoid Harms, Improve Outcomes, And Direct Resources Wisely
Funder
National Health and Medical Research Council
Funding Amount
$2,497,658.00
Summary
Novel imaging, biomarkers and genomic tests for risk assessment and early detection are emerging as major forces for change in clinical practice. While providing advances and new benefits for patients, new technologies can also have harmful, unintended consequences - overdiagnosis and overtreatment. This multidisciplinary CRE will investigate how to respond to emerging technologies to optimise health outcomes while avoiding harms and directing healthcare resources wisely.
Improving Linkages For Chronic Disease Prevention In Indigenous Communities: A Quality Improvement Approach.
Funder
National Health and Medical Research Council
Funding Amount
$318,768.00
Summary
Primary health care and public health are often conceived as two entities providing complementary services within the health system. This research aims to better understand how to link these complementary services by using quality improvement methods and to identify successful interventions that facilitate these linkages in the prevention of chronic disease in Indigenous communities.
Evaluating Cancer Screening: Context, Evidence, Values And Ethics
Funder
National Health and Medical Research Council
Funding Amount
$572,460.00
Summary
The research and clinical communities are divided over whether certain forms of cancer screening do more harm than good. This project asks: What is the right thing to do about cancer screening now? Using robust qualitative methodologies, we will study real cases of cancer screening and analyse their ethical implications. Drawing on this data and analysis, we will produce tools to help policy-makers, consumers and professionals make good decisions about cancer screening in future.
Individualising Care For Patients With Chronic Hepatitis C: Predicting Side Effects And Treatment Response Using Genomic And Proteomic Approaches.
Funder
National Health and Medical Research Council
Funding Amount
$55,575.00
Summary
Patients undergoing treatment for hepatitis C must endure a treatment characterized by unpredictable treatment side effects and uncertainty about the likelihood of cure. This project will investigate genetic predictors of treatment related side-effects and protein markers to predict treatment response. Better definition of the risks and benefits of therapy, may facilitate patients and clinicians to make more informed decisions about treatment, thus individualising treatment and potentially impro ....Patients undergoing treatment for hepatitis C must endure a treatment characterized by unpredictable treatment side effects and uncertainty about the likelihood of cure. This project will investigate genetic predictors of treatment related side-effects and protein markers to predict treatment response. Better definition of the risks and benefits of therapy, may facilitate patients and clinicians to make more informed decisions about treatment, thus individualising treatment and potentially improving the safety and efficacy of therapy.Read moreRead less
Patterns of Buyer Behaviour in China. A mainstream interest of marketers is the study of buyer behaviour (i.e., brand choice, repeat-purchase, switching, loyalty, segmentation, etc.) Much is known. But virtually all of this knowledge comes from Western studies. Yet non-Western nations, such as China, are now immensely important trading partners for the West.
This is the first systematic study of buyer behaviour in China to be based on formal analyses of consumer panel data. An assessment wil ....Patterns of Buyer Behaviour in China. A mainstream interest of marketers is the study of buyer behaviour (i.e., brand choice, repeat-purchase, switching, loyalty, segmentation, etc.) Much is known. But virtually all of this knowledge comes from Western studies. Yet non-Western nations, such as China, are now immensely important trading partners for the West.
This is the first systematic study of buyer behaviour in China to be based on formal analyses of consumer panel data. An assessment will be made of how our analytical models, and associated findings, extend to new conditions (e.g., new geographical markets, sub-regions, traditional Chinese goods, different groups of buyers, etc.).Read moreRead less
Linking Brand Equity Modelling and Measurement with Behavioural and Affective Consumer Decision Processes. Brand equity monitoring often fails to account for image-related and habit-entrenched consumer decision rules. This research takes an established brand equity monitoring tool, A C Nielsen's Winning Brands, and incorporates work on decision heuristics into it. Heuristics occur when consumers simplify their decision task using rules sub-optimal with respect to selecting their preferred alte ....Linking Brand Equity Modelling and Measurement with Behavioural and Affective Consumer Decision Processes. Brand equity monitoring often fails to account for image-related and habit-entrenched consumer decision rules. This research takes an established brand equity monitoring tool, A C Nielsen's Winning Brands, and incorporates work on decision heuristics into it. Heuristics occur when consumers simplify their decision task using rules sub-optimal with respect to selecting their preferred alternative, but effective in terms of reducing cognitive effort. The project will conduct a meta-analysis of over 250 branding strategies followed by a new data collection and latent segmentation analysis. The result will be a more comprehensive decision support tool for brand development, focusing management actions and improving marketing efficiency.Read moreRead less
A cognitive model for identifying optimal measures of beliefs. Belief measures are of high practical relevance. One current national example is measurement of beliefs about recycled water, which will affect state and territory governments' water conservation policies. Another is cultural values, measures of which can form the basis for initiatives to improve social harmony in Australia. The knowledge gained, however, is only as good as the validity of the belief measure employed. We will analyse ....A cognitive model for identifying optimal measures of beliefs. Belief measures are of high practical relevance. One current national example is measurement of beliefs about recycled water, which will affect state and territory governments' water conservation policies. Another is cultural values, measures of which can form the basis for initiatives to improve social harmony in Australia. The knowledge gained, however, is only as good as the validity of the belief measure employed. We will analyse the main types of measures used at present and develop improved belief measures which, when published, will increase the quality of research in the social sciences and enhance Australia's international scientific reputation.Read moreRead less
Measuring Marketing Effectiveness: State of the Art, Current Practice and Areas of Leverage. Marketing performs a useful role in society by identifying customer needs, focusing the resources of the firm towards meeting those needs, and communicating to customers how best to access the products available to fulfill their needs. Without good metrics marketing is fragmented and ineffective. By improving the measurement of marketing effort there will be less waste, resulting in higher profits and ....Measuring Marketing Effectiveness: State of the Art, Current Practice and Areas of Leverage. Marketing performs a useful role in society by identifying customer needs, focusing the resources of the firm towards meeting those needs, and communicating to customers how best to access the products available to fulfill their needs. Without good metrics marketing is fragmented and ineffective. By improving the measurement of marketing effort there will be less waste, resulting in higher profits and greater focus and improved customer satisfaction within Australian markets. In global markets, Australian firms will have access to the tools necessary to assist them to better meet the needs of overseas' customers, resulting in improved export performance.Read moreRead less