Environmental Influences In The Establishment Of The Epigenetic Landscape In Children
Funder
National Health and Medical Research Council
Funding Amount
$695,097.00
Summary
The DNA in each of our cells does not exist alone, it is packaged into complex structures called chromosomes, through association with many different proteins. The distribution of these proteins varies along the length of a chromosome depending on the type of cell and this phenomenon is called 'epigenetics', literally meaning 'above the DNA'. Epigenetic analysis is the study of how proteins and other molecules can change the activity of a gene without changing the DNA sequence. All of our cells ....The DNA in each of our cells does not exist alone, it is packaged into complex structures called chromosomes, through association with many different proteins. The distribution of these proteins varies along the length of a chromosome depending on the type of cell and this phenomenon is called 'epigenetics', literally meaning 'above the DNA'. Epigenetic analysis is the study of how proteins and other molecules can change the activity of a gene without changing the DNA sequence. All of our cells use epigenetic changes to help control how they grow and develop. Evidence suggests a direct link between diet and environmental influences on our epigenetic profile. Recent research has traced the origins of many of the health problems of adult life back to the earliest periods of development _ to the time spent in the womb and the first few years of life. If we are born with a low birth weight, we are more likely to get sick later in life. Overwhelming evidence exists that the environment in the womb is critical for a healthy birth weight (and health in later life) and it is thought that epigenetics may be the missing link between this environment, low birth weight, and therefore health in later life. In addition, mounting evidence supports a general link between epigenetic de-regulation and predisposition to disease. However, the timing and the overall contribution of environmental- genetic influences to the establishment of faulty epigenetic markings remain largely unknown. Twins are the best model to study this link as they share similar (but not identical environments) and some share identical genetic makeup. Using twins, Dr Jeffrey Craig and his team will investigate the factors in the prenatal environment that modify specific cells, leading to low birth weight and increase disease risk later in life. They predict that this occurs via specific changes in gene activity caused by epigenetic disruption.Read moreRead less
Applying search theory for eradicating invasive species. Invasive species have major economic and environmental impacts in Australia and are a major cause of extinctions worldwide. Monitoring is crucial for the timely control of invasive species in sensitive environments. Early detection increases the probability of eradication and increased accuracy in detection reduces the impact of control programs on non-target species. Efficient monitoring also is crucial in determining whether eradication ....Applying search theory for eradicating invasive species. Invasive species have major economic and environmental impacts in Australia and are a major cause of extinctions worldwide. Monitoring is crucial for the timely control of invasive species in sensitive environments. Early detection increases the probability of eradication and increased accuracy in detection reduces the impact of control programs on non-target species. Efficient monitoring also is crucial in determining whether eradication has succeeded. Search Theory has been applied for over 60 years in a wide range of non-biological monitoring problems, resulting in large increases in target detection rates. Gains of a similar magnitude in invasive species detection would greatly enhance Australia's capacity to manage these threats.Read moreRead less
Improving external validity of stated choice experiments. This project aims to deliver more accurate estimates of choice behaviour by reducing biases due to choice task complexity in surveys as well as design artefacts. Extracting 'true' preferences is challenging, not only due to possible hypothetical bias, but also due to increasingly complex choice tasks and the existence of design artefacts. This project will investigate the latter two in the context of marketing, transport, health, and envi ....Improving external validity of stated choice experiments. This project aims to deliver more accurate estimates of choice behaviour by reducing biases due to choice task complexity in surveys as well as design artefacts. Extracting 'true' preferences is challenging, not only due to possible hypothetical bias, but also due to increasingly complex choice tasks and the existence of design artefacts. This project will investigate the latter two in the context of marketing, transport, health, and environmental economics, and proposes new methodologies to extract preferences that more closely reflect true behaviour in real markets.Read moreRead less
Diseases of the 21st century are complex with environmental and genetic causes. At the interface of these is Epigenetics - factors not specified by DNA sequence that control genes. Recent data show much of the risk associated with disease is set early in life, even during the time in the womb. The MCRI CDDE laboratory has assembled teams of researchers of diverse expertise investigating epigenetics of human development and complex disease to hopefully prevent or reverse them early in life.
Special Research Initiatives - Grant ID: SR0354461
Funder
Australian Research Council
Funding Amount
$10,000.00
Summary
Australian Panel Data Users Network. Recent years have seen increased concern about how economic, social and technological changes interact with experiences occurring within families, workplaces and communities. Understanding these forces, however, requires panel data that track agents over time. Australia has only recently begun investing heavily in such data, raising concerns about our capacity to capitalize on this investment.
The aims of this network therefore include:
· enhancing the ca ....Australian Panel Data Users Network. Recent years have seen increased concern about how economic, social and technological changes interact with experiences occurring within families, workplaces and communities. Understanding these forces, however, requires panel data that track agents over time. Australia has only recently begun investing heavily in such data, raising concerns about our capacity to capitalize on this investment.
The aims of this network therefore include:
· enhancing the capacity of researchers to undertake panel data research;
· promoting cross-disciplinary research using panel databases;
· facilitating opportunities for contact between panel data researchers; and
· promoting the use of appropriate methods for analysing panel data.
It is expected that large benefits will flow to the community, especially through improved and better informed public debate and government policy-making.Read moreRead less
Increasing Visitor Frequency: approach to understanding and forecasting how cultural attraction visitors respond to various incentives to increase visitation rates. Museums have been steadily losing visitors over the past decade. While current research indicates that this may be attributed to greater leisure competition, little is understood about how people make choices to visit or not to visit cultural attractions. The aim of this project is to develop, demonstrate and test a Random Utility Th ....Increasing Visitor Frequency: approach to understanding and forecasting how cultural attraction visitors respond to various incentives to increase visitation rates. Museums have been steadily losing visitors over the past decade. While current research indicates that this may be attributed to greater leisure competition, little is understood about how people make choices to visit or not to visit cultural attractions. The aim of this project is to develop, demonstrate and test a Random Utility Theory (RUT)-based modelling approach allowing managers of cultural attractions to understand and predict the likely visitation consequences of potential initiatives. We wish to model visitor choices of museums versus other competing attractions to allow museums to identify specific strategic actions (or combinations) to achieve organisational goals.Read moreRead less
Ocular Motility In Autism And Asperger S Disorder: Dissociation Of Motor Deficits.
Funder
National Health and Medical Research Council
Funding Amount
$131,235.00
Summary
We will use ocular motor technology to investigate motor dysfunction in autism and Asperger's disorder, to advance our understanding of the neurobiological bases of these disorders. This will help clarify whether neural networks are differentially disrupted in these disorders, as our previous clinical research suggests. This dissociation and the subsequent development of an ocular motor clincal screen may improve diagnosis, and potentially treatment, of these devastating conditions.
Developing the capacity to model the impact of interventions that target high-risk drinking among young Australians. Alcohol use is a major contributing factor to social and health problems among young Australians. The project will inform the development of effective policy by providing multidisciplinary research evidence and the capacity to model how various interventions impact on the prevalence of alcohol-related problems.
Ethnographies of housing: exploring the role of housing officers in public housing service provision. This research examines the everyday practice of public housing officers working in the Victorian Office of Housing. It aims to analyse the ways that workers exercise discretion, and the patterns of meanings that they construct, through their interactions with clients, departmental managers and other human service providers. It is the first ethnographic study of front-line work in housing servi ....Ethnographies of housing: exploring the role of housing officers in public housing service provision. This research examines the everyday practice of public housing officers working in the Victorian Office of Housing. It aims to analyse the ways that workers exercise discretion, and the patterns of meanings that they construct, through their interactions with clients, departmental managers and other human service providers. It is the first ethnographic study of front-line work in housing services in Australia and builds on comparable work done in the United Kingdom and America. The knowledge generated will inform innovation in public housing services, housing policy debates and emerging programs designed to integrate housing with other human services.Read moreRead less
Industrial Transformation Training Centres - Grant ID: IC200100009
Funder
Australian Research Council
Funding Amount
$4,861,236.00
Summary
ARC Training Centre in Optimisation Technologies, Integrated Methodologies, and Applications (OPTIMA). OPTIMA addresses industry’s urgent need for decision-making tools for global competitiveness: reducing lead times, and financial and environmental costs, while improving efficiency, quality, and agility. Despite strong expertise in academia, industry is yet to fully benefit from optimisation technology due to its high barrier to entry. Connecting industry partners with world-leading interdiscip ....ARC Training Centre in Optimisation Technologies, Integrated Methodologies, and Applications (OPTIMA). OPTIMA addresses industry’s urgent need for decision-making tools for global competitiveness: reducing lead times, and financial and environmental costs, while improving efficiency, quality, and agility. Despite strong expertise in academia, industry is yet to fully benefit from optimisation technology due to its high barrier to entry. Connecting industry partners with world-leading interdisciplinary researchers and talented students, OPTIMA will advance an industry-ready optimisation toolkit, while training a new generation of industry practitioners and over 120 young researchers, vanguarding a highly skilled workforce of change agents for transformation of the advanced manufacturing, energy resources, and critical infrastructure sectors.Read moreRead less