Mechanism Of Signal Transduction And Receptor Activation In Ligand Gated Ion Channel Receptors
Funder
National Health and Medical Research Council
Funding Amount
$551,560.00
Summary
This project seeks to provide fundamental new information about the means by which neurotransmitter receptors, which mediate fast synaptic neurotransmission, operate. This knowledge is important since the Cys-loop family of ligand gated ion channel receptors are responsible for a wide range of neuronal signalling and the control of both excitatory and inhibitory receptors. The Cys-loop receptors are modulated by both therapeutic drugs (eg. benzodiazepines, barbiturates, antiemetics) and by recre ....This project seeks to provide fundamental new information about the means by which neurotransmitter receptors, which mediate fast synaptic neurotransmission, operate. This knowledge is important since the Cys-loop family of ligand gated ion channel receptors are responsible for a wide range of neuronal signalling and the control of both excitatory and inhibitory receptors. The Cys-loop receptors are modulated by both therapeutic drugs (eg. benzodiazepines, barbiturates, antiemetics) and by recreational drugs (eg. alcohol, nicotine). They are also targets for development of new therapeutic drugs, such as allosteric modulators of nAChR for memory enhancement, or modulating GlyR to relieve spasticity or chronic pain. The project will use a range of molecular advances made by this and other laboratories to clarify how neurotransmitters enable their receptors to activate and signal. This fundamental information is of major medical significance as defective synaptic transmission, caused by mutations in ligand gated ion channel receptors, gives rise to a number of neurological and psychiatric disease states. The ligand gated receptors are also major targets for therapeutic drugs and the information gained in this study may also provide insights into new ways in which drugs could be used to enhance or inhibit synaptic signalling.Read moreRead less
An Evaluation Of Trust In A Primary Health Care System
Funder
National Health and Medical Research Council
Funding Amount
$135,550.00
Summary
Trust is a critical issue in the relationships between organisations that need to work together to achieve integrated services for consumers. As organisational representatives get to know one another trust may develop permitting a greater degree of collaboration. In Victoria, the Primary Care Partnerships Strategy process aims to strengthen the relationships between agencies in alocal areas to improve collaboration and achieve services that operate in an integrated way in the provision of servic ....Trust is a critical issue in the relationships between organisations that need to work together to achieve integrated services for consumers. As organisational representatives get to know one another trust may develop permitting a greater degree of collaboration. In Victoria, the Primary Care Partnerships Strategy process aims to strengthen the relationships between agencies in alocal areas to improve collaboration and achieve services that operate in an integrated way in the provision of services to consumers. It is about strengthening the system of care. The aim of this study is to understand how people within a primary care system build and maintain relationships of trust between individuals and between organisations. Individuals will be interviewed to learn how they experience trust and related issues, documents will be analysed to learn about the policy and organisational environments of trust relationships, and the Trust Evaluation Scale used to measure the factors associated with trust over a two year period. The outcomes of this study will be an understanding of how organisations establish the relationships that allow them to collaborate effectively. In particular it will help us understand how they can be encouraged to share the same protocols and procedures, to share information, and become more skilful at managing organisational differences, and it will provide a deeper understanding of relationships between primary health care organisations and the strategies that can help individuals and organisations create trust and collaborate.Read moreRead less