Mechanism Of Signal Transduction And Receptor Activation In Ligand Gated Ion Channel Receptors
Funder
National Health and Medical Research Council
Funding Amount
$551,560.00
Summary
This project seeks to provide fundamental new information about the means by which neurotransmitter receptors, which mediate fast synaptic neurotransmission, operate. This knowledge is important since the Cys-loop family of ligand gated ion channel receptors are responsible for a wide range of neuronal signalling and the control of both excitatory and inhibitory receptors. The Cys-loop receptors are modulated by both therapeutic drugs (eg. benzodiazepines, barbiturates, antiemetics) and by recre ....This project seeks to provide fundamental new information about the means by which neurotransmitter receptors, which mediate fast synaptic neurotransmission, operate. This knowledge is important since the Cys-loop family of ligand gated ion channel receptors are responsible for a wide range of neuronal signalling and the control of both excitatory and inhibitory receptors. The Cys-loop receptors are modulated by both therapeutic drugs (eg. benzodiazepines, barbiturates, antiemetics) and by recreational drugs (eg. alcohol, nicotine). They are also targets for development of new therapeutic drugs, such as allosteric modulators of nAChR for memory enhancement, or modulating GlyR to relieve spasticity or chronic pain. The project will use a range of molecular advances made by this and other laboratories to clarify how neurotransmitters enable their receptors to activate and signal. This fundamental information is of major medical significance as defective synaptic transmission, caused by mutations in ligand gated ion channel receptors, gives rise to a number of neurological and psychiatric disease states. The ligand gated receptors are also major targets for therapeutic drugs and the information gained in this study may also provide insights into new ways in which drugs could be used to enhance or inhibit synaptic signalling.Read moreRead less
Enhancing sensory perception and balance control in HMD-based VR. This project seeks to test a revolutionary new theoretical framework for understanding how we perceive our self-motion and maintain postural control when immersed in head-mounted display (HMD) virtual reality (VR). Photorealistic graphical simulations and artificial vestibular stimulation will be used to investigate how visual and non-visual information concerning self-motion is integrated in the brain. The outcomes will reveal ho ....Enhancing sensory perception and balance control in HMD-based VR. This project seeks to test a revolutionary new theoretical framework for understanding how we perceive our self-motion and maintain postural control when immersed in head-mounted display (HMD) virtual reality (VR). Photorealistic graphical simulations and artificial vestibular stimulation will be used to investigate how visual and non-visual information concerning self-motion is integrated in the brain. The outcomes will reveal how multisensory interaction influences our sensory perception and postural control during HMD VR. The knowledge gained is expected to generate new economic benefits by inspiring next-generation technologies that will optimise users' immersive experiences (e.g., virtual exploration and immersive gaming).Read moreRead less
The Intended and Unintended Impact of Policy for Adaptive Policy Management. The project aims to advance knowledge about the intended and unintended consequences of policy on health and well-being. It expects to innovate through new methods and novel data to integrate policy evaluation into the policy cycle in a timely fashion to prevent harm from occurring. It also leverages technology to track policy effects in real time. Expected outcomes of this project include new knowledge and enhanced pol ....The Intended and Unintended Impact of Policy for Adaptive Policy Management. The project aims to advance knowledge about the intended and unintended consequences of policy on health and well-being. It expects to innovate through new methods and novel data to integrate policy evaluation into the policy cycle in a timely fashion to prevent harm from occurring. It also leverages technology to track policy effects in real time. Expected outcomes of this project include new knowledge and enhanced policy infrastructure using new methods and interdisciplinary approaches. Significant benefits include improvements to: (1) policy management by government departments; (2) the health and wellbeing of the Australians they serve; (3) our Partners' capacity to consult governments on how technology can assist policy management. Read moreRead less
Using Health Economics To Strengthen Ties Between Evidence, Policy And Practice In Chronic Disease
Funder
National Health and Medical Research Council
Funding Amount
$1,925,648.00
Summary
There is a major shortage of researchers with health economics expertise in Australia. This grant will provide training and development for a team of health economists to research chronic diseases covering issues such as: What is the value for money from investment in different treatments? How do such diseases affect the economic circumstances of families? How do we ensure that strategies to address illness work in practice and can be sustained? How do these issues get put on the policy agenda?
Equitable funding for health care: integrating social outcomes. This project will develop an innovative method for decision makers to achieve more equitable allocation of scarce health care resources. Health programs and treatments affect not just health (survival & health related quality of life) but also broader aspects of well-being (e.g. dignity, autonomy, safety). Our current methods for evaluating value for money in health do not capture these aspects. The project will provide benefit by a ....Equitable funding for health care: integrating social outcomes. This project will develop an innovative method for decision makers to achieve more equitable allocation of scarce health care resources. Health programs and treatments affect not just health (survival & health related quality of life) but also broader aspects of well-being (e.g. dignity, autonomy, safety). Our current methods for evaluating value for money in health do not capture these aspects. The project will provide benefit by allowing health system decision makers to achieve fairer allocation of resources across diverse health conditions, interventions and patient populations. Expected outcomes include a new tool for assessing interventions and measuring population health incorporating both health and social outcomes. Read moreRead less
Snake envenoming is a neglected tropical disease and results in numerous deaths, psychological problems and economic burden. Antivenoms aren't readily available in resource poor countries. The CRE will investigate the effects of venom and antivenom to improve understanding of human envenoming. It will also develop tests for early diagnosis of envenoming and undertake clinical trials of antivenom. These studies will be translated back into clinical practice to improve treatment of snake bites.
Regulatory Strategies To Promote Healthier Australian Diets
Funder
National Health and Medical Research Council
Funding Amount
$645,205.00
Summary
Unhealthy diets are a leading cause of ill health. In contrast to our global leadership in tobacco control, Australia remains slow to use law as a tool to support healthy eating. This project will generate new insights on features of effective food policies to target excess sugar consumption. Using an innovative fusion of law and science, its findings will inform and accelerate current proposals to improve food labelling and tax sugary drinks to promote healthier Australian diets.
A cross-national study of the relative impact of an oral component on PhD examination quality, language and practice. High quality doctoral degrees call for the most effective forms of assessment. This project investigates the role of oral examination in PhD assessment, common internationally but not in Australia, and is the first to compare the relative impact of oral and 'no oral' models on examination quality, language and practice.
After the questions: outcomes of routine screening for domestic violence in NSW Health services. Recent research indicates that domestic violence is the leading contributor to death, disability and illness in women aged 15-44 in Australia and leads to health costs of $314 m annually (VicHealth 2004, Access Economics 2004). Routine screening is a low cost measure aimed at prevention and early intervention for domestic violence, which has been successfully introduced for women entering antenatal, ....After the questions: outcomes of routine screening for domestic violence in NSW Health services. Recent research indicates that domestic violence is the leading contributor to death, disability and illness in women aged 15-44 in Australia and leads to health costs of $314 m annually (VicHealth 2004, Access Economics 2004). Routine screening is a low cost measure aimed at prevention and early intervention for domestic violence, which has been successfully introduced for women entering antenatal, early childhood, mental health and drug and alcohol services operated by NSW Health. The research will be the first study of its size to consider the outcomes of routine screening for domestic violence in public health settings in the Australian context.Read moreRead less
Creating A Culture Of Safety And Respect: A Controlled, Mixed Methods Study Of The Effectiveness Of A Behavioural Accountability Intervention To Reduce Unprofessional Behaviours
Funder
National Health and Medical Research Council
Funding Amount
$875,978.00
Summary
Unprofessional behaviours among health professionals are common and are associated with increased patient dissatisfaction and medicolegal risk. Addressing these behaviours is a national issue. Ethos is a structured accountability system involving a process of early, non-punitive and tiered intervention and will be introduced across four Australian hospitals. This research will be the first controlled study to assess the effectiveness of the Ethos program to improve patient safety in Australia.