Carnitine Acetyltransferase (CrAT) Regulates Appetite And Body Weight Through The Melanocortin System
Funder
National Health and Medical Research Council
Funding Amount
$547,087.00
Summary
Carnitine metabolism in peripheral tissues, such as muscle, maintains appropriate cellular metabolism and function. Little is known about carnitine metabolism in specific populations of brain cells regulate food intake and appetite. This project aims to understand how carnitine metabolism affect brain cells that regulate food intake and body weight.
Carnitine Palmitoyl Transferase 1 In POMC Neurons Controls Glucose Homeostasis And Body Weight
Funder
National Health and Medical Research Council
Funding Amount
$474,499.00
Summary
The brain plays a critical role in body weight gain by balancing appetite-inducing and appetite-suppressing signals. An imbalance in this process causes obesity, promotes diabetes and cardiovascular disease. The aim of this research is to identify how appetite-suppressing brain signals are maintained as a method to prevent obesity progression.
Mitochondrial Dysfunction In Cardiac Hypertrophy And Failure
Funder
National Health and Medical Research Council
Funding Amount
$164,821.00
Summary
Heart failure is a disease of wide prevalence in the Western World. In addition to the human toll of heart failure, the economic impact is highly substantial. It remains unclear what causes heart failure, but the effects of calcium and free radicals produced in the mitochondria on muscle function are generally accepted as major contributors. The aim of this project is to understand how calcium and free radicals interact with each other and the mechanisms by which they reduce heart function.