Preclinical Evaluation Of A Novel Allosteric IL-1R Inhibitor (rytvela) For The Prevention Of Perinatal Inflammation-induced Fetal Injury
Funder
National Health and Medical Research Council
Funding Amount
$1,377,827.00
Summary
Interleukin-1 (IL-1) is a potent inflammatory protein involved in many inflammatory disorders, including preterm birth (PTB). Blocking the actions of IL-1 in pregnancies at risk of delivering preterm may protect the fetus from PTB and the long-term harm of exposure to inflammation before birth. Using four different models of antenatal inflammation, we will explore the use of a new IL-1 inhibitor to see if it blocks inflammation ‘in utero’ and improve neonatal health and development.
Predicting Renal, Ophthalmic, And Heart Events In The Aboriginal Community – THE PROPHECY Study
Funder
National Health and Medical Research Council
Funding Amount
$2,574,486.00
Summary
Up to 30% of adult Aboriginal people have diabetes yet our knowledge of the causes and predictors of complications remain incomplete. We have established the PROPHECY Study to assess the levels of complications in Aboriginal people with diabetes; to understand the way that these complications occur, and identify what clinical, social and genetic factors could predict who will get those complications to guide clinical management and prevention.
A Genome-wide Association Scan To Identify Genetic Risk Factors For Sight Threatening Diabetic Retinopathy
Funder
National Health and Medical Research Council
Funding Amount
$982,203.00
Summary
Diabetic eye disease is an important complication of diabetes that can lead to blindness. Very little is known about how diabetes causes eye disease, but genetics is known to play a role. We aim to identify genes that contribute to eye disease in diabetes patients. We will compare genes between patients with diabetes with and without severe diabetic eye disease using cutting edge genomic technology. We hope to be able to better predict risk of blindness and to move towards novel treatments.
Radiostereometric Analysis Of The Effect Of A Large Articulation On Prosthetic Wear And Migration After Hip Replacement
Funder
National Health and Medical Research Council
Funding Amount
$192,186.00
Summary
At total hip replacement, there has been a recent trend to use prostheses with a larger ball and liner in the socket. This may decrease the risk of post-operative dislocation, but may also increase the amount of wear, leading to bone loss and loosening of prostheses, which may then require replacement. This project will use a special type of x-ray to determine whether wear and movement of these new prostheses is clinically acceptable, so that they can be used with confidence in patients.
The Risks And Benefits Of Contemporary Total Hip Replacement
Funder
National Health and Medical Research Council
Funding Amount
$493,530.00
Summary
The number of hip replacements undertaken in Australia is steadily increasing. The most common complications of hip replacements are dislocation and loosening due to bone loss around the implant, requiring complex and expensive revision surgery. This study will investigate the incidence of dislocation and, using a new diagnostic imaging technique, the incidence and amount of bone loss around a relatively new prosthetic material, the outcomes of which are not known despite its increasing use.
Improving student outcomes: coaching teachers in the power of feedback. This project aims to investigate how student outcomes can be augmented through coaching teachers in effective feedback practice. The project addresses a critical problem of stagnating levels of student achievement in Australian schools with the innovative research design combining evidence-based, pedagogies of feedback, formative assessment and instructional coaching to improve teacher practice and ultimately raise student a ....Improving student outcomes: coaching teachers in the power of feedback. This project aims to investigate how student outcomes can be augmented through coaching teachers in effective feedback practice. The project addresses a critical problem of stagnating levels of student achievement in Australian schools with the innovative research design combining evidence-based, pedagogies of feedback, formative assessment and instructional coaching to improve teacher practice and ultimately raise student achievement levels. The project aims to guide policy implementation in pedagogy to raise the quality of teaching standards and to improve learning outcomes for Australian students. Ultimately, outcomes from the research will help close the gap for low achieving students, and challenge and extend those who may already be meeting required benchmarks. Read moreRead less
Engaging Students during the Early Years of Secondary School. This project aims to design, test and share sustainable strategies to support teachers and enable students from low socioeconomic communities to achieve success. The greatest decreases in students’ interest and effort occur when they transition into secondary school, with students from low socioeconomic communities at greatest risk of disengagement. What can teachers do to engage their students during this key life transition? This pr ....Engaging Students during the Early Years of Secondary School. This project aims to design, test and share sustainable strategies to support teachers and enable students from low socioeconomic communities to achieve success. The greatest decreases in students’ interest and effort occur when they transition into secondary school, with students from low socioeconomic communities at greatest risk of disengagement. What can teachers do to engage their students during this key life transition? This project plans to identify teacher behaviours that motivate students in their first year at secondary school. Using an experimental design with a representative sample of 150 teachers and 1500 students in low socioeconomic areas across three states, the project plans to test whether an online professional learning program for teachers can improve student engagement and achievement. This cost-effective and scalable intervention is designed for widespread dissemination to Australian teachers.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE150100926
Funder
Australian Research Council
Funding Amount
$336,027.00
Summary
How Australian high schools educate young people for global citizenship. The increasingly globalised world requires education and schooling in Australia to provide young people with the knowledge, skills and attributes needed to participate fully as global citizens. While the goals of Australian schooling and the national Australian Curriculum highlight the importance of preparing students for global citizenship, little is known about how schools and teachers interpret and apply this Curriculum. ....How Australian high schools educate young people for global citizenship. The increasingly globalised world requires education and schooling in Australia to provide young people with the knowledge, skills and attributes needed to participate fully as global citizens. While the goals of Australian schooling and the national Australian Curriculum highlight the importance of preparing students for global citizenship, little is known about how schools and teachers interpret and apply this Curriculum. This project aims to use qualitative research methods to determine teachers' work and students' experiences, providing the first detailed account of educating students for global citizenship in Australian schools. The project aims to contribute to improved educational policy and practice, both in Australia and internationally.Read moreRead less
The adequacy and sustainability of self-managed superannuation funds: Governance, performance, asset allocation, fee structure and compliance. This project will provide research to aid decision makers in policy formation and setting on governance, regulatory and performance issues relating to Self-Managed Superannuation Funds (SMSFs), which now make up the largest proportion of superannuation assets, accounting for over 30% of the total $1.1 trillion of superannuation assets in Australia. Empir ....The adequacy and sustainability of self-managed superannuation funds: Governance, performance, asset allocation, fee structure and compliance. This project will provide research to aid decision makers in policy formation and setting on governance, regulatory and performance issues relating to Self-Managed Superannuation Funds (SMSFs), which now make up the largest proportion of superannuation assets, accounting for over 30% of the total $1.1 trillion of superannuation assets in Australia. Empirically driven advice to the Government and the general community on these issues is of substantial importance given the need for retirees to be self-financing and the current adverse conditions experienced in today's financial environment. Research stemming from this project will highlight the value proposition SMSFs may or may not be providing to the superannuation industry.Read moreRead less
Increasing the rural medical workforce: investigating personal traits to enhance our understanding and improve training of rural registrars. This project will research new methodologies for increasing the number of rural doctors in Australia. A better understanding of those individuals best suited for rural practice will provide value for money to the Government by making the most efficient use of initiatives to increase recruitment and retention of the rural workforce.