The Role Of Purines In Age Related Macular Degeneration
Funder
National Health and Medical Research Council
Funding Amount
$682,434.00
Summary
Age Related Macular degeneration (AMD) is a leading cause of blindess. In this project we will examine a possible cause for the development and progression of early AMD. In particular we will determine whether signaling of immune cells via receptors called purinergic receptors influences the removal of cellular debris as we age, predisposing people to the disease.
Do Activated Retinal Microglia Mediate Neurotoxicity In Background Diabetic Retinopathy?
Funder
National Health and Medical Research Council
Funding Amount
$435,589.00
Summary
Diabetic retinopathy, a frequent complication of Type 1 and Type 2 diabetes, is the commonest cause of blindness in working age individuals. Prior to the growth of blindness-causing new vessels in the eye we now know that there is a gradual loss of neurons in the retina. This project will investigate whether the resident immune cells in the retina, which are normally neuroprotective, become neurotoxic during episodes of systemic inflammation (e.g. bacterial or viral infections).