MICROFABRICATED DEVICES: A SIGNIFICANT ADVANCE FOR THE DETECTION AND MOLECULAR ANALYSES OF CIRCULATING CANCER CELLS?
Funder
National Health and Medical Research Council
Funding Amount
$422,107.00
Summary
Using advanced microfabrication concepts, this project aims to develop a platform technology able to capture tumour cells circulating in the blood of cancer patients. Although present only in extremely small numbers, these cells provide invaluable insights into the pathophysiology of the disease and consequently provide vital diagnostic and prognostic information. Molecular analyses of these cancer cells could ultimately enable the design of improved and personalized cancer treatment.
Rapid point-of-care detection of genomic variations for personalised medicine. Selecting treatment based on a person’s genetic profile can improve drug safety and efficacy, but the application is hampered by the inconvenience, slow result turnaround and high cost of current lab-based tests. Full implementation of personalised medicine in clinical practice requires a point-of-care testing system. This project aims to overcome the challenges involved in developing such a system by validating novel ....Rapid point-of-care detection of genomic variations for personalised medicine. Selecting treatment based on a person’s genetic profile can improve drug safety and efficacy, but the application is hampered by the inconvenience, slow result turnaround and high cost of current lab-based tests. Full implementation of personalised medicine in clinical practice requires a point-of-care testing system. This project aims to overcome the challenges involved in developing such a system by validating novel rapid genotyping methods and developing ultrasensitive real-time DNA detection that will be integrated on a single chip platform to facilitate a small, low cost and reliable test device. The technology will be readily adaptable to areas where prompt access to genomic information is valuable, such as disease diagnosis and risk prediction.Read moreRead less
A novel platform-technology for long-term subcutaneous neurophysiology. This project aims to develop a novel miniature device for subcutaneous and tetherless brain sensing. It addresses the lack of a device solution for brain-sensing that combines ultra-long-term reliable sensing capability and small dimensions for minimally-invasive procedures. We achieve this through our novel electrode architecture that significantly enhances the quality and reliability of recorded brain signals. We introduce ....A novel platform-technology for long-term subcutaneous neurophysiology. This project aims to develop a novel miniature device for subcutaneous and tetherless brain sensing. It addresses the lack of a device solution for brain-sensing that combines ultra-long-term reliable sensing capability and small dimensions for minimally-invasive procedures. We achieve this through our novel electrode architecture that significantly enhances the quality and reliability of recorded brain signals. We introduce a platform technology designed for subscalp anatomy with future use in various brain-machine interfacing applications relying on reliable, long-term and easy-to-implant systems. This project's device manufacturing, training, and intellectual property are expected to strengthen Australia's position in bioelectronics.Read moreRead less
Novel graphene nanostructures: modelling, synthesis, fabrication and characterisation. As a key nanomaterial for future electronics, graphene is rapidly becoming one of the most promising frontier areas of nanotechnology throughout the world. This project aims to develop a new class of graphene nanostructures that hold great potential for large-scale applications in the next generation nanoelectronic devices, sensors, solar cells and light emitting devices. This project will significantly enhan ....Novel graphene nanostructures: modelling, synthesis, fabrication and characterisation. As a key nanomaterial for future electronics, graphene is rapidly becoming one of the most promising frontier areas of nanotechnology throughout the world. This project aims to develop a new class of graphene nanostructures that hold great potential for large-scale applications in the next generation nanoelectronic devices, sensors, solar cells and light emitting devices. This project will significantly enhance the international competitiveness of Australia in the areas of new materials and nanotechnology and will help place Australia at the forefront of nanotechnology. This project will produce high quality PhD students in nanotechnology.Read moreRead less
Diamond glass: An all-carbon technology for neural networks and biosensing. This project aims to use plasma deposition to synthesise diamond glass with the highest purity and the most diamond-like character so that it meets the strict requirements for emerging device applications. The extreme properties of diamond glass arise from the diamond-like bonding of the majority of its atoms. This amorphous, wide bandgap semiconductor is also the hardest known glass. The maximum diamond-like content pos ....Diamond glass: An all-carbon technology for neural networks and biosensing. This project aims to use plasma deposition to synthesise diamond glass with the highest purity and the most diamond-like character so that it meets the strict requirements for emerging device applications. The extreme properties of diamond glass arise from the diamond-like bonding of the majority of its atoms. This amorphous, wide bandgap semiconductor is also the hardest known glass. The maximum diamond-like content possible in diamond glass coatings is unknown, so determining its ultimate performance is difficult. Expected applications include medical diagnostics, non-volatile memories and programmable chips.Read moreRead less
Thermoelectric devices for high-performing localised coolers. This project aims to develop a lightweight, low-energy-consumption, and high-durability wearable thermoelectric cooler for localised cooling using a novel industry-led approach, coupled with device design and materials engineering strategies. The key breakthrough expected is to design wearable thermoelectric coolers by using flexible substrates and thermoelectric materials with engineered chemistry and unique structures for achieving ....Thermoelectric devices for high-performing localised coolers. This project aims to develop a lightweight, low-energy-consumption, and high-durability wearable thermoelectric cooler for localised cooling using a novel industry-led approach, coupled with device design and materials engineering strategies. The key breakthrough expected is to design wearable thermoelectric coolers by using flexible substrates and thermoelectric materials with engineered chemistry and unique structures for achieving localised, instant, and controllable cooling with super low power input for personal usage in building and mining industry. Expected outcomes include innovative technologies for achieving high-efficiency cooling, which will provide significant economic and commercial benefits for Australia.Read moreRead less
Surface Integrity Characterization of Sapphire Wafers for Wireless and Fibre Optic Semiconductor Industry. This project aims to uncover the mechanism of surface integrity in sapphire wafers and thus to establish its relationship with the quality processing of integrated circuits. The project will comprehensively consider surface damage, residual stresses, thermal shock and dislocation evolution as an organic whole to provide an effective solution to the problems in the current production practic ....Surface Integrity Characterization of Sapphire Wafers for Wireless and Fibre Optic Semiconductor Industry. This project aims to uncover the mechanism of surface integrity in sapphire wafers and thus to establish its relationship with the quality processing of integrated circuits. The project will comprehensively consider surface damage, residual stresses, thermal shock and dislocation evolution as an organic whole to provide an effective solution to the problems in the current production practice. Problems caused by unsatisfactory surface integrity represent a major outlay for the wireless and fibre optic semiconductor industry. The proposed research holds the very real possibility of reducing the capital cost and enhancing the quality of the integrated circuits of high capacity.Read moreRead less
Higher Order Effects in Miniaturized Piezoelectric Devices. The national benefits of this project are: (a) We will provide opportunities to two postdoctoral researchers to pursue cutting edge research on electromagnetic radiation/scattering and self-heating phenomena in microelectronic devices involving ultrathin lossy electrodes. (b) We will provide industry-oriented research on coating and shielding problems in microelectronic devices to two postgraduate students. (c) We will team up with worl ....Higher Order Effects in Miniaturized Piezoelectric Devices. The national benefits of this project are: (a) We will provide opportunities to two postdoctoral researchers to pursue cutting edge research on electromagnetic radiation/scattering and self-heating phenomena in microelectronic devices involving ultrathin lossy electrodes. (b) We will provide industry-oriented research on coating and shielding problems in microelectronic devices to two postgraduate students. (c) We will team up with world leading industrial partners and transfer high-tech know-how to Australia. (d) The outcomes of our research will position Australia as the prime focal point for the design, modelling and simulation of microacoustic devices.Read moreRead less
Industrial Transformation Research Hubs - Grant ID: IH170100013
Funder
Australian Research Council
Funding Amount
$2,962,655.00
Summary
ARC Research Hub for Digital Enhanced Living. The ARC Research Hub for Digital Enhanced Living aims to address the growing challenges of aging people living in their own home or residential care. This will be through inventing new personalised medical technologies through an innovative approach, with a multi-disciplinary team leveraging diverse expertise. An enhanced capacity to create and deploy fit-for-purpose personalised health solutions will result in revenues from new and repurposed device ....ARC Research Hub for Digital Enhanced Living. The ARC Research Hub for Digital Enhanced Living aims to address the growing challenges of aging people living in their own home or residential care. This will be through inventing new personalised medical technologies through an innovative approach, with a multi-disciplinary team leveraging diverse expertise. An enhanced capacity to create and deploy fit-for-purpose personalised health solutions will result in revenues from new and repurposed devices, analytics and integration platforms. New jobs and improved care will see cost reductions, better use of resources and enhanced mental, physical and social well-being.Read moreRead less
Unified platform for real time QA in radiation therapy in brachytherapy based on high resolution silicon detectors (Magic Plate). This project will design and manufacture new devices for measuring the amount of radiation given to the patient during radiotherapy. This will improve the accuracy and safety of cancer treatment as well as greatly reducing the time needed to perform essential safety checks.