EphA2 And EphA3 Maintain Tumour Initiating Cells And Are Therapeutic Targets In Brain Cancer
Funder
National Health and Medical Research Council
Funding Amount
$612,860.00
Summary
High-grade glioma (HGG) is the most common adult brain cancer; current treatments have increased survival times by months only. Our studies have shown brain cancer specific expression of a family of cell surface proteins called Eph receptors. Furthermore we have shown targeting these receptors with Eph antibodies leads to a significant reduction in brain cancer tumour growth. We now propose to test targeting these receptors in combination to achieve greater responses with minimal side effects.
Contribution Of MDSC-derived Cysteine Cathepsins In Breast Cancer Metastasis To Bone
Funder
National Health and Medical Research Council
Funding Amount
$320,891.00
Summary
Cathepsins are enzymes called proteases that function to cleave specific proteins, a process that is important for many normal cellular functions. Aberrant cathepsin activity can result in a number of pathologies, including cancer and inflammation. We are developing tools called activity-based probes to study the function of cathepsins in disease. Specifically, we will investigate their activity within cells of the immune system with the goal of developing novel therapeutic approaches.