The mobilome of the anaerobic methanotrophic archaea Methanoperedenaceae. Microorganisms play a critical role in regulating Earth’s climate, but how they are affected by our rapidly changing environment is not well understood. This Discovery project will study a group of microorganisms found in freshwater sediment that can consume the potent greenhouse gas methane before it is released into the atmosphere. We have developed new methods to investigate how genetic material is exchanged between mic ....The mobilome of the anaerobic methanotrophic archaea Methanoperedenaceae. Microorganisms play a critical role in regulating Earth’s climate, but how they are affected by our rapidly changing environment is not well understood. This Discovery project will study a group of microorganisms found in freshwater sediment that can consume the potent greenhouse gas methane before it is released into the atmosphere. We have developed new methods to investigate how genetic material is exchanged between microorganisms, and how this helps them adapt to environmental changes. Together, this will ultimately help us develop better climate change prediction models and contribute to our understanding of microbial communities that are crucial for environmental health.Read moreRead less
A novel microbial process breaking through the nitrogen cycling. Nitrogen transformation is central to life on Earth. This project will challenge a century-old paradigm that microorganisms must cooperate in a team to convert nitrogen from organic- to inorganic forms. We will carry out the first-ever systematic investigation of a novel process, where a single organism mediates complete ammonification and ammonia oxidation, directly connecting organic- and inorganic nitrogen. By revealing metaboli ....A novel microbial process breaking through the nitrogen cycling. Nitrogen transformation is central to life on Earth. This project will challenge a century-old paradigm that microorganisms must cooperate in a team to convert nitrogen from organic- to inorganic forms. We will carry out the first-ever systematic investigation of a novel process, where a single organism mediates complete ammonification and ammonia oxidation, directly connecting organic- and inorganic nitrogen. By revealing metabolic pathways, characterising ecophysiological properties, isolating key microorganisms and exploring their application potential, this project will change our fundamental understanding of global nitrogen cycling, improve the sustainability of water management, and contribute to the circular economy transitionRead moreRead less
Australian Laureate Fellowships - Grant ID: FL230100159
Funder
Australian Research Council
Funding Amount
$3,330,000.00
Summary
From a descriptive to a predictive understanding of the human microbiome. Microorganisms inhabit every imaginable environment on Earth. Despite advances in characterising microbial communities, our understanding is largely descriptive and a detailed appreciation of their complexity eludes us. This Laureate project aims to transform microbial ecology into a predictive science, through intensive investigation of the human gut microbiome as a model ecosystem. Major challenges in microbiology are ex ....From a descriptive to a predictive understanding of the human microbiome. Microorganisms inhabit every imaginable environment on Earth. Despite advances in characterising microbial communities, our understanding is largely descriptive and a detailed appreciation of their complexity eludes us. This Laureate project aims to transform microbial ecology into a predictive science, through intensive investigation of the human gut microbiome as a model ecosystem. Major challenges in microbiology are expected to be overcome, with new knowledge for predicting how microorganisms influence, and are influenced by, their environment. Ultimately this knowledge can help us manipulate microbial communities in diverse ecosystems to our advantage – protecting the planet’s natural assets, and improving agriculture and human health.Read moreRead less
Can cyanobacteria use organic nutrients to thrive in future oceans? Marine cyanobacteria are central to regulating the global climate and underpin entire marine food webs. Though they possess genes necessary to uptake diverse organic nutrients, we know very little about whether and how organic nutrients shape the physiology and ecology of cyanobacteria. Using our innovative high-throughput approach, this project aims to systematically characterise organic nutrient uptake in picocyanobacteria. O ....Can cyanobacteria use organic nutrients to thrive in future oceans? Marine cyanobacteria are central to regulating the global climate and underpin entire marine food webs. Though they possess genes necessary to uptake diverse organic nutrients, we know very little about whether and how organic nutrients shape the physiology and ecology of cyanobacteria. Using our innovative high-throughput approach, this project aims to systematically characterise organic nutrient uptake in picocyanobacteria. Our molecules-to-ecosystems approach expects to transform our understanding of alternate nutrient acquisition in cyanobacteria and how it may shape populations of these important photosynthetic organisms in a rapidly-changing ocean landscape. Read moreRead less
Evolution and mechanisms of interactions in biofilm communities. This project aims to study the long-term experimental evolution of a mixed species bacterial biofilm community. This project expects to gain understanding of the genetic and physiological basis of community evolution. Expected outcomes of this project will be an understanding of how synthetic communities evolve. This will significantly benefit the use of synthetic communities relevant to fields such as antibiotic design, biotechnol ....Evolution and mechanisms of interactions in biofilm communities. This project aims to study the long-term experimental evolution of a mixed species bacterial biofilm community. This project expects to gain understanding of the genetic and physiological basis of community evolution. Expected outcomes of this project will be an understanding of how synthetic communities evolve. This will significantly benefit the use of synthetic communities relevant to fields such as antibiotic design, biotechnology, bioremediation, and synthetic biology where evolution can be inhibited or exploited, respectively.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE230100373
Funder
Australian Research Council
Funding Amount
$447,320.00
Summary
The role of resource fluctuations in structuring microbial communities. The flow of nutrients through ecological systems fluctuates through time and yet the impact this variability has on the maintenance of biodiversity is poorly understood. Drawing on emerging theory and a tight integration of modelling and experiments in a model microbial system, this project aims to investigate the impact of modified nutrient regimes on the structure and stability of ecological communities. This project expec ....The role of resource fluctuations in structuring microbial communities. The flow of nutrients through ecological systems fluctuates through time and yet the impact this variability has on the maintenance of biodiversity is poorly understood. Drawing on emerging theory and a tight integration of modelling and experiments in a model microbial system, this project aims to investigate the impact of modified nutrient regimes on the structure and stability of ecological communities. This project expects to generate new knowledge at the forefront of research into diversity maintenance, ecosystem functioning and higher-order interactions. The outcomes should provide a deep mechanistic understanding of microbial community dynamics, with applications from animal health to environmental flows and insect pest management.Read moreRead less
Can eco-evolutionary theories explain outcomes of microbiome coalescence . Environmental microbial communities are among the most abundant and diverse natural communities, responsible for many ecologically and economically important ecosystem functions, including primary productivity and climate regulation. This project aims to identify the biotic and abiotic factors that regulate community and functional outcomes of microbiome coalescence (the mixing of two different communities) caused by natu ....Can eco-evolutionary theories explain outcomes of microbiome coalescence . Environmental microbial communities are among the most abundant and diverse natural communities, responsible for many ecologically and economically important ecosystem functions, including primary productivity and climate regulation. This project aims to identify the biotic and abiotic factors that regulate community and functional outcomes of microbiome coalescence (the mixing of two different communities) caused by natural and anthropogenic activities. The outcomes will provide a unifying ecological framework to predict variation in microbiomes across different scales, ecosystem types and disturbances, and will generate critical knowledge for the development of effective microbiome products, a rapidly growing industryRead moreRead less
Defining the biological boundaries to sustain extant life on Mars. Key challenges for life are access to water & energy, and in cold, arid environments trace gas chemotrophy is used by soil microbiomes to sustain life. Given the cold, hyper-arid conditions on the Martian surface are analogues to ice-free regions of Antarctica, atmospheric chemoautotrophic ecosystems are the most promising ecological model for Martian life in the present or recent past. This project is significant, as it aims to ....Defining the biological boundaries to sustain extant life on Mars. Key challenges for life are access to water & energy, and in cold, arid environments trace gas chemotrophy is used by soil microbiomes to sustain life. Given the cold, hyper-arid conditions on the Martian surface are analogues to ice-free regions of Antarctica, atmospheric chemoautotrophic ecosystems are the most promising ecological model for Martian life in the present or recent past. This project is significant, as it aims to define the limits to energy, water and carbon production via trace gas chemotrophy. We will integrate biology with astrophysics to identify at which point life ceases. Expected outcomes include new knowledge on the biological envelope, with benefits to include the identification of Martian regions for exploration.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE230101346
Funder
Australian Research Council
Funding Amount
$418,893.00
Summary
Cave microbial metabolism as a missing biogeochemical sink. The aim of this project is to unveil the microbial biodiversity, novel metabolic capabilities and chemosynthetic primary production of subsurface ecosystems, such as those found in caves. Leveraging a powerful blend of geospatial, molecular and biogeochemical approaches this project expects to identify the microbial basis of subsurface biogeochemical processes driving the earth’s major elementary cycles. Expected outcomes include a pred ....Cave microbial metabolism as a missing biogeochemical sink. The aim of this project is to unveil the microbial biodiversity, novel metabolic capabilities and chemosynthetic primary production of subsurface ecosystems, such as those found in caves. Leveraging a powerful blend of geospatial, molecular and biogeochemical approaches this project expects to identify the microbial basis of subsurface biogeochemical processes driving the earth’s major elementary cycles. Expected outcomes include a predictive framework to assess and upscale the impact of these microbial communities on the environment. Benefits include predicting and responding to climate risks, such as the desertification of agricultural soils, by uncovering how microorganisms respond to nutrient and carbon depletion.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE240100842
Funder
Australian Research Council
Funding Amount
$455,057.00
Summary
Roles of emerging pollutants in spreading antimicrobial resistance. Antimicrobial resistance is a growing global challenge, yet the impact of environmental agents on the spread of antimicrobial resistance is poorly understood. Drawing on my recent findings and a tight integration of a model microbial ecology system, this project aims to investigate the impact of environmental pollutants on the colonisation and spread of antimicrobial resistance in situ ecological communities. This project expect ....Roles of emerging pollutants in spreading antimicrobial resistance. Antimicrobial resistance is a growing global challenge, yet the impact of environmental agents on the spread of antimicrobial resistance is poorly understood. Drawing on my recent findings and a tight integration of a model microbial ecology system, this project aims to investigate the impact of environmental pollutants on the colonisation and spread of antimicrobial resistance in situ ecological communities. This project expects to generate new knowledge at the forefront of research into antimicrobial resistance in a complex ecosystem. The outcomes should provide a deep mechanistic understanding of environmental factors associated with antimicrobial resistance, with applications to antimicrobial resistance risk management for One Health.Read moreRead less