Mosquito-borne alphaviruses such as Ross River and chikungunya viruses cause widespread epidemics and exert extreme pressure on the public health systems of affected regions. Alphaviruses spreads to joints and triggers a severe disease in those affected. There are no effective treatments or vaccines. The project will investigate virus-host interaction at the bite site. The outcome will be new knowledge to treat infection at the mosquito bite site to prevent joint disease.
Novel Insights Into The Pathobiology Of Alphavirus Infections
Funder
National Health and Medical Research Council
Funding Amount
$827,660.00
Summary
Infections with mosquito-borne viruses are increasing at an alarming rate worldwide. Ross River virus is endemic in parts of Australia, PNG and Pacific islands, while chikungunya virus is distributed globally and causes recurrent pandemics that involve millions of people. These viruses cause severe musculoskeletal disease for several months after infection. This project aims to establish how these viruses interact with the human host to cause disease and may provide a basis for new treatments.
New Insights Into Viral Inflammatory Disease Mechanisms And Approaches To Therapy
Funder
National Health and Medical Research Council
Funding Amount
$631,010.00
Summary
This fellowship aims to establish how viruses cause disease, including how they evade the immune response to persist and cause disease for prolonged periods. My vision is that knowing how the virus and the immune system interact to determine disease severity will assist in devising new treatments and prevention programs to lessen the impact of viral diseases in Australia and worldwide.
Sulfur Cycling in Toxic Oozes, Microbialites and Petroleum. This project will apply compound specific sulfur isotope analyses to sulfur-rich deposits from extreme environments including sulfidic black oozes (Peel-Harvey estuary); modern microbialites (for example, Shark Bay) and oils/source rocks (established and frontier oil fields). Sulfur isotopic data, integrated with other stable isotopic and molecular data, will greatly assist the study of sulfur biogeochemical cycles and mechanisms of org ....Sulfur Cycling in Toxic Oozes, Microbialites and Petroleum. This project will apply compound specific sulfur isotope analyses to sulfur-rich deposits from extreme environments including sulfidic black oozes (Peel-Harvey estuary); modern microbialites (for example, Shark Bay) and oils/source rocks (established and frontier oil fields). Sulfur isotopic data, integrated with other stable isotopic and molecular data, will greatly assist the study of sulfur biogeochemical cycles and mechanisms of organic sulfurisation at different diagenetic stages or geological ages. The project aims to address national concerns through measuring the respective impact of anthropogenic and natural changes on environments, helping to understand the evolution of life on Earth and contributing to efficient discovery of our natural petroleum systems.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE210100028
Funder
Australian Research Council
Funding Amount
$3,000,000.00
Summary
Australian Membership of the International Ocean Discovery Program. This proposal is for an 18-month membership of the International Ocean Discovery Program (IODP), the world’s largest collaborative research program in Earth and Ocean sciences. The Program studies the history and current activity of the Earth by conducting seagoing coring expeditions and monitoring of instrumented boreholes, using globally unique infrastructure that Australians would otherwise have no access to. Program outcomes ....Australian Membership of the International Ocean Discovery Program. This proposal is for an 18-month membership of the International Ocean Discovery Program (IODP), the world’s largest collaborative research program in Earth and Ocean sciences. The Program studies the history and current activity of the Earth by conducting seagoing coring expeditions and monitoring of instrumented boreholes, using globally unique infrastructure that Australians would otherwise have no access to. Program outcomes include understanding past global environmental change on multiple time scales, the deep biosphere, plate tectonics, formation and distribution of resources, and generation of hazards. These outcomes are paramount to Australia’s national science and research priorities, and societal and economic prosperity.Read moreRead less
Alleviating herbicide damage to crops by using fulvate and manganese. Glyphosate is a widely used herbicide, but its drift can cause growth depression in sensitive plants such as wheat by reducing uptake of metallic micronutrients, particularly manganese. In pot and field trials, this project aims to assess the alleviating potential of fulvate and manganese on growth and micronutrient uptake by wheat exposed to glyphosate drift. The influence of land management on the effect of these treatments ....Alleviating herbicide damage to crops by using fulvate and manganese. Glyphosate is a widely used herbicide, but its drift can cause growth depression in sensitive plants such as wheat by reducing uptake of metallic micronutrients, particularly manganese. In pot and field trials, this project aims to assess the alleviating potential of fulvate and manganese on growth and micronutrient uptake by wheat exposed to glyphosate drift. The influence of land management on the effect of these treatments will also be assessed. The underlying mechanisms will be characterised, eg. by determining metal speciation in soil and assessing soil microbial community composition. The outcome of this project will contribute to sustainable agriculture by giving land managers options to reduce glyphosate damage in sensitive crops.Read moreRead less
Accelerated tailings remediation with plant and microbial biotechnologies. The Australian alumina industry produces 32 million tonnes of bauxite residue (alumina refining tailings) each year, most of which is stored in perpetuity in landfill-type tailings storage facilities. The high pH, high salinity, lack of plant nutrients, and poor physical properties of bauxite residue are major barriers to safe storage and successful closure of tailings storage facilities. Existing remediation approaches a ....Accelerated tailings remediation with plant and microbial biotechnologies. The Australian alumina industry produces 32 million tonnes of bauxite residue (alumina refining tailings) each year, most of which is stored in perpetuity in landfill-type tailings storage facilities. The high pH, high salinity, lack of plant nutrients, and poor physical properties of bauxite residue are major barriers to safe storage and successful closure of tailings storage facilities. Existing remediation approaches are expensive, slow, and often ineffective. We will deliver new microbial- and plant-driven biotechnologies for rapid, cost-effective remediation of bauxite residue. This will enable safe, sustainable closure of storage facilities, and safeguard the strong contribution of this $15 billion industry to Australia's economy. Read moreRead less
Mitigating the risk of cyanobacterial blooms in wastewater ponds. Cyanobacterial blooms in wastewater treatment plants impact on effluent quality and the utility of recycled water, posing a significant risk to the economy, the environment and public health. To understand the causes of cyanobacterial blooms in pond-based wastewater treatment plants and the risk they pose, this project will use the latest molecular techniques to examine how the microbial communities within these systems interact w ....Mitigating the risk of cyanobacterial blooms in wastewater ponds. Cyanobacterial blooms in wastewater treatment plants impact on effluent quality and the utility of recycled water, posing a significant risk to the economy, the environment and public health. To understand the causes of cyanobacterial blooms in pond-based wastewater treatment plants and the risk they pose, this project will use the latest molecular techniques to examine how the microbial communities within these systems interact with each other and their surrounding environment to form blooms and produce toxins and other harmful metabolites. Such knowledge will inform risk assessment and provide strategies for the mitigation of future bloom events, improving the security of our increasingly valuable recycled water resources.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE130100019
Funder
Australian Research Council
Funding Amount
$580,000.00
Summary
A transportable containerised laboratory for rapid cell sorting and high-resolution bioimaging of living aquatic microbes in field locations. This project will deliver a transportable, unique laboratory for the rapid isolation and high-resolution analysis of living microbes immediately after sampling from the sea or waterways. It will be the first of its kind in Australia and deliver new knowledge of the role of these organisms in their natural habitats.