Competition or cooperation between marine biofilm bacteria recycling POM? Biofilms develop on any wetted surface by adhesion and subsequent growth of microorganisms. Recycling the energy, carbon and nitrogen contained in oceanic particulate organic matter (POM) is a global process essential for life on Earth. Ocean POM is degraded by its biofilm consortia, particularly bacteria secreting digestive enzymes. It is not known whether biofilm bacteria compete or cooperate in recycling POM. This proj ....Competition or cooperation between marine biofilm bacteria recycling POM? Biofilms develop on any wetted surface by adhesion and subsequent growth of microorganisms. Recycling the energy, carbon and nitrogen contained in oceanic particulate organic matter (POM) is a global process essential for life on Earth. Ocean POM is degraded by its biofilm consortia, particularly bacteria secreting digestive enzymes. It is not known whether biofilm bacteria compete or cooperate in recycling POM. This project combines microscopy image analysis, flow cytometry and molecular genetics to determine bacterial interactions quantitatively in mixed-species biofilms on natural POM. Results will increase knowledge of bacterial community functioning and biofilm recycling of POM in marine environments.Read moreRead less
Geobiological gold cycling: Golden opportunities for the minerals industry. This project aims to develop new geobiological tools for gold exploration and processing that are rooted in a fundamental understanding of geobiological gold cycling. Given the high production costs, the sustainability of the Australian gold industry relies strongly on innovation. Yet, there are many gaps in our fundamental understanding of bio (geo)chemical gold dispersion and precipitation. This project aims to fill th ....Geobiological gold cycling: Golden opportunities for the minerals industry. This project aims to develop new geobiological tools for gold exploration and processing that are rooted in a fundamental understanding of geobiological gold cycling. Given the high production costs, the sustainability of the Australian gold industry relies strongly on innovation. Yet, there are many gaps in our fundamental understanding of bio (geo)chemical gold dispersion and precipitation. This project aims to fill these gaps by linking biochemical pathways of gold mobilisation and resistance in bacteria to its transport and biomineralisation. This would enable the development of protein-based biosensors, bioindicators and nanovectors. These would support the development of exploration and bioaccumulation technologies that allow more economically sustainable and environmentally viable mining practices, such as enhancing production from subeconomic ore.Read moreRead less
Faecal Microbiota Transplantation For Active Ulcerative Colitis - A Randomised Controlled Trial: Clinical, Microbial & Immune Outcomes
Funder
National Health and Medical Research Council
Funding Amount
$700,126.00
Summary
This is a placebo controlled clinical trial to see whether giving healthy donor faeces to people with active ulcerative colitis can get them into remission. We will also examine how long the donor microbiome stays in the recipients stool, and examine the effects of faecal transplantation on the immune response in the lining of the colon in recipients.
Defining New Building Blocks for the Construction of Artificial Genetic Circuits. By characterising the components of a natural genetic switch, we will make available a set of well defined genetic building blocks for construction of rationally designed biological circuits. The ability to build such circuits would have significant economic benefit in areas such as metabolic engineering, to improve the efficiency of production of natural compounds from micro-organisms, and in biomedicine, for the ....Defining New Building Blocks for the Construction of Artificial Genetic Circuits. By characterising the components of a natural genetic switch, we will make available a set of well defined genetic building blocks for construction of rationally designed biological circuits. The ability to build such circuits would have significant economic benefit in areas such as metabolic engineering, to improve the efficiency of production of natural compounds from micro-organisms, and in biomedicine, for the controlled release of therapeutic compounds. The involvement of Honours and Ph.D students in this project will expose the next generation of Australian scientists to this emerging discipline. International collaboration leading to publications in high impact scientific journals will enhance Australia's scientific reputation.Read moreRead less
The geomicrobiology and (bio)geochemistry of platinum, palladium and rhodium. Few economic (Platinum) Pt, (Palladium) Pd or (Rhodium) Rh deposits are known in Australia despite an abundance of potential host rock. By improving onshore exploration techniques this project will ensure the supply of these strategic metals to the Australian economy. By integrating geochemical, molecular microbial and microanalyses (e.g., synchrotron) techniques this project will also: (i) enhance Australia's status i ....The geomicrobiology and (bio)geochemistry of platinum, palladium and rhodium. Few economic (Platinum) Pt, (Palladium) Pd or (Rhodium) Rh deposits are known in Australia despite an abundance of potential host rock. By improving onshore exploration techniques this project will ensure the supply of these strategic metals to the Australian economy. By integrating geochemical, molecular microbial and microanalyses (e.g., synchrotron) techniques this project will also: (i) enhance Australia's status in the breakthrough science of Geomicrobiology; (ii) secure a leading role for Australian science in the assessment of anthropogenic Pt, Pd and Rh pollution; (iii) access expertise developed overseas by fostering international collaborations; and (iv) explore the transformational capabilities of microbiota for ore-processing of and nano-particle production.Read moreRead less
Bacterial mechanisms of gold mobilisation and precipitation with applications to mineral processing and exploration. The development of a comprehensive model for the biogeochemical behaviour of gold in the environment will aid mineral explorers to interpret existing exploration data and to develop better exploration strategies. Moreover, this project aims to develop the basis for a new geomicrobiological gold exploration method by identifying organisms and microbial gene sequences that could be ....Bacterial mechanisms of gold mobilisation and precipitation with applications to mineral processing and exploration. The development of a comprehensive model for the biogeochemical behaviour of gold in the environment will aid mineral explorers to interpret existing exploration data and to develop better exploration strategies. Moreover, this project aims to develop the basis for a new geomicrobiological gold exploration method by identifying organisms and microbial gene sequences that could be used as biomarkers for mineralisation. This research will also provide the fundamental information required to copy nature and engineer new cost-efficient and environmentally friendly technologies for gold processing using microorganisms that occur naturally in Australian soils. Read moreRead less
Synthetic biology tools for integration into bacterial chromosomes. The aim of the project is to develop a set of versatile chromosomal integration tools for bacteria, enabling rapid development of novel biological outputs. A major goal in the emerging discipline of synthetic biology is to apply engineering principles to the design and construction of new biological entities such as proteins, genetic circuits and cells. Custom-designed genetic circuits, integrated in an appropriate host genome, ....Synthetic biology tools for integration into bacterial chromosomes. The aim of the project is to develop a set of versatile chromosomal integration tools for bacteria, enabling rapid development of novel biological outputs. A major goal in the emerging discipline of synthetic biology is to apply engineering principles to the design and construction of new biological entities such as proteins, genetic circuits and cells. Custom-designed genetic circuits, integrated in an appropriate host genome, hold enormous economic potential for applications ranging from biomedicine to biofuel production. This project aims to help synthetic biologists to embed made-to-order circuits in appropriate host cells to act as living factories, potentially replacing industrial processes which are currently environmentally and economically costly.Read moreRead less
Mechanisms and management of inducible tolerance to synthetic insecticides and Bacillus thuringiensis (Bt)-formulations in Australian populations of diamondback moth. Insects have a cunning ability to respond to damaging environments by evolving genetic resistance or mobilising metabolic tolerance mechanisms. Recent observations of inducible tolerance to synthetic and biopesticides, which can be transmitted to offspring by a maternal effect has the potential to cause ecological and economic prob ....Mechanisms and management of inducible tolerance to synthetic insecticides and Bacillus thuringiensis (Bt)-formulations in Australian populations of diamondback moth. Insects have a cunning ability to respond to damaging environments by evolving genetic resistance or mobilising metabolic tolerance mechanisms. Recent observations of inducible tolerance to synthetic and biopesticides, which can be transmitted to offspring by a maternal effect has the potential to cause ecological and economic problems in agricultural production. We will use field-collected Diamondback moth (DBM), a major insect pest in canola and brassica vegetable crops, to investigate the genetic implications of inducible tolerance for the integrated management of DBM and for the design of new resistance management strategies.Read moreRead less
Role of rhizosphere microorganisms in growth of plants in soils with low P availability. The concentration of available phosphorus in many Australian soils is low compared to the requirement of plants and soil organisms. Plant genotypes differ in their capacity to grow at low P availability but the role of rhizosphere microorganisms in plant P uptake from such soils is largely unknown. We will determine the role of rhizosphere microorganisms in P solubilisation and mobilisation in different crop ....Role of rhizosphere microorganisms in growth of plants in soils with low P availability. The concentration of available phosphorus in many Australian soils is low compared to the requirement of plants and soil organisms. Plant genotypes differ in their capacity to grow at low P availability but the role of rhizosphere microorganisms in plant P uptake from such soils is largely unknown. We will determine the role of rhizosphere microorganisms in P solubilisation and mobilisation in different crop genotypes and native plant species in different Australian soils with low P availability. The results will give a comprehensive picture of the role of rhizosphere microbial ecology in phosphorus acquisition by crop and native plants.Read moreRead less