A systems approach to dissect the pathogenicity and host specificity of the Fusarium wilt pathogen, Fusarium oxysporum. The pathogenic fungus Fusarium oxysporum causes wilt disease in many plant species, including many that are important for Australian agriculture. Developing environmentally friendly disease protection strategies against this pathogen requires a clear understanding of infection strategies used by the fungus to invade its host. This project, along with a parallel project in host ....A systems approach to dissect the pathogenicity and host specificity of the Fusarium wilt pathogen, Fusarium oxysporum. The pathogenic fungus Fusarium oxysporum causes wilt disease in many plant species, including many that are important for Australian agriculture. Developing environmentally friendly disease protection strategies against this pathogen requires a clear understanding of infection strategies used by the fungus to invade its host. This project, along with a parallel project in host resistance mechanisms, will provide the basis for development of a world leading platform in mechanisms of fungal pathogenicity and virulence and plant disease resistance/susceptibility. Application of the knowledge gained in this project to other host-pathogen interactions will thereby provide opportunities for improved crop protection and biosecurity.Read moreRead less
Role of mRNA polyadenylation control in gene expression. Several benefits would come from a more complete understanding of the function of the messenger RNA poly(A) tail. It is frequently targeted by mechanisms that control cellular protein synthesis. This is most evident in developmental biology, where tail length control regulates maternal mRNA expression. Our previous work suggests that it has much wider importance for cellular function than previously thought and thus its study will produce ....Role of mRNA polyadenylation control in gene expression. Several benefits would come from a more complete understanding of the function of the messenger RNA poly(A) tail. It is frequently targeted by mechanisms that control cellular protein synthesis. This is most evident in developmental biology, where tail length control regulates maternal mRNA expression. Our previous work suggests that it has much wider importance for cellular function than previously thought and thus its study will produce knowledge of broad relevance to modern life sciences and its applications in medicine and biotechnology. Finally, a better understanding of yeast cellular biology is of benefit to the food and biotechnology sector of industry.Read moreRead less
The evolution and maintenance of specificity, mutualism and diversity in plant-soil microbe interactions. This research will significantly advance knowledge regarding the evolution of mutualisms between plant and soil microbes. Results will provide valuable data on the importance of below-ground microbial community structure to growth and productivity of an ecologically important component of the Australian flora (Acacia spp.), and contribute to the development of best ecosystem restoration prac ....The evolution and maintenance of specificity, mutualism and diversity in plant-soil microbe interactions. This research will significantly advance knowledge regarding the evolution of mutualisms between plant and soil microbes. Results will provide valuable data on the importance of below-ground microbial community structure to growth and productivity of an ecologically important component of the Australian flora (Acacia spp.), and contribute to the development of best ecosystem restoration practices. Furthermore, it will see the continued development of the Acacia-rhizobia system as a world-class model for exploring interactions between perennial legumes and microbial symbionts. The research also investigates the adaptability and potential for rapid evolution of critical elements of the soil microflora to environmental change.Read moreRead less
The ecological dynamics of secreted bacteriocins and the evolution of multiple bacteriocin production in Escherichia coli. Bacteria produce compounds known as bacteriocins that are toxic to other microorganisms. The success of bacteria as bio-control agents and in probiotic formulations for the control microbial pathogens is, in part, due to bacteriocins. Bacteriocins may also have a role as replacements for traditional antibiotics and as natural food preservatives. The potential usefulness of b ....The ecological dynamics of secreted bacteriocins and the evolution of multiple bacteriocin production in Escherichia coli. Bacteria produce compounds known as bacteriocins that are toxic to other microorganisms. The success of bacteria as bio-control agents and in probiotic formulations for the control microbial pathogens is, in part, due to bacteriocins. Bacteriocins may also have a role as replacements for traditional antibiotics and as natural food preservatives. The potential usefulness of bacteriocins as the active agent in bio-control agents, as antibiotic replacements, as food preservatives, and as part of the repertoire of traits in probiotic formulations requires a sound understanding of the eco-evolutionary dynamics of bacteriocins. Understanding the ecology and evolution of bacteriocins is the goal of the proposed research.Read moreRead less
ARC Centre of Excellence - Structural and Functional Microbial Genomics. The research falls under the National Research Priority Frontier Technologies for Building and Transforming Australian Industries, with the priority goal of frontier technologies. The research has commercial applications, such as the development of novel antimicrobials and vaccines, with potentially enormous impact in the biotechnology area of biomedical health and the primary industries. In addition, the project will use ....ARC Centre of Excellence - Structural and Functional Microbial Genomics. The research falls under the National Research Priority Frontier Technologies for Building and Transforming Australian Industries, with the priority goal of frontier technologies. The research has commercial applications, such as the development of novel antimicrobials and vaccines, with potentially enormous impact in the biotechnology area of biomedical health and the primary industries. In addition, the project will use state-of-the-art technology, including use of synchrotron radiation at the Monash-based Australian Synchrotron facility from 2007.Read moreRead less
ARC Centre for Structural & Functional Microbial Genomics. Australian Primary Industry will benefit from a team of experts in microbial genetics, bioinformatics and protein structure and function undertaking integrated studies on microbial genomics and phenomics that are focused on fundamental biological processes and host/pathogen interactions. Whole genome expression and protein profiling will be used to characterise genes whose expression is altered in the infected host and to analyse genes i ....ARC Centre for Structural & Functional Microbial Genomics. Australian Primary Industry will benefit from a team of experts in microbial genetics, bioinformatics and protein structure and function undertaking integrated studies on microbial genomics and phenomics that are focused on fundamental biological processes and host/pathogen interactions. Whole genome expression and protein profiling will be used to characterise genes whose expression is altered in the infected host and to analyse genes involved in the control of key cellular processes. The Centre will also determine the shapes of key molecules and their interactions. Practical outcomes will include new veterinary vaccines and the identification of novel antimicrobial targets.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE180100046
Funder
Australian Research Council
Funding Amount
$365,058.00
Summary
Capturing highly beneficial and persistent legume symbionts. This project aims to investigate impacts of climate change on the survival of symbiotic soil bacteria and the nutritional benefits they provide plants, using molecular technology. This project will generate new knowledge about the process of adaptation in symbiotic bacteria, by measuring genomic changes. Expected outcomes of this project include enhanced capacity to design ecological or genetic manipulations of soil bacteria to augment ....Capturing highly beneficial and persistent legume symbionts. This project aims to investigate impacts of climate change on the survival of symbiotic soil bacteria and the nutritional benefits they provide plants, using molecular technology. This project will generate new knowledge about the process of adaptation in symbiotic bacteria, by measuring genomic changes. Expected outcomes of this project include enhanced capacity to design ecological or genetic manipulations of soil bacteria to augment plant survival and health. Anticipated benefits include enhanced woodland restoration in a biodiversity hotspot, options to mitigate habitat damage from climate change, and strategies to increase agricultural productivity with less fertiliser.Read moreRead less
The Relationship Between Maternal And Infant Dietary Intake Of Fermentable Fibre, Gut Microbiota, Short Chain Fatty Acids And Allergic Disease And Asthma: A Population-derived Birth Cohort Study
Funder
National Health and Medical Research Council
Funding Amount
$871,700.00
Summary
The proposed study will involve the Barwon Infant Study (BIS) cohort of 1074 infants to provide the first systematic investigation of the hypotheses that the epidemic of allergic disease and asthma in many parts of the world relates to the paucity of fermentable fibre in the modern diet, and that the protective effect of fermentable fibre is mediated by changes in the organisms that colonise the gut and the metabolites that they produce.
E. coli as an indicator of faecal contamination in the Australian context. The goal of this research is to improve our ability to use Escherichia coli as an indicator of water quality by determining the extent to which non-faecal sources of E. coli contribute to coliform counts and to develop a method to differentiate non-faecal E. coli from those that are faecal derived.
Biogeochemistry of ferruginous duricrusts. The project is focussed on the examination and application of microbial iron cycling in the formation of geologically stable, iron duricrusts in tropical regimes. The aim of the project is to develop a site-scale bioremediation strategy for iron ore mines by re-establishing canga, which are ‘ancient’ distinct ecosystems possessing unique plant species rarely found on Earth. This university-industry collaboration aims to produce economic benefits for the ....Biogeochemistry of ferruginous duricrusts. The project is focussed on the examination and application of microbial iron cycling in the formation of geologically stable, iron duricrusts in tropical regimes. The aim of the project is to develop a site-scale bioremediation strategy for iron ore mines by re-establishing canga, which are ‘ancient’ distinct ecosystems possessing unique plant species rarely found on Earth. This university-industry collaboration aims to produce economic benefits for the world’s iron mining industry through advanced training in mining-related research, and through the completion of the mining life cycle by site remediation, enhancing Australia’s position as a global leader in providing innovative solutions to today’s mining challenges.Read moreRead less