The evolution of diverse interactions between Wolbachia bacteria and their invertebrate hosts: insights from a novel lineage infecting termite societies. Wolbachia intracellular bacteria are widespread in invertebrates, having evolved a remarkable range of host-interactions, from parasitic to mutualistic. I have discovered phylogenetically novel Wolbachia that infect the structural pests termites, and will investigate their host-effects and transmission dynamics. This will determine the generali ....The evolution of diverse interactions between Wolbachia bacteria and their invertebrate hosts: insights from a novel lineage infecting termite societies. Wolbachia intracellular bacteria are widespread in invertebrates, having evolved a remarkable range of host-interactions, from parasitic to mutualistic. I have discovered phylogenetically novel Wolbachia that infect the structural pests termites, and will investigate their host-effects and transmission dynamics. This will determine the generality of phenomena known from other Wolbachia, such as cytoplasmic incompatibility and horizontal transfer. The complexity of termite societies make them interesting candidates for studying how Wolbachia spread, and the results will be potentially valuable for future termite control strategies. The first comparative phylogenetic examination of diverse Wolbachia will be performed, providing new perspectives on their evolutionary history.Read moreRead less
How do Microbes Grow in High Salt at Very Cold Temperatures. The proposed research aims to define mechanisms of survival and speciation that underpin the capacity of a novel group of Antarctic microorganisms to evolve dominance in their very cold (-20 degrees Celsius) and very salty environment. Most (~85 per cent) of the Earth's biosphere is cold (<5 degrees Celsius), and yet contains a rich diversity of microorganisms of which we know little. The uniqueness and sensitivity of Antarctica partic ....How do Microbes Grow in High Salt at Very Cold Temperatures. The proposed research aims to define mechanisms of survival and speciation that underpin the capacity of a novel group of Antarctic microorganisms to evolve dominance in their very cold (-20 degrees Celsius) and very salty environment. Most (~85 per cent) of the Earth's biosphere is cold (<5 degrees Celsius), and yet contains a rich diversity of microorganisms of which we know little. The uniqueness and sensitivity of Antarctica particularly demands that we rapidly improve our understanding of its biology. The discoveries made could provide fundamental insight about speciation - processes controlling which life forms that colonise the planet.Read moreRead less
Integrating nutritional immunology. What an organism eats affects both its susceptibility to disease and the community of beneficial microorganisms living within its gut. This project will study how nutrition, immunity and the flora of the gut interact, and whether hosts are able to select a diet that optimises their immune response and gut flora in the face of disease challenges.
Altering host-parasite interactions through wildlife conservation strategies. Disease outbreaks are heightened in endangered animals but strategies used to conserve these species often increase risk of disease; nowhere is this more critical than in species recovery programs. The project will study disease in a recovery program to improve conservation practice and protect Australia's wildlife, ensuring our ecosystems are sustained.
Skin Microbes and Animal Health: Understanding the Ecological Context. This project aims to understand the fundamental ecological relationships between animal hosts (frogs, geckos) and bacteria on their skin by separating host effects from environmental factors that determine skin microbiome composition. The research is significant because it will generate new knowledge needed to understand how skin microbes function in providing protection against disease. Expected outcomes include the provisio ....Skin Microbes and Animal Health: Understanding the Ecological Context. This project aims to understand the fundamental ecological relationships between animal hosts (frogs, geckos) and bacteria on their skin by separating host effects from environmental factors that determine skin microbiome composition. The research is significant because it will generate new knowledge needed to understand how skin microbes function in providing protection against disease. Expected outcomes include the provision of essential information that will guide future research efforts on the factors that determine a healthy skin microbial community (which is needed before skin diseases can be combated). The research will provide significant benefits, including more targeted conservation efforts to combat wildlife skin diseases.Read moreRead less
Expanding gene-environment causality in evolutionary genetics. This project aims to investigate how environmental experiences shape phenotypes, engender variance in populations and ultimately contribute to evolution. It targets new discoveries for how environmental effects can multiply throughout ontogeny and/or propagate across generations. Although widely speculated to support new evolutionary paradigms, such knowledge lacks scrutiny according to the formal metric of quantitative genetics. Thi ....Expanding gene-environment causality in evolutionary genetics. This project aims to investigate how environmental experiences shape phenotypes, engender variance in populations and ultimately contribute to evolution. It targets new discoveries for how environmental effects can multiply throughout ontogeny and/or propagate across generations. Although widely speculated to support new evolutionary paradigms, such knowledge lacks scrutiny according to the formal metric of quantitative genetics. This project seeks to expose guppy pedigrees to unique manipulations and reconcile adaptive evolution across captive and wild populations. The outcome is expected to address knowledge gaps in the life and human sciences and potentially inform goals in primary production and conservation.Read moreRead less
Intergenomic conflict and the evolution of uniparental inheritance of mitochondria. Why do all mammalian male sperm cells destroy their own mitochondria after fertilisation? A major evolutionary theory, the conflict hypothesis, aims to answer this question. The argument goes as follows. If an organism were to contain mitochondria from both parents, each mitochondrial lineage would be selected in an “arms race” to replicate faster than the other lineage, and this would likely be costly to the org ....Intergenomic conflict and the evolution of uniparental inheritance of mitochondria. Why do all mammalian male sperm cells destroy their own mitochondria after fertilisation? A major evolutionary theory, the conflict hypothesis, aims to answer this question. The argument goes as follows. If an organism were to contain mitochondria from both parents, each mitochondrial lineage would be selected in an “arms race” to replicate faster than the other lineage, and this would likely be costly to the organism. Uniparental inheritance of mitochondria prevents such evolutionary arms race. Sounds plausible? Yes. Has it been tested? No. This project will be the first attempt to test this intriguing hypothesis. Experimental evidence for the evolution of selfish mitochondria would provide solid support for this major evolutionary theory. Read moreRead less
Lamarckian lizards: novel integration of telomere epigenetics, free radicals and innate antioxidants in condition-dependant sexual signal evolution. In 2009, the Nobel Prize in physiology was awarded Drs. Blackburn, Greider and Szostak for discoveries on telomeres. This project will investigate how telomeres not only cap chromosomes from destruction by free radicals, but also have a key role in life itself, in their influence on ageing, longevity, ornaments and lifetime reproductive success.
Understanding how reproduction and sexual conflict drive sex-dependent longevity and ageing. The biological study of longevity and ageing has two important fronts: understanding how evolution shapes lifespan and ageing, and the mechanistic study of how molecules, genes, hormones, tissues and cells interact during ageing. The evolutionary study of ageing is considered one of the success stories of the emerging field of evolutionary medicine, yet we desperately need greater integration of the evol ....Understanding how reproduction and sexual conflict drive sex-dependent longevity and ageing. The biological study of longevity and ageing has two important fronts: understanding how evolution shapes lifespan and ageing, and the mechanistic study of how molecules, genes, hormones, tissues and cells interact during ageing. The evolutionary study of ageing is considered one of the success stories of the emerging field of evolutionary medicine, yet we desperately need greater integration of the evolutionary and mechanistic spheres. This project addresses why males and females have different lifespans and age differently in a way that bridges evolutionary and mechanistic study, and will build Australia's research capacity to study ageing at both levels. Read moreRead less
The role of genome reorganisation in adaptation and speciation. Local adaptation and speciation are fundamental evolutionary processes that rely on changes to the genome. However, the role of genome architecture (e.g. chromosomal rearrangements, gene duplications) in driving these processes is poorly understood. This project will use advanced comparative genomics and bioinformatics to examine the role of chromosome rearrangements in driving adaptation and speciation, and evaluate rates of molec ....The role of genome reorganisation in adaptation and speciation. Local adaptation and speciation are fundamental evolutionary processes that rely on changes to the genome. However, the role of genome architecture (e.g. chromosomal rearrangements, gene duplications) in driving these processes is poorly understood. This project will use advanced comparative genomics and bioinformatics to examine the role of chromosome rearrangements in driving adaptation and speciation, and evaluate rates of molecular evolution between the X-chromosome and autosomes. Utilising Australia’s endemic mammalian fauna as a tractable model system, I will link population processes with macro-evolutionary outcomes to show how genome architecture underpins biodiversity.Read moreRead less