Linkage Infrastructure, Equipment And Facilities - Grant ID: LE140100114
Funder
Australian Research Council
Funding Amount
$560,000.00
Summary
High Throughput Cell Genomics Centre. High throughput cell genomics centre: This project will establish a high throughput cell genomics centre comprising a Fluidigm C1™ Single-Cell AutoPrep and BioMark™ HD system providing researchers with the most innovative approach to single cell and small population analyses. The instruments will enable the unique capability to conduct single cell transcriptome analysis and high throughput gene expression, SNP genotyping and copy number variation analysis as ....High Throughput Cell Genomics Centre. High throughput cell genomics centre: This project will establish a high throughput cell genomics centre comprising a Fluidigm C1™ Single-Cell AutoPrep and BioMark™ HD system providing researchers with the most innovative approach to single cell and small population analyses. The instruments will enable the unique capability to conduct single cell transcriptome analysis and high throughput gene expression, SNP genotyping and copy number variation analysis as well as validation of next generation sequencing data. The information generated is crucial to advancing knowledge in important research fields including infection and immunity, regenerative medicine, immune responses, biomarker discovery, drug discovery, biotechnology and agriculture.Read moreRead less
Pathogenesis Of Persistent Human Virus Infections Of Global Significance
Funder
National Health and Medical Research Council
Funding Amount
$6,571,328.00
Summary
The study will investigate why humans cannot eradicate particular viruses (HIV-AIDS, cytomegalovirus and herpes simplex virus), the long term effects of these viruses and ways to improve control. Current treatments can only partly suppress the levels of these viruses, because they persist in certain parts of the body called reservoirs, only to resurge later causing disease. Thus, the overall aim of the research program is to discover the mechanisms by which these viruses are able to successfully ....The study will investigate why humans cannot eradicate particular viruses (HIV-AIDS, cytomegalovirus and herpes simplex virus), the long term effects of these viruses and ways to improve control. Current treatments can only partly suppress the levels of these viruses, because they persist in certain parts of the body called reservoirs, only to resurge later causing disease. Thus, the overall aim of the research program is to discover the mechanisms by which these viruses are able to successfully persist within reservoirs in the human body. The research program brings together a group of 6 leading scientists and clinicians located at 3 sites in 2 Australian cities. The team is comprised of experts in the study of HIV-AIDS, cytomegalovirus and herpes simplex virus who will combine their knowledge and expertise to speed up the process of research on these viruses that are of major health importance. Studies will also utilise a number of cutting edge technologies that now make it possible to much more rapidly and precisely determine how viruses cause disease. Advances in our understanding of how viruses persist may form the basis for treatments aimed at controlling persistent infections and the serious diseases caused by these viruses.Read moreRead less
Targeting Drug-Resistance In Paediatric Acute Lymphoblastic Leukaemia
Funder
National Health and Medical Research Council
Funding Amount
$649,048.00
Summary
Leukaemia is the most common type of cancer in children but resistance to therapy continues to be a significant problem. This project will investigate the biology of drug-resistance and relapse using a mouse model that replicates the human disease. We hope to identify novel therapeutic targets that can be used in combination with existing therapies to improve outcomes in this disease, particularly for patients that develop drug-resistance such as those at the time of relapse.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0453561
Funder
Australian Research Council
Funding Amount
$336,706.00
Summary
Integrated Precision Machining of Complex Profiles. High precision and high speed machining is of central importance to the development of a wide range of frontier technologies such as precision manufacturing, nano-materials fabrication, semiconductor and composite processing, vehicle production and steel structure manufacturing. The research significance has been well established by the world-leading projects and achievements. The proposed facility has distinct features and capability of high l ....Integrated Precision Machining of Complex Profiles. High precision and high speed machining is of central importance to the development of a wide range of frontier technologies such as precision manufacturing, nano-materials fabrication, semiconductor and composite processing, vehicle production and steel structure manufacturing. The research significance has been well established by the world-leading projects and achievements. The proposed facility has distinct features and capability of high loop-stiffness, high repeatability, universal profiling, organic integration of key machining operations, and great flexibility of both low and high speeds. These unique characteristics will enable the innovative development of many research programs which will otherwise be impossible to achieve.Read moreRead less
High-Performance Microwave and Millimetre Wave Antennae Based on Multi-layer Periodic Structures. Broadband communication has created a rapidly growing market for innovative microwave communication systems such as WiFi and WiMAX. Millimetre-wave technology is expected to deliver the next leap in communication technology with much faster wireless links for 3D TV etc. By developing innovative, low-cost, planar antennas with high performance, the proposed research will create opportunities for Aust ....High-Performance Microwave and Millimetre Wave Antennae Based on Multi-layer Periodic Structures. Broadband communication has created a rapidly growing market for innovative microwave communication systems such as WiFi and WiMAX. Millimetre-wave technology is expected to deliver the next leap in communication technology with much faster wireless links for 3D TV etc. By developing innovative, low-cost, planar antennas with high performance, the proposed research will create opportunities for Australian industry to compete in this growing global market with advanced, cost-effective, microwave and millimetre-wave products. The Australian research community will benefit from new methods, techniques and trained researchers, while Australian consumers will benefit from improved quality and low cost of services.Read moreRead less
Hybrid-resonator antennas for wireless communication networks. The rapid emergence of modern wireless communication systems has led to a requirement for small, lightweight antennas. In this project, a new, broadband, low-cost, small and lightweight antenna architecture will be developed for wireless systems. The new architecture is based on a novel hybrid-resonator concept: a dielectric resonator tightly coupled to a metal patch resonator. The rapid design and optimisation of new antennas will b ....Hybrid-resonator antennas for wireless communication networks. The rapid emergence of modern wireless communication systems has led to a requirement for small, lightweight antennas. In this project, a new, broadband, low-cost, small and lightweight antenna architecture will be developed for wireless systems. The new architecture is based on a novel hybrid-resonator concept: a dielectric resonator tightly coupled to a metal patch resonator. The rapid design and optimisation of new antennas will be achieved by developing several new theoretical methods. Antennas targeted for the Unlicensed National Information Infrastructure (UNII) band (5-6 GHz) commercial wireless communication systems will be designed, fabricated, tested and integrated with the systems.
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Integration of Wireless LAN and GPRS/UMTS Cellular Systems. Integration of wireless local area networks with cellular mobile systems provides a feasible, reliable, and cost-effective way for high-speed mobile Internet access in wide area networks. In this project in collaboration with Australia's second largest telecommunications company; Optus, we will develop network architecture and essential access and mobility techniques for such a system. The project's outcomes will enable Optus to expand ....Integration of Wireless LAN and GPRS/UMTS Cellular Systems. Integration of wireless local area networks with cellular mobile systems provides a feasible, reliable, and cost-effective way for high-speed mobile Internet access in wide area networks. In this project in collaboration with Australia's second largest telecommunications company; Optus, we will develop network architecture and essential access and mobility techniques for such a system. The project's outcomes will enable Optus to expand its broadband mobile Internet service to all parts and population of the country including rural and regional areas and subsequently export the breakthrough technology resulted from the project to overseas.Read moreRead less
Broadband and Multiband Antenna Systems. Wireless communication has become essential in the modern information society and this has created a rapidly growing, multi-billion dollar market for innovative wireless products. Australia has a strong potential to gain from this market, as demonstrated by world-leading products, e.g. wireless computer microchips. By developing innovative antenna systems with new capabilities, the proposed research will create opportunities for Australian industry to com ....Broadband and Multiband Antenna Systems. Wireless communication has become essential in the modern information society and this has created a rapidly growing, multi-billion dollar market for innovative wireless products. Australia has a strong potential to gain from this market, as demonstrated by world-leading products, e.g. wireless computer microchips. By developing innovative antenna systems with new capabilities, the proposed research will create opportunities for Australian industry to compete in the global wireless market with advanced, low-cost, high-performance, and universal products. The Australian research community will benefit from new theoretical techniques and trained researchers, while wireless users will benefit from improved quality and low cost of services.Read moreRead less
Understanding protein-nucleic-acid interaction networks in cold-adapted archaea. The aim of this project is to learn how microorganisms can function effectively in naturally cold environments. Results will determine how important cellular processes occur when microorganisms grow in the cold, and hence why they are able to maintain a natural balance in ecosystems such as Antarctica.
Genetic variation of single cell transcriptional heterogeneity in HiPSCs. This project aims to investigate whether induced pluripotent stem cells (iPSC) can be used to study the functions of genetic variants associated with human phenotypes and cell fate decisions. The project will utilise technology to produce single cell RNA sequence data for 100,000s of cells. By sequencing individual cells, the genetic control of cellular heterogeneity both within and between cells can be identified, and in ....Genetic variation of single cell transcriptional heterogeneity in HiPSCs. This project aims to investigate whether induced pluripotent stem cells (iPSC) can be used to study the functions of genetic variants associated with human phenotypes and cell fate decisions. The project will utilise technology to produce single cell RNA sequence data for 100,000s of cells. By sequencing individual cells, the genetic control of cellular heterogeneity both within and between cells can be identified, and in doing so, will provide significant benefit by revealing the potential for iPSC to be used for functional translation of human genomics.Read moreRead less