Improving the efficiency of CRISPR gene editing in cells. Human red blood cells are well-characterised and the globin gene locus is a model system for the study of gene regulation. Gene editing technologies and delivery tools are evolving rapidly and the globin gene locus is the perfect model for gene editing optimisation. This collaboration between UNSW Sydney and CSL aims to bring together our combined expertise and new technologies to develop an optimal platform for genetic modification in a ....Improving the efficiency of CRISPR gene editing in cells. Human red blood cells are well-characterised and the globin gene locus is a model system for the study of gene regulation. Gene editing technologies and delivery tools are evolving rapidly and the globin gene locus is the perfect model for gene editing optimisation. This collaboration between UNSW Sydney and CSL aims to bring together our combined expertise and new technologies to develop an optimal platform for genetic modification in a red blood cell line. Simultaneously, this project aims to generate fundamental insights into mechanisms of human gene regulation. The technological and biological outcomes of this project will be of benefit for future gene editing applications.Read moreRead less
Elastic and biodegradable sponges/aerogels from exfoliated silk nanofibres . The aim of this project is to investigate methods to produce highly porous elastic sponges from silk protein nanofibres. These sponges will have optimal mechanical, insulation and degradation properties making them suitable for a wide range of applications including the biomedical and personal care sectors, where current products have significant drawbacks due to the use of non-biodegradable synthetic materials. Outco ....Elastic and biodegradable sponges/aerogels from exfoliated silk nanofibres . The aim of this project is to investigate methods to produce highly porous elastic sponges from silk protein nanofibres. These sponges will have optimal mechanical, insulation and degradation properties making them suitable for a wide range of applications including the biomedical and personal care sectors, where current products have significant drawbacks due to the use of non-biodegradable synthetic materials. Outcomes include new knowledge on controlling porous structures and tailoring properties to targeted applications. This project, by laying the groundwork for a new generation of bio-based materials, will benefit the Australian advanced manufacturing sector, and enhance Australia's standing in materials science and engineering.Read moreRead less
Investigations into the antibacterial mechanism of action of cannabidiol. This project aims to understand how the compound cannabidiol is able to kill bacteria by examining its interactions with bacteria from a genetic and molecular level. This research is critical, because future development of cannabidiol and design of improved analogs is predicated on knowing how it works. Expected outcomes include the first detailed understanding of how cannabidiol interacts with bacteria. This should lead ....Investigations into the antibacterial mechanism of action of cannabidiol. This project aims to understand how the compound cannabidiol is able to kill bacteria by examining its interactions with bacteria from a genetic and molecular level. This research is critical, because future development of cannabidiol and design of improved analogs is predicated on knowing how it works. Expected outcomes include the first detailed understanding of how cannabidiol interacts with bacteria. This should lead to significant benefits, including high impact publications, additional collaborations with industrial partner Botanix, and a new class of antibiotics to overcome antibiotic resistance.Read moreRead less
Developing an integrated device for on-farm detection of sugarcane diseases. Pathogenic organisms cause yield losses of more than $150M pa to the Australian sugarcane industry and many millions more worldwide. Partnering with Sugar Research Australia, this project aims to develop a novel on-farm diagnostic device, comprising new nanotechnology and magnetism-induced microfluidics with naked eye observation and electrochemical detection. This device is expected to enable improved disease managemen ....Developing an integrated device for on-farm detection of sugarcane diseases. Pathogenic organisms cause yield losses of more than $150M pa to the Australian sugarcane industry and many millions more worldwide. Partnering with Sugar Research Australia, this project aims to develop a novel on-farm diagnostic device, comprising new nanotechnology and magnetism-induced microfluidics with naked eye observation and electrochemical detection. This device is expected to enable improved disease management strategies through the prediction of potential risks and rapid and effective actions to mitigate impending yield loss. In turn productivity and sustainability of Australia’s sugar industry will be enhanced. The new platform device has great potential for improved disease management in other crops in Australia and globally.Read moreRead less
Coordinating Innovation in Knowledge-Based Multinational Organisations. Integration into global supply chains is one of the fundamental challenges for manufacturing companies in Australia. This project seeks to identify the optimal design for coordinating innovation in globally-dispersed organisations. It will analyse three mechanisms for transferring knowledge within organisations: hierarchies, communities of practice, and social networks. Outcomes will include a new multilevel statistical netw ....Coordinating Innovation in Knowledge-Based Multinational Organisations. Integration into global supply chains is one of the fundamental challenges for manufacturing companies in Australia. This project seeks to identify the optimal design for coordinating innovation in globally-dispersed organisations. It will analyse three mechanisms for transferring knowledge within organisations: hierarchies, communities of practice, and social networks. Outcomes will include a new multilevel statistical network modelling framework and organisational designs to overcome barriers to knowledge-transfer, such as language, culture and distance. The project will collect and apply data from Boeing Global Technology, the international research arm of The Boeing Company, a world leading business with major subsidiaries in Australia.Read moreRead less
Enabling Disability? Autonomous Technologies & CaLD persons with disability. Over 1 million disabled Australians are from culturally and linguistically diverse (CaLD) communities, the majority of whom are ineligible for disability and multicultural services. CaLD persons with disability significantly rely on digital information systems, devices and platforms to secure their economic, social and cultural inclusion. Evidence to date documents the continual exclusionary impact of artificial intelli ....Enabling Disability? Autonomous Technologies & CaLD persons with disability. Over 1 million disabled Australians are from culturally and linguistically diverse (CaLD) communities, the majority of whom are ineligible for disability and multicultural services. CaLD persons with disability significantly rely on digital information systems, devices and platforms to secure their economic, social and cultural inclusion. Evidence to date documents the continual exclusionary impact of artificial intelligence (AI) behind such technologies in addition to its inaccessibility to complex end-users. Yet, AI is now central to socio-economic well being and inclusion. In partnership with community and industry, this project will inform future AI developments and policy increasing its adaptability, accessibility and affordability.
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Making eMaking Accessible for People with Intellectual Disabilities. This interdisciplinary research will create an evidence based eMaking program that empowers people with Intellectual Disabilities. eMaking benefits include collaborative problem solving and employment pathways; however, people with disabilities are often excluded. Through a unique, inclusive, outreach van, strategies to build accessible eMaking will be generated. Project outcomes include replicable, scalable eMaking activities ....Making eMaking Accessible for People with Intellectual Disabilities. This interdisciplinary research will create an evidence based eMaking program that empowers people with Intellectual Disabilities. eMaking benefits include collaborative problem solving and employment pathways; however, people with disabilities are often excluded. Through a unique, inclusive, outreach van, strategies to build accessible eMaking will be generated. Project outcomes include replicable, scalable eMaking activities and toolkits to facilitate Science, Technology, Engineering and Mathematics for all. Project benefits include opportunities for people with Intellectual Disability to participate in meaningful recreational or work-focused eMaking, and changing community attitudes through shared eMaking participation.Read moreRead less
Development of drought tolerant, high protein legume for arid Australia. The aim of this research is to demonstrate the molecular basis of a non-proteinogenic amino acid toxin accumulation by using genomics and genome editing to produce a non-transgenic, protein rich legume. The significance of the outcomes will be a fundamental understanding of how non-proteinogenic amino acids are metabolised in plants and an inexpensive, high-protein feed for the pork and chicken industries thereby reducing p ....Development of drought tolerant, high protein legume for arid Australia. The aim of this research is to demonstrate the molecular basis of a non-proteinogenic amino acid toxin accumulation by using genomics and genome editing to produce a non-transgenic, protein rich legume. The significance of the outcomes will be a fundamental understanding of how non-proteinogenic amino acids are metabolised in plants and an inexpensive, high-protein feed for the pork and chicken industries thereby reducing production costs and increasing profitability. The outcomes from the research are fundamental knowledge of non-proteinogenic amino acid metabolism and turnkey approach to identify, engineer, test and produce value added crops. The benefits of the research are a multi-purpose crop for Australian crop and animal producers.Read moreRead less
Low-Cost Multiple Pencil-Beam Lens Antenna System. The project aims to develop a new multiple pencil beam antenna system, taking advantage of CIs' preliminary inventions in lens antennas, 3D printed antennas and arrays, and antenna feeding networks. A dual-polarised antenna array architecture will enhance the sensing quality and resolution of our partner organisation's cleaning robot. It will enable the robot to recognise human presence and movement in low-light conditions for rapid and safe dis ....Low-Cost Multiple Pencil-Beam Lens Antenna System. The project aims to develop a new multiple pencil beam antenna system, taking advantage of CIs' preliminary inventions in lens antennas, 3D printed antennas and arrays, and antenna feeding networks. A dual-polarised antenna array architecture will enhance the sensing quality and resolution of our partner organisation's cleaning robot. It will enable the robot to recognise human presence and movement in low-light conditions for rapid and safe disinfection of public spaces. The project will have an immediate socio-economic impact on local businesses and communities. The outcomes of the project will create safer public environments for people living and working in Australia, and boost economic recovery in the post-pandemic period.Read moreRead less
Multilayered Safety Clothing for Personal Protective Equipment. This project aims to improve multilayered firefighting protective garments and their thermal comfort by utilizing aerogel microparticles containing thermal regulation materials and flame-retardant agents. This research will create new multifunctional fabric designs and engineering techniques to integrate improved heat and flame protection, comfort and smart features into optimized multilayered garments. It will create novel clothing ....Multilayered Safety Clothing for Personal Protective Equipment. This project aims to improve multilayered firefighting protective garments and their thermal comfort by utilizing aerogel microparticles containing thermal regulation materials and flame-retardant agents. This research will create new multifunctional fabric designs and engineering techniques to integrate improved heat and flame protection, comfort and smart features into optimized multilayered garments. It will create novel clothing systems that will better protect wearers and allow them to effectively combat bushfires and save lives and assets. The successful completion will enable industrial capability in next generation advanced protective garments and functional uniforms for broad occupational health safety and well-being applications.Read moreRead less