Improving the efficiency of CRISPR gene editing in cells. Human red blood cells are well-characterised and the globin gene locus is a model system for the study of gene regulation. Gene editing technologies and delivery tools are evolving rapidly and the globin gene locus is the perfect model for gene editing optimisation. This collaboration between UNSW Sydney and CSL aims to bring together our combined expertise and new technologies to develop an optimal platform for genetic modification in a ....Improving the efficiency of CRISPR gene editing in cells. Human red blood cells are well-characterised and the globin gene locus is a model system for the study of gene regulation. Gene editing technologies and delivery tools are evolving rapidly and the globin gene locus is the perfect model for gene editing optimisation. This collaboration between UNSW Sydney and CSL aims to bring together our combined expertise and new technologies to develop an optimal platform for genetic modification in a red blood cell line. Simultaneously, this project aims to generate fundamental insights into mechanisms of human gene regulation. The technological and biological outcomes of this project will be of benefit for future gene editing applications.Read moreRead less
Multimodal retinal imaging provides "insight" into cerebrovascular ageing. Multimodal retinal imaging provides "insight" into cerebrovascular ageing. This project aims to develop a multi-modal imaging technology platform to simultaneously measure amyloid beta and its neurovascular sequelae to identify novel early biomarkers of ageing in the eye and brain. The growing ageing population is an increasing socioeconomic burden. The central nervous system is particularly susceptible to ageing, which i ....Multimodal retinal imaging provides "insight" into cerebrovascular ageing. Multimodal retinal imaging provides "insight" into cerebrovascular ageing. This project aims to develop a multi-modal imaging technology platform to simultaneously measure amyloid beta and its neurovascular sequelae to identify novel early biomarkers of ageing in the eye and brain. The growing ageing population is an increasing socioeconomic burden. The central nervous system is particularly susceptible to ageing, which is difficult to measure at its onset. Critically, as the eye is an easily accessible extension of the cortex, retinal imaging may be a non-invasive surrogate to assess ageing changes in the brain. Anticipated outcomes are a sensitive detector of neural ageing, improved preventative measures, reducing the socioeconomic burden of ageing, and improved quality of life.Read moreRead less
Combined optical and electrical stimulation of auditory neurons. The bionic ear, which has now helped to improve the hearing of over 200,000 people worldwide, is a great example of Australian innovation success. This project aims to develop the fundamental technology that will underpin the next generation of these devices using a combination of infrared light and electrical signals to stimulate auditory nerves.
An Integrated Systems Analysis: Fire Growth and Severity in Enclosures. An integrated systems risk-based model for fire safety has been developed and has been internationally acclaimed. A new fire severity submodel urgently needs to be developed before ramifications of the World Trade Centre catastrophe impact on fire safety regulations. Current submodels seriously misrepresent the real fires. They were developed from 1970's experiments on 2-3 metre cube-like enclosures and predict that fires ....An Integrated Systems Analysis: Fire Growth and Severity in Enclosures. An integrated systems risk-based model for fire safety has been developed and has been internationally acclaimed. A new fire severity submodel urgently needs to be developed before ramifications of the World Trade Centre catastrophe impact on fire safety regulations. Current submodels seriously misrepresent the real fires. They were developed from 1970's experiments on 2-3 metre cube-like enclosures and predict that fires engulf enclosures. Recent preliminary experiments have revealed that real fires burn locally at windows and only appear to be all engulfing. The research will lead international collaboration involving extensive experiments and some modelling to be completed in twelve months.Read moreRead less
Improving patient health outcomes in acute care hospital settings using mobile wireless technology and handheld computers. This project will investigate the use of wireless handheld computers, in three acute care clinical units located at Southern Health and the Royal Women's Hospital, to determine the impact on patient safety and quality of care. There is a need for real time point-of-care access (and input) to patient information, nursing reference information, and drug information for nurses ....Improving patient health outcomes in acute care hospital settings using mobile wireless technology and handheld computers. This project will investigate the use of wireless handheld computers, in three acute care clinical units located at Southern Health and the Royal Women's Hospital, to determine the impact on patient safety and quality of care. There is a need for real time point-of-care access (and input) to patient information, nursing reference information, and drug information for nurses in Australian hospitals. This project aims to address this need by providing nurses with wireless handheld access to such resources. This project is extremely significant, as the outcomes will provide nurses, in Australia and overseas, a set of guidelines for managing wireless handheld computers in clinical units, to enhance patient safety and quality of care.Read moreRead less
Advancing digital inclusion in low income Australian families. This ethnographic investigation explores the complex relationship between digital and social inclusion, and social infrastructure's role (education facilities, charities, government services) in supporting low-income families' social and economic participation. It gathers insights from families in six diverse communities from Far North Queensland to Tasmania, across diverse urban, regional and rural locations. It focuses on the digit ....Advancing digital inclusion in low income Australian families. This ethnographic investigation explores the complex relationship between digital and social inclusion, and social infrastructure's role (education facilities, charities, government services) in supporting low-income families' social and economic participation. It gathers insights from families in six diverse communities from Far North Queensland to Tasmania, across diverse urban, regional and rural locations. It focuses on the digital inclusion implications of children's home and school learning experiences, school leavers' transitions into work, and parenting in digital times. The project is a collaboration with Australia's leading digital inclusion organisations and will develop new practices, policies and sector wide solutions.Read moreRead less
Wideband Silicon-Based Radio-Frequency Front-End Module for 5G New Radio . The project aims to advance knowledge in radio-frequency integrated circuit design in low-cost silicon technologies, particularly power amplifiers design with enhanced energy efficiency at output power back-off levels. The intended outcome of this project will be a wideband RF front-end module with beam steering capability that can cover the 24-50 GHz spectrum band. This will ultimately enable the creation of a low-cost a ....Wideband Silicon-Based Radio-Frequency Front-End Module for 5G New Radio . The project aims to advance knowledge in radio-frequency integrated circuit design in low-cost silicon technologies, particularly power amplifiers design with enhanced energy efficiency at output power back-off levels. The intended outcome of this project will be a wideband RF front-end module with beam steering capability that can cover the 24-50 GHz spectrum band. This will ultimately enable the creation of a low-cost and energy-efficient 5G millimetre-wave network that could potentially trigger the development of ultra-reliable low latency communications, which is critical for emerging intelligent transportation systems and will maintain Australia’s leadership position in the development of break-through wireless technology.Read moreRead less
Low-Cost Wireless Transmitter with Compact Package for Industrial Sensing . This project aims to provide a solid foundation for silicon-based transmitter design with beam-steering capability operating beyond 100 GHz. The project expects to advance knowledge in low-cost radio-frequency integrated circuit design with miniaturised packaging technology for use in industrial sensing. Expected outcomes of this project include a prototype consisting of a miniaturised 140-GHz phased-array transmitter wi ....Low-Cost Wireless Transmitter with Compact Package for Industrial Sensing . This project aims to provide a solid foundation for silicon-based transmitter design with beam-steering capability operating beyond 100 GHz. The project expects to advance knowledge in low-cost radio-frequency integrated circuit design with miniaturised packaging technology for use in industrial sensing. Expected outcomes of this project include a prototype consisting of a miniaturised 140-GHz phased-array transmitter with packaged antenna arrays, along with a developed selection guideline to choose the "best" silicon-based technology node for cost-effective design. This should provide benefits for organisations working on wireless sensing technologies and lead to new ways of using these technologies for a variety of emerging applications.Read moreRead less
Data-driven monitoring of raceway dynamics in ironmaking blast furnaces. Raceway dynamics in ironmaking blast furnaces affect operational stability and cost considerably, yet their dynamic behaviour has not been well monitored online. The project aims to develop a data-driven model for monitoring the internal state of gas-solid-powder reacting flow in the raceway and predicting raceway anomalies online. It will be achieved by combining particle-fluid numerical simulations with data processing an ....Data-driven monitoring of raceway dynamics in ironmaking blast furnaces. Raceway dynamics in ironmaking blast furnaces affect operational stability and cost considerably, yet their dynamic behaviour has not been well monitored online. The project aims to develop a data-driven model for monitoring the internal state of gas-solid-powder reacting flow in the raceway and predicting raceway anomalies online. It will be achieved by combining particle-fluid numerical simulations with data processing and reduced-order state observer, supported by lab/plant experiments, and collaborating with two industry partners from coal and steel industries. The project outcomes including codes, models and raceway control strategies can help promote Australian metallurgical coal's global markets and ultimately the Australian economy.Read moreRead less
Innovation in Australian mid-market firms: The critical role of leader cognition. The innovation literature has focused on innovation in large corporations and small entrepreneurial firms, ignoring medium-sized firms. With a rare opportunity to work with a partner organisation on a range of mid-market firms, the project aims to focus on the unique theoretical aspects of innovation in medium-sized firms. The project’s investigation addresses critical gaps in the innovation strategy literature and ....Innovation in Australian mid-market firms: The critical role of leader cognition. The innovation literature has focused on innovation in large corporations and small entrepreneurial firms, ignoring medium-sized firms. With a rare opportunity to work with a partner organisation on a range of mid-market firms, the project aims to focus on the unique theoretical aspects of innovation in medium-sized firms. The project’s investigation addresses critical gaps in the innovation strategy literature and contributes to a nascent literature on the microfoundations of organisational outcomes. Specifically, the project focuses on how leader cognitions drive the intensity and type of innovation and influence the performance consequences of innovation. The project also aims to provide practical prescriptions to medium-sized firms in Australia.Read moreRead less