Engineering improved technology for nanoparticle-based adjuvant manufacture. Over the next decade nanotechnology will redefine vaccines for animal and human health. Nanoparticle adjuvants will boost engineered vaccines that use minimal antigens such as recombinant proteins and synthetic peptides. This project aims to develop a platform technology for making and controlling the properties of inulin nanoparticles by optimising the engineering and manufacturing aspects of inulin nanoparticles to fu ....Engineering improved technology for nanoparticle-based adjuvant manufacture. Over the next decade nanotechnology will redefine vaccines for animal and human health. Nanoparticle adjuvants will boost engineered vaccines that use minimal antigens such as recombinant proteins and synthetic peptides. This project aims to develop a platform technology for making and controlling the properties of inulin nanoparticles by optimising the engineering and manufacturing aspects of inulin nanoparticles to fundamentally understand the relationship between physical-chemical properties and efficacy. Completion of this project aims to produce potent nanoparticle-based adjuvants underpinned by novel manufacturing technology, to ultimately facilitate the development of more effective and protective vaccines for animals and humans.Read moreRead less
Nanoarchitectured multifunctional porous superparamagnetic nanoparticles. This project aims to develop a method for the direct detection of biomarkers based on a new class of highly porous superparamagnetic nanoparticles with peroxidase-like activity. The particles will be used as dispersible capture agents for isolating specific targets in biological samples, and electrocatalytic nanozymes for naked-eye evaluation and electrochemical detection. The project is expected to develop simple, low-cos ....Nanoarchitectured multifunctional porous superparamagnetic nanoparticles. This project aims to develop a method for the direct detection of biomarkers based on a new class of highly porous superparamagnetic nanoparticles with peroxidase-like activity. The particles will be used as dispersible capture agents for isolating specific targets in biological samples, and electrocatalytic nanozymes for naked-eye evaluation and electrochemical detection. The project is expected to develop simple, low-cost, portable devices for the analysis of exosomes and exosomal miRNA in biological samples. The future development of this technology into diagnostic devices will improve patient outcomes by enabling earlier disease diagnosis and improved monitoring of treatment.Read moreRead less
Single molecule sensing on nanopillars: Reading complex molecular circuits. This project aims to develop an entirely new nanotechnology to visualise dynamic molecular circuits in real time, and within any biological sample as small as a single cell. This project expects to generate new knowledge in the field of cell biology and sensor technology, using innovative nanofabrication and nanoscopic fluid flows to advance understanding of the emerging field of single protein molecule interactions in c ....Single molecule sensing on nanopillars: Reading complex molecular circuits. This project aims to develop an entirely new nanotechnology to visualise dynamic molecular circuits in real time, and within any biological sample as small as a single cell. This project expects to generate new knowledge in the field of cell biology and sensor technology, using innovative nanofabrication and nanoscopic fluid flows to advance understanding of the emerging field of single protein molecule interactions in cellular pathways. Expected outcomes include a universal technology platform to detect single molecules in single cells, with potential to deliver valuable intellectual property of commercial interest and economic benefit through technological advancements.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE170100174
Funder
Australian Research Council
Funding Amount
$193,000.00
Summary
Acoustic levitation facility for high pressure multiphase systems research. This project aims to create a specialised acoustic levitation facility that delivers precise control of a suspended particle/droplet/bubble within a high pressure continuous phase, and simultaneous measurement of multiple bulk and interfacial properties. Acoustic levitation enables container-less experiments, offering opportunities for applied engineering and fundamental science. This acoustic levitation system will be i ....Acoustic levitation facility for high pressure multiphase systems research. This project aims to create a specialised acoustic levitation facility that delivers precise control of a suspended particle/droplet/bubble within a high pressure continuous phase, and simultaneous measurement of multiple bulk and interfacial properties. Acoustic levitation enables container-less experiments, offering opportunities for applied engineering and fundamental science. This acoustic levitation system will be integrated with a specialised Raman imaging microscope to study crystallisation, mass transfer and molecular exchange, in application areas including energy transport, carbon capture and storage, and protein nucleation. This project is expected to open new avenues in engineering, chemistry and physics.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE210101666
Funder
Australian Research Council
Funding Amount
$395,588.00
Summary
Engineering nanoparticles with enhanced adhesion at the nano-bio interfaces. This project aims to develop a next-generation adhesive nanoparticle platform through in-depth understandings of nanoparticle interactions with bio-interfaces. This project expects to generate new knowledge in the multidisciplinary research field at nano-bio-interfaces by using a recently developed nano-colloidal probe technology, instructing the rational design of nanoparticles with enhanced interface adhesive properti ....Engineering nanoparticles with enhanced adhesion at the nano-bio interfaces. This project aims to develop a next-generation adhesive nanoparticle platform through in-depth understandings of nanoparticle interactions with bio-interfaces. This project expects to generate new knowledge in the multidisciplinary research field at nano-bio-interfaces by using a recently developed nano-colloidal probe technology, instructing the rational design of nanoparticles with enhanced interface adhesive properties. Expected outcomes include a family of adhesive nanoparticles designed for nanopesticide and animal feed applications, with the potential to deliver valuable intellectual property of commercial interest and economic benefit through technology advancement.Read moreRead less
A New Platform of Bio-inspired Nanoparticles for Enhanced Cellular Delivery. Delivery of various molecules into cells is crucial in modern medicine. Compared to viral vectors, non-viral vectors are safer delivery vehicles, but their delivery efficiency must be improved before they can be broadly used. Inspired by the surface topography of viruses with high infectivity, this project aims to provide a fundamental understanding of the impact of surface roughness on cellular delivery efficiency; and ....A New Platform of Bio-inspired Nanoparticles for Enhanced Cellular Delivery. Delivery of various molecules into cells is crucial in modern medicine. Compared to viral vectors, non-viral vectors are safer delivery vehicles, but their delivery efficiency must be improved before they can be broadly used. Inspired by the surface topography of viruses with high infectivity, this project aims to provide a fundamental understanding of the impact of surface roughness on cellular delivery efficiency; and to use this knowledge in the designed synthesis of a new family of bio-inspired non-viral nanoparticles with both safety and high cellular delivery efficiency. The new and high performance nano-carriers will become a platform technology with broad bio-applications in gene therapy, cancer therapy and bio-imaging.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE110100017
Funder
Australian Research Council
Funding Amount
$300,000.00
Summary
An integrated system for measuring thermoelectric properties of advanced materials. This facility will establish an integrated measuring system which will form the key step in developing thermoelectric materials. The instruments will support groundbreaking research in developing advanced materials with significant economic and environmental benefits for many industries, such as materials manufacturing and improving automobile energy efficiency.
Discovery Early Career Researcher Award - Grant ID: DE200100448
Funder
Australian Research Council
Funding Amount
$400,116.00
Summary
Developing high-performance GeTe-based thermoelectric materials. This project aims to develop high-performance germanium telluride-based thermoelectric materials by microstructure engineering and band engineering, which will accelerate the drive for eco-friendly energy technology. The outcomes can result in innovative strategies for maximising thermoelectric performance in broader materials and lead to significant progress in knowledge of materials science, solid-state physics, and chemical scie ....Developing high-performance GeTe-based thermoelectric materials. This project aims to develop high-performance germanium telluride-based thermoelectric materials by microstructure engineering and band engineering, which will accelerate the drive for eco-friendly energy technology. The outcomes can result in innovative strategies for maximising thermoelectric performance in broader materials and lead to significant progress in knowledge of materials science, solid-state physics, and chemical science. Thermoelectric devices assembled from as-obtained high-efficiency materials can be used for recovering waste-heat in mining industries and harvesting the waste-heat from engines to improve fuel consumption efficiency, which will strategically boost Australia's energy industry, environment, and economy.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE180101190
Funder
Australian Research Council
Funding Amount
$359,446.00
Summary
Interfacial nano-engineering of electrodes for perovskite solar cells. This project aims to explore new strategies of functional electrode design and interfacial engineering for efficient and stable perovskite solar cell application. The key concept is to modify the electron transport and perovskite layers through structural design, interfacial engineering and contact passivation, for use in high-performance solar-to-electricity conversion systems with improved light harvesting and charge collec ....Interfacial nano-engineering of electrodes for perovskite solar cells. This project aims to explore new strategies of functional electrode design and interfacial engineering for efficient and stable perovskite solar cell application. The key concept is to modify the electron transport and perovskite layers through structural design, interfacial engineering and contact passivation, for use in high-performance solar-to-electricity conversion systems with improved light harvesting and charge collection. Expected project outcomes will place Australia at the forefront of practical low-cost and large-scale solar energy conversion technologies.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE170100892
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
Designing compressible hybrid supercapacitors from graphene aerogels. This project aims to develop high-performance compressible energy storage devices. Compressible hybrid supercapacitors are promising energy storage devices for elastic and wearable electronics under large strain and deformation. However, the controlled fabrication of such devices is challenging. This project aims to design and synthesise compressible hybrid supercapacitors using graphene aerogels as substrates through structur ....Designing compressible hybrid supercapacitors from graphene aerogels. This project aims to develop high-performance compressible energy storage devices. Compressible hybrid supercapacitors are promising energy storage devices for elastic and wearable electronics under large strain and deformation. However, the controlled fabrication of such devices is challenging. This project aims to design and synthesise compressible hybrid supercapacitors using graphene aerogels as substrates through structural design and surface modification. The success of the project will benefit Australia’s booming graphite industry and promote Australian competitiveness in wearable electronics markets.Read moreRead less