Microwave System for Early Breast Cancer Detection Employing Ultra Wideband Conformal Array Antenna. Breast cancer is the most common cancer diagnosed in women in various parts of the world. Currently the primary method for breast screening is X-ray mammography and in rare cases Magnetic Resonance Imaging. X-ray mammography has saved many lives, but the technology still produces a relativity high number of false negative and false positive diagnoses. In the last decade, active microwave techniqu ....Microwave System for Early Breast Cancer Detection Employing Ultra Wideband Conformal Array Antenna. Breast cancer is the most common cancer diagnosed in women in various parts of the world. Currently the primary method for breast screening is X-ray mammography and in rare cases Magnetic Resonance Imaging. X-ray mammography has saved many lives, but the technology still produces a relativity high number of false negative and false positive diagnoses. In the last decade, active microwave techniques have attracted considerable interest as viable alternatives to X-ray mammography. This project aims at the design and development of a low-cost microwave system, which will complement all the currently available breast cancer diagnosis tools. Read moreRead less
Microwave System for Breast Cancer Detection. Breast cancer is the most common cancer diagnosed in women in various parts of the world. Currently the primary method for breast screening is X-ray mammography and in rare cases Magnetic Resonance Imaging. X-ray mammography has saved many lives, but the technology still produces a relativity high number of false negative and false positive diagnoses. In the last decade, active microwave techniques have attracted considerable interest as viable alter ....Microwave System for Breast Cancer Detection. Breast cancer is the most common cancer diagnosed in women in various parts of the world. Currently the primary method for breast screening is X-ray mammography and in rare cases Magnetic Resonance Imaging. X-ray mammography has saved many lives, but the technology still produces a relativity high number of false negative and false positive diagnoses. In the last decade, active microwave techniques have attracted considerable interest as viable alternatives to X-ray mammography. This project aims at the design and development of a low-cost microwave system, which will complement X-ray mammography as a breast cancer diagnosis tool. Read moreRead less
The Stemformatics gene expression compendium: development of multivariate statistical approaches for cross platform analyses. Scientific data is gathered in many different forms, but there are significant gaps in our ability to analyse multiple datasets when generated on different pieces of equipment. This project will study three typical research questions in stem cell biology to develop new analytical approaches to help solve this major data gap.
Genetic variation of single cell transcriptional heterogeneity in HiPSCs. This project aims to investigate whether induced pluripotent stem cells (iPSC) can be used to study the functions of genetic variants associated with human phenotypes and cell fate decisions. The project will utilise technology to produce single cell RNA sequence data for 100,000s of cells. By sequencing individual cells, the genetic control of cellular heterogeneity both within and between cells can be identified, and in ....Genetic variation of single cell transcriptional heterogeneity in HiPSCs. This project aims to investigate whether induced pluripotent stem cells (iPSC) can be used to study the functions of genetic variants associated with human phenotypes and cell fate decisions. The project will utilise technology to produce single cell RNA sequence data for 100,000s of cells. By sequencing individual cells, the genetic control of cellular heterogeneity both within and between cells can be identified, and in doing so, will provide significant benefit by revealing the potential for iPSC to be used for functional translation of human genomics.Read moreRead less
Plate Wave Tomography for Reconstruction of Laminar Defects. The proposed project promotes a conceptual advance in the application of plate waves for the quantitative reconstruction of laminar defects by investigating fundamental experimental and analytical aspects of a novel approach in plate wave ultrasonic tomography. A successful development will have a comparable significance in the area of health monitoring of thin structures as computer tomography had in medical imaging. Previous attempts ....Plate Wave Tomography for Reconstruction of Laminar Defects. The proposed project promotes a conceptual advance in the application of plate waves for the quantitative reconstruction of laminar defects by investigating fundamental experimental and analytical aspects of a novel approach in plate wave ultrasonic tomography. A successful development will have a comparable significance in the area of health monitoring of thin structures as computer tomography had in medical imaging. Previous attempts have ignored wave scattering effects, and therefore do not describe the correct physics of the problem. With its combined experimental-numerical approach, the proposed fundamental studies will help to identify the potential of plate wave ultrasonic tomography for in-situ health monitoring of realistic structures and smart materials design.Read moreRead less
Tomographic Imaging of Structural Damage in Plates. The potential benefit of structural health monitoring is highlighted by the socio-economic impact of structural failure, which may result in loss of lives, infrastructure disruptions and loss of productivity. This proposal promotes a fundamental advance in the novel concept of ultrasonic diffraction tomography for imaging early stage structural damage in plates. The successful development will represent an essential advance in quantitative non- ....Tomographic Imaging of Structural Damage in Plates. The potential benefit of structural health monitoring is highlighted by the socio-economic impact of structural failure, which may result in loss of lives, infrastructure disruptions and loss of productivity. This proposal promotes a fundamental advance in the novel concept of ultrasonic diffraction tomography for imaging early stage structural damage in plates. The successful development will represent an essential advance in quantitative non-destructive evaluation of thin structures and enable the transition of the technique to realistic structures with all the potential benefits in mechanical and civil infrastructure management resulting in improved safety, reduced maintenance costs and the use of more efficient structural designs.Read moreRead less
Signal transduction and the control of bacterial respiration by the NtrYX two component regulatory system. This proposal will define the structural and functional properties of the NtrYX two component signal transduction and define its role in the regulation of respiratory gene expression. The human pathogen Neisseria gonorrhoeae will be used as a model organism for a diverse range of 'oxidase positive' bacteria that possess NtrYX. The outcome will be a major contribution to the understanding of ....Signal transduction and the control of bacterial respiration by the NtrYX two component regulatory system. This proposal will define the structural and functional properties of the NtrYX two component signal transduction and define its role in the regulation of respiratory gene expression. The human pathogen Neisseria gonorrhoeae will be used as a model organism for a diverse range of 'oxidase positive' bacteria that possess NtrYX. The outcome will be a major contribution to the understanding of way in which respiratory gene expression is controlled in bacterial species for which Escherichia coli is not a suitable model. Read moreRead less
Photosynthetic traits as “key performance indicators” of coral health. The objective of this project is to advance knowledge on the healthy functioning of the coral–algal symbiosis, which defines the response of coral reef ecosystems to worldwide environmental change. Current approaches to address this problem have linked coral health to algal symbiont diversity but have been unable to resolve the fundamental symbiont functional traits that govern this link – the “key performance indicators (KPI ....Photosynthetic traits as “key performance indicators” of coral health. The objective of this project is to advance knowledge on the healthy functioning of the coral–algal symbiosis, which defines the response of coral reef ecosystems to worldwide environmental change. Current approaches to address this problem have linked coral health to algal symbiont diversity but have been unable to resolve the fundamental symbiont functional traits that govern this link – the “key performance indicators (KPIs)”. This project plans to couple advanced physiological and functional genomics techniques to transform our understanding of how algal symbiont metabolic KPIs regulate coral growth and stress susceptibility. This may provide new diagnostic capability for the assessment of coral health and may enable us to improve coral reef ecosystem management.Read moreRead less
Dynamic DNA structure states and memory formation. Activity-induced gene expression is central to neural plasticity, learning, and memory; however, the underlying mechanisms of these processes in the brain have yet to be fully resolved. The aim of this proposal is to obtain a deeper understanding of the functional relationship between genes and brain function. By elucidating the full repertoire of epigenetic mechanisms in the brain during learning and the formation of memory, it is hoped that t .... Dynamic DNA structure states and memory formation. Activity-induced gene expression is central to neural plasticity, learning, and memory; however, the underlying mechanisms of these processes in the brain have yet to be fully resolved. The aim of this proposal is to obtain a deeper understanding of the functional relationship between genes and brain function. By elucidating the full repertoire of epigenetic mechanisms in the brain during learning and the formation of memory, it is hoped that the true nature of brain adaptation across the lifespan will be revealed. Findings which may then provide new opportunities to strengthen, maintain and optimise cognitive function.Read moreRead less
Cell-type specific profiling of nascent RNA in the brain during learning. This project aims to understand cell-type specific, fast-acting, and dynamic patterns of RNA expression that arise during learning and contribute to the formation of memory. Activity-induced gene expression is central to neural plasticity, learning and memory. The project will apply a new approach, which tags RNA inside living cells. The findings will be broadly applicable and create new opportunities for understanding the ....Cell-type specific profiling of nascent RNA in the brain during learning. This project aims to understand cell-type specific, fast-acting, and dynamic patterns of RNA expression that arise during learning and contribute to the formation of memory. Activity-induced gene expression is central to neural plasticity, learning and memory. The project will apply a new approach, which tags RNA inside living cells. The findings will be broadly applicable and create new opportunities for understanding the true nature of brain adaptation.Read moreRead less