Improving the efficiency of CRISPR gene editing in cells. Human red blood cells are well-characterised and the globin gene locus is a model system for the study of gene regulation. Gene editing technologies and delivery tools are evolving rapidly and the globin gene locus is the perfect model for gene editing optimisation. This collaboration between UNSW Sydney and CSL aims to bring together our combined expertise and new technologies to develop an optimal platform for genetic modification in a ....Improving the efficiency of CRISPR gene editing in cells. Human red blood cells are well-characterised and the globin gene locus is a model system for the study of gene regulation. Gene editing technologies and delivery tools are evolving rapidly and the globin gene locus is the perfect model for gene editing optimisation. This collaboration between UNSW Sydney and CSL aims to bring together our combined expertise and new technologies to develop an optimal platform for genetic modification in a red blood cell line. Simultaneously, this project aims to generate fundamental insights into mechanisms of human gene regulation. The technological and biological outcomes of this project will be of benefit for future gene editing applications.Read moreRead less
Developing an integrated device for on-farm detection of sugarcane diseases. Pathogenic organisms cause yield losses of more than $150M pa to the Australian sugarcane industry and many millions more worldwide. Partnering with Sugar Research Australia, this project aims to develop a novel on-farm diagnostic device, comprising new nanotechnology and magnetism-induced microfluidics with naked eye observation and electrochemical detection. This device is expected to enable improved disease managemen ....Developing an integrated device for on-farm detection of sugarcane diseases. Pathogenic organisms cause yield losses of more than $150M pa to the Australian sugarcane industry and many millions more worldwide. Partnering with Sugar Research Australia, this project aims to develop a novel on-farm diagnostic device, comprising new nanotechnology and magnetism-induced microfluidics with naked eye observation and electrochemical detection. This device is expected to enable improved disease management strategies through the prediction of potential risks and rapid and effective actions to mitigate impending yield loss. In turn productivity and sustainability of Australia’s sugar industry will be enhanced. The new platform device has great potential for improved disease management in other crops in Australia and globally.Read moreRead less
Enabling Disability? Autonomous Technologies & CaLD persons with disability. Over 1 million disabled Australians are from culturally and linguistically diverse (CaLD) communities, the majority of whom are ineligible for disability and multicultural services. CaLD persons with disability significantly rely on digital information systems, devices and platforms to secure their economic, social and cultural inclusion. Evidence to date documents the continual exclusionary impact of artificial intelli ....Enabling Disability? Autonomous Technologies & CaLD persons with disability. Over 1 million disabled Australians are from culturally and linguistically diverse (CaLD) communities, the majority of whom are ineligible for disability and multicultural services. CaLD persons with disability significantly rely on digital information systems, devices and platforms to secure their economic, social and cultural inclusion. Evidence to date documents the continual exclusionary impact of artificial intelligence (AI) behind such technologies in addition to its inaccessibility to complex end-users. Yet, AI is now central to socio-economic well being and inclusion. In partnership with community and industry, this project will inform future AI developments and policy increasing its adaptability, accessibility and affordability.
Read moreRead less
Development of drought tolerant, high protein legume for arid Australia. The aim of this research is to demonstrate the molecular basis of a non-proteinogenic amino acid toxin accumulation by using genomics and genome editing to produce a non-transgenic, protein rich legume. The significance of the outcomes will be a fundamental understanding of how non-proteinogenic amino acids are metabolised in plants and an inexpensive, high-protein feed for the pork and chicken industries thereby reducing p ....Development of drought tolerant, high protein legume for arid Australia. The aim of this research is to demonstrate the molecular basis of a non-proteinogenic amino acid toxin accumulation by using genomics and genome editing to produce a non-transgenic, protein rich legume. The significance of the outcomes will be a fundamental understanding of how non-proteinogenic amino acids are metabolised in plants and an inexpensive, high-protein feed for the pork and chicken industries thereby reducing production costs and increasing profitability. The outcomes from the research are fundamental knowledge of non-proteinogenic amino acid metabolism and turnkey approach to identify, engineer, test and produce value added crops. The benefits of the research are a multi-purpose crop for Australian crop and animal producers.Read moreRead less
Low-Cost Multiple Pencil-Beam Lens Antenna System. The project aims to develop a new multiple pencil beam antenna system, taking advantage of CIs' preliminary inventions in lens antennas, 3D printed antennas and arrays, and antenna feeding networks. A dual-polarised antenna array architecture will enhance the sensing quality and resolution of our partner organisation's cleaning robot. It will enable the robot to recognise human presence and movement in low-light conditions for rapid and safe dis ....Low-Cost Multiple Pencil-Beam Lens Antenna System. The project aims to develop a new multiple pencil beam antenna system, taking advantage of CIs' preliminary inventions in lens antennas, 3D printed antennas and arrays, and antenna feeding networks. A dual-polarised antenna array architecture will enhance the sensing quality and resolution of our partner organisation's cleaning robot. It will enable the robot to recognise human presence and movement in low-light conditions for rapid and safe disinfection of public spaces. The project will have an immediate socio-economic impact on local businesses and communities. The outcomes of the project will create safer public environments for people living and working in Australia, and boost economic recovery in the post-pandemic period.Read moreRead less
Socially Responsible Insurance in the Age of Artificial Intelligence. This project aims to discover the social costs and benefits of using Artificial Intelligence in insurance, and to design practical interventions—responsible design workshops, practical guidance, regulatory proposals, new algorithmic tools—that realise the benefits while mitigating the costs. It expects to generate new knowledge drawing on philosophy, law and sociology, working closely with practitioners at the forefront of dep ....Socially Responsible Insurance in the Age of Artificial Intelligence. This project aims to discover the social costs and benefits of using Artificial Intelligence in insurance, and to design practical interventions—responsible design workshops, practical guidance, regulatory proposals, new algorithmic tools—that realise the benefits while mitigating the costs. It expects to generate new knowledge drawing on philosophy, law and sociology, working closely with practitioners at the forefront of deploying AI in insurance. Expected outcomes include novel ethical AI-based approaches to product design, pricing and claims administration. This should benefit insurers and consumers, realising efficiency gains made possible by AI, without unacceptable costs to privacy, fairness, and the unaccountable exercise of power. Read moreRead less
Advancing digital inclusion in low income Australian families. This ethnographic investigation explores the complex relationship between digital and social inclusion, and social infrastructure's role (education facilities, charities, government services) in supporting low-income families' social and economic participation. It gathers insights from families in six diverse communities from Far North Queensland to Tasmania, across diverse urban, regional and rural locations. It focuses on the digit ....Advancing digital inclusion in low income Australian families. This ethnographic investigation explores the complex relationship between digital and social inclusion, and social infrastructure's role (education facilities, charities, government services) in supporting low-income families' social and economic participation. It gathers insights from families in six diverse communities from Far North Queensland to Tasmania, across diverse urban, regional and rural locations. It focuses on the digital inclusion implications of children's home and school learning experiences, school leavers' transitions into work, and parenting in digital times. The project is a collaboration with Australia's leading digital inclusion organisations and will develop new practices, policies and sector wide solutions.Read moreRead less
Wideband Silicon-Based Radio-Frequency Front-End Module for 5G New Radio . The project aims to advance knowledge in radio-frequency integrated circuit design in low-cost silicon technologies, particularly power amplifiers design with enhanced energy efficiency at output power back-off levels. The intended outcome of this project will be a wideband RF front-end module with beam steering capability that can cover the 24-50 GHz spectrum band. This will ultimately enable the creation of a low-cost a ....Wideband Silicon-Based Radio-Frequency Front-End Module for 5G New Radio . The project aims to advance knowledge in radio-frequency integrated circuit design in low-cost silicon technologies, particularly power amplifiers design with enhanced energy efficiency at output power back-off levels. The intended outcome of this project will be a wideband RF front-end module with beam steering capability that can cover the 24-50 GHz spectrum band. This will ultimately enable the creation of a low-cost and energy-efficient 5G millimetre-wave network that could potentially trigger the development of ultra-reliable low latency communications, which is critical for emerging intelligent transportation systems and will maintain Australia’s leadership position in the development of break-through wireless technology.Read moreRead less
Low-Cost Wireless Transmitter with Compact Package for Industrial Sensing . This project aims to provide a solid foundation for silicon-based transmitter design with beam-steering capability operating beyond 100 GHz. The project expects to advance knowledge in low-cost radio-frequency integrated circuit design with miniaturised packaging technology for use in industrial sensing. Expected outcomes of this project include a prototype consisting of a miniaturised 140-GHz phased-array transmitter wi ....Low-Cost Wireless Transmitter with Compact Package for Industrial Sensing . This project aims to provide a solid foundation for silicon-based transmitter design with beam-steering capability operating beyond 100 GHz. The project expects to advance knowledge in low-cost radio-frequency integrated circuit design with miniaturised packaging technology for use in industrial sensing. Expected outcomes of this project include a prototype consisting of a miniaturised 140-GHz phased-array transmitter with packaged antenna arrays, along with a developed selection guideline to choose the "best" silicon-based technology node for cost-effective design. This should provide benefits for organisations working on wireless sensing technologies and lead to new ways of using these technologies for a variety of emerging applications.Read moreRead less
Data-driven monitoring of raceway dynamics in ironmaking blast furnaces. Raceway dynamics in ironmaking blast furnaces affect operational stability and cost considerably, yet their dynamic behaviour has not been well monitored online. The project aims to develop a data-driven model for monitoring the internal state of gas-solid-powder reacting flow in the raceway and predicting raceway anomalies online. It will be achieved by combining particle-fluid numerical simulations with data processing an ....Data-driven monitoring of raceway dynamics in ironmaking blast furnaces. Raceway dynamics in ironmaking blast furnaces affect operational stability and cost considerably, yet their dynamic behaviour has not been well monitored online. The project aims to develop a data-driven model for monitoring the internal state of gas-solid-powder reacting flow in the raceway and predicting raceway anomalies online. It will be achieved by combining particle-fluid numerical simulations with data processing and reduced-order state observer, supported by lab/plant experiments, and collaborating with two industry partners from coal and steel industries. The project outcomes including codes, models and raceway control strategies can help promote Australian metallurgical coal's global markets and ultimately the Australian economy.Read moreRead less