Improving the efficiency of CRISPR gene editing in cells. Human red blood cells are well-characterised and the globin gene locus is a model system for the study of gene regulation. Gene editing technologies and delivery tools are evolving rapidly and the globin gene locus is the perfect model for gene editing optimisation. This collaboration between UNSW Sydney and CSL aims to bring together our combined expertise and new technologies to develop an optimal platform for genetic modification in a ....Improving the efficiency of CRISPR gene editing in cells. Human red blood cells are well-characterised and the globin gene locus is a model system for the study of gene regulation. Gene editing technologies and delivery tools are evolving rapidly and the globin gene locus is the perfect model for gene editing optimisation. This collaboration between UNSW Sydney and CSL aims to bring together our combined expertise and new technologies to develop an optimal platform for genetic modification in a red blood cell line. Simultaneously, this project aims to generate fundamental insights into mechanisms of human gene regulation. The technological and biological outcomes of this project will be of benefit for future gene editing applications.Read moreRead less
Enhancing Australian Universities' Research Commercialisation Performance. The primary aims of the project are to develop a detailed understanding of the systematic barriers to research commercialisation within Australian universities and to promote innovation within the commercialisation through the adoption of effective processes. The project will also explore the needs of the smaller and regional universities to develop effective strategies that will enhance their research commercialisation c ....Enhancing Australian Universities' Research Commercialisation Performance. The primary aims of the project are to develop a detailed understanding of the systematic barriers to research commercialisation within Australian universities and to promote innovation within the commercialisation through the adoption of effective processes. The project will also explore the needs of the smaller and regional universities to develop effective strategies that will enhance their research commercialisation capacity and performance through the promotion of industry uptake of their research outcomes.Read moreRead less
Elastic and biodegradable sponges/aerogels from exfoliated silk nanofibres . The aim of this project is to investigate methods to produce highly porous elastic sponges from silk protein nanofibres. These sponges will have optimal mechanical, insulation and degradation properties making them suitable for a wide range of applications including the biomedical and personal care sectors, where current products have significant drawbacks due to the use of non-biodegradable synthetic materials. Outco ....Elastic and biodegradable sponges/aerogels from exfoliated silk nanofibres . The aim of this project is to investigate methods to produce highly porous elastic sponges from silk protein nanofibres. These sponges will have optimal mechanical, insulation and degradation properties making them suitable for a wide range of applications including the biomedical and personal care sectors, where current products have significant drawbacks due to the use of non-biodegradable synthetic materials. Outcomes include new knowledge on controlling porous structures and tailoring properties to targeted applications. This project, by laying the groundwork for a new generation of bio-based materials, will benefit the Australian advanced manufacturing sector, and enhance Australia's standing in materials science and engineering.Read moreRead less
Radio Frequency Wireless Monitoring in Sleep Apnoea (Particularly for Paediatric Patients). Disease diagnosis, chronic disease monitoring and stress monitoring all are limited by diagnostic systems that are attached to patients by wires restricting the recording of such parameters to limited intervals in the clinician's office. The proposed system will enable patients to have a range of physiological parameters recorded without the attachment of wires. This will enable extensive periods of dia ....Radio Frequency Wireless Monitoring in Sleep Apnoea (Particularly for Paediatric Patients). Disease diagnosis, chronic disease monitoring and stress monitoring all are limited by diagnostic systems that are attached to patients by wires restricting the recording of such parameters to limited intervals in the clinician's office. The proposed system will enable patients to have a range of physiological parameters recorded without the attachment of wires. This will enable extensive periods of diagnostic data to be recorded to characterize respiratory, cardiac and other parameters during extended periods, and during normal daily activity. In addition the system can be used to monitor patients with chronic disease and detect trends in their disease.Read moreRead less
Photonic Antenna: Nested multi-band patch antenna and arrayed photonic interconnect. This project aims to investigate the design of a broadband ?photonic antenna? for airborne radar warning and electronic countermeasure systems. The project will investigate the development of a suite of printed antennas that cover bands in the range from 2-40 GHz realised on a single substrate. Nesting these antennas to reduce system size, and integration of this module with a custom optical modulator array and ....Photonic Antenna: Nested multi-band patch antenna and arrayed photonic interconnect. This project aims to investigate the design of a broadband ?photonic antenna? for airborne radar warning and electronic countermeasure systems. The project will investigate the development of a suite of printed antennas that cover bands in the range from 2-40 GHz realised on a single substrate. Nesting these antennas to reduce system size, and integration of this module with a custom optical modulator array and RF signal combiner will be investigated. The resulting broadband antenna suite with photonic interconnect will require minimal fabrication and packaging resources, and will thus be an economically viable photonic solution for practical defence systems.Read moreRead less
Investigation into improved wireless communication for rural and regional Australia. The project will improve the performance of wireless communications allowing better and more accessible communication throughout rural and regional Australia. This will enable a more efficient communications as it will reduce the requirements of cables.
The Impact of Commercial Funding on Research Team Effectiveness in Health and Medical Research. The Health and Medical Research Sector has seen an increase in collaborations between public and private industry sectors. Consequently, research teams, essentially the functional units that carry out the research, may be funded from commercial and/or non-commercial sources. This project will investigate the impact of commercial funding on research teams. This ground breaking study will be of great va ....The Impact of Commercial Funding on Research Team Effectiveness in Health and Medical Research. The Health and Medical Research Sector has seen an increase in collaborations between public and private industry sectors. Consequently, research teams, essentially the functional units that carry out the research, may be funded from commercial and/or non-commercial sources. This project will investigate the impact of commercial funding on research teams. This ground breaking study will be of great value in the development of research commercialisation policies in Universities, Research Institutes, companies and Government. Its analysis of team effectiveness will assist to identify those characteristics that enhance the performance of research teams, which will have beneficial effects to those who work in them, and ultimately to those who depend on the results of their efforts.Read moreRead less
Understanding the Drafting-against-Untwisting Process for Engineering Fine and Soft Yarns of Low Hairiness. This research will lead to much improved understanding of a very novel yarn engineering process to achieve fine, soft and low-hairiness yarns from natural fibres. It will demonstrate that Australia not only provides quality wool and cotton fibres, but also leads the world in innovative textile engineering technologies that can enhance the competitive positions of its natural fibres in the ....Understanding the Drafting-against-Untwisting Process for Engineering Fine and Soft Yarns of Low Hairiness. This research will lead to much improved understanding of a very novel yarn engineering process to achieve fine, soft and low-hairiness yarns from natural fibres. It will demonstrate that Australia not only provides quality wool and cotton fibres, but also leads the world in innovative textile engineering technologies that can enhance the competitive positions of its natural fibres in the global fibre market. This research promotes value adding in Australian fibre products by developing advanced yarn engineering technology, which will be of significant national benefit to the multi-billion natural fibre industries in Australia.Read moreRead less
Control points in nitrogen uptake: enhancing the response of cereals to nitrogen supply and demand. Vast amounts of nitrogen fertiliser are applied to cereal crops to maintain yields. By uncovering what limits nitrogen uptake in cereals, this project will provide the scientific basis for improving nitrogen use efficiency and decreasing fertiliser use, with significant economic and environmental benefits.
Multimodal retinal imaging provides "insight" into cerebrovascular ageing. Multimodal retinal imaging provides "insight" into cerebrovascular ageing. This project aims to develop a multi-modal imaging technology platform to simultaneously measure amyloid beta and its neurovascular sequelae to identify novel early biomarkers of ageing in the eye and brain. The growing ageing population is an increasing socioeconomic burden. The central nervous system is particularly susceptible to ageing, which i ....Multimodal retinal imaging provides "insight" into cerebrovascular ageing. Multimodal retinal imaging provides "insight" into cerebrovascular ageing. This project aims to develop a multi-modal imaging technology platform to simultaneously measure amyloid beta and its neurovascular sequelae to identify novel early biomarkers of ageing in the eye and brain. The growing ageing population is an increasing socioeconomic burden. The central nervous system is particularly susceptible to ageing, which is difficult to measure at its onset. Critically, as the eye is an easily accessible extension of the cortex, retinal imaging may be a non-invasive surrogate to assess ageing changes in the brain. Anticipated outcomes are a sensitive detector of neural ageing, improved preventative measures, reducing the socioeconomic burden of ageing, and improved quality of life.Read moreRead less